Pleomorphic Adenoma: Report of Five Cases

Pleomorphic Adenoma (P A), the most common benign tumor of salivary gland, is common to occur in parotid gland and the submandibular gland. However, as far as minor salivary glands are concerned, the most common site is hard palate and very few cases are reported to occur in soft palate. In the present case report, one case found in soft palate, three cases involving hard palate and one case is found extra orally involving submandibular gland. All the cases were diagnosed on the basis of clinical features. CT Scan report (as in case I) and confirmed by histopathological report. The patient was given palliative radiotherapy due to poor cardiac condition of the patient. Other cases were treated with surgical excision. Follow up examination of all five cases was done for different durations. No re-occurrence was reported

Congenital Epulis : Report of Two Cases

Congenital epulis of the newborn is a rare tumor of infancy. It occurs more often in female that in males and in the maxilla more than in the mandible. Various theories of its origin have been described. Here two cases of congenital epulis are presented. Case one is an unusual case of congenital epulis involving alveolar mucosa of maxilla and mandible in a girl and case two is the single congenital epulis involving alveolar mucosa of mandible in a boy is reported

"A Clinical and Radiographic Study of Supernumerary Teeth": Report of Hundred Cases with Review of Literature

Supernumerary teeth are commonly encountered in our day to day life by the general dentist. Most supernumerary teeth are located in the maxilla with male predilection. Detection of supernumerary teeth is best achieved by thorough clinical and radiographic examination. Their management should form part of a comprehensive treatment plan. This article presents a clinical and radiographic study of hundred cases of supernumerary teeth and an overview of the clinical problems associated with supernumerary teeth

DOUBLE PALATE WITH TERATOM - A Case Report

Double palate is a unique, congen_it3i, extremely rare and infrequent occurrence in the oro-facial complex. Most of other congenital anomalies of palate are of frequent occurrence and have an early and easy diagnosis. The reported case was an extremely rare and unique with duplication of palate and of maxillary dental arch. The patient had normal mandibular dentition, broad flat-palate very unusual to the age, depressed-nasal bridge, anatomically incompetent but potentially competent lips, hypertelorism with no other skeletal deformity. The patient had already been operated for growth in the palatal region one year ago. The present case needs a multi-approach team management for the future rehabilitation of oro-facial complex

Fibrous Dysplasia of Jaws - Eight Case Reports with Review of Literature

The difficult problem of diagnosis in fibrous dysplasia is well recognised. A clear-cut diagnosis can seldom be made on the basis of clinical, radiological or histological examination alone. Although the usefulness of radiographic examination in the diagnosis of fibrous dysplasia of the skull and facial bones have been highlighted. Histologic and radiographic findings do not always correspond. The radiograph does, however, define the limits and characteristics of the condition grossly. Some of the radiographic features of this disease are sufficiently characteristic as to appear at tunes to be diagnostic

Oral manifestations in patients with gastro-esophageal reflux disease: A hospital-based case-control study

Aim: To analyze the occurrence and correlation of oral manifestations of patients affected by gastro-esophageal reflux disease (GERD), especially with dental erosion. Materials and Methods: With a simple randomization method, a total of 120 patients, GERD-diagnosed patients (group 1, n = 60), based on complaints and reviewed by gastroenterologists through proper history, clinical pictures, and established investigations, and healthy individuals (group 2, n = 60), were enrolled in the study. Oral manifestations such as xerostomia, oral acid/burning sensation, subjective halitosis, dental sensitivity, and dental erosion were evaluated in both groups. The Chi-square test and continuous variables were compared by the Mann–Whitney test and the Kruskal–Wallis test (P value < 0.05, significant). Results: The Mann–Whitney U test on the distribution of the gastric complaints between two groups revealed a significant difference in all the variables. A significant difference was found in the distribution of all the oral manifestations except halitosis and dentinal hypersensitivity between both groups. The Chi-square test between the heartburn and dental erosions revealed a significant association (c2 = 293.761, df = 1, P < 0.001), whereas there was no significant association between heartburn and dentinal hypersensitivity. Conclusion: GERD and dental erosions had no significant correlation, whereas other oral manifestations and mucosal changes were found significant with GERD

Bone Biomarkers and Subsequent Survival in Men with Hormone-sensitive Prostate Cancer: Results from the SWOG S1216 Phase 3 Trial of Androgen Deprivation Therapy with or Without Orteronel

BackgroundBone biomarkers are strongly prognostic for overall survival (OS) in men with castration-resistant prostate cancer but not fully established for hormone-sensitive prostate cancer (HSPC).ObjectiveBone biomarkers in HSPC were prospectively evaluated as part of a phase 3 study of androgen deprivation therapy&nbsp;±&nbsp;the CYP17 inhibitor orteronel.Design, setting, and participantsPatients were randomly divided into training (n&nbsp;=&nbsp;316) and validation (n&nbsp;=&nbsp;633) sets. Recursive partitioning and Cox proportional hazard models were employed.Outcome measurements and statistical analysisBone resorption (C-telopeptide and pyridinoline) and bone formation markers (C-terminal collagen propeptide and bone alkaline phosphatase) were assessed from patient sera.Results and limitationsOf 1279 men, 949 had evaluable baseline bone biomarkers. Optimal cutoffs were identified to define elevated levels of each of the four biomarkers (all p&nbsp;&lt;&nbsp;0.05) that were associated with worse OS. After adjusting for clinical risk factors in the validation set, elevated bone biomarkers were statistically significantly associated with an increased risk of death (hazard ratios ranging from 1.37 to 1.92). Recursive partitioning algorithms applied to the training set identified three risk groups (low, intermediate, and poor) with differential OS outcomes (median OS: 8.2, 5.1, and 2.1 yr, respectively) based on combinations of bone biomarkers. These results were confirmed in the validation set.ConclusionsIn men with HSPC initiating androgen deprivation therapy, bone biomarkers are strongly and independently prognostic for OS. Bone biomarker levels alone or in combination with clinical covariates identify unique subsets of men with differential OS outcomes. These results validate the clinical value of bone biomarker assessment in the HSPC state, extending bone biomarker utility beyond the castration-resistant state.Patient summaryIn men with newly diagnosed metastatic prostate cancer, high levels of bone turnover biomarkers are associated with a shorter lifespan