Just Serve Yourself...

Party meals may be as formal or informal as the hostess desires. The type of meal wished and the kind of party given will determine its method of serving. The informal service, however, is very popular because of the friendly atmosphere. The informal service is best put into use through serving the meal as a buffet luncheon or supper. This form of service is especially appropriate for a large number of guests or when the number of people to be served is more than can be accommodated by the dining room table

Lemon or Cream?...

The story is told that more than 250 years ago a dreamy-eyed Dutchman living in China made a discovery. He found that by adding a little hot water to a curious leaf, he had a most interesting drink. He went to England, taking the leaf with him, but the English would have nothing to do with him and his queer hot drink

Simple Table Service for the Home

We are living in a time of high pressure, and many things that help make life more livable are apt to be crowded out The dining table is the center of the social life of the home. Because of our high pressure living and the many different interests each member of the family has, the only time when all can be at home is at dinner

Luncheon, Shamrock-Trimmed...

In searching for the origin of St. Patrick\u27s Day we find that St. Patrick, patron saint of Ireland, was not Irish himself, as many suppose. In the book, Customs of Mankind, by Lilliam Eichler, we find that his birthplace is somewhat obscure. The French claim him, the Scotch and the Welsh claim him, but his true birthplace is not known

The Iowa Homemaker vol.11, no.4

Lemon or Cream?… By Ida M. Shilling His Majesty’s Room… By Anafred Stephenson Betty Gets a New Dress… By Margaret Bruechert What Shall I wear?…? By Margaret McDonoug

The Iowa Homemaker vol.11, no.9

If Mother Always Does It… By Lydia v. Swanson And So We Have Grapefruit By Louise L’Engle From Cleopatra to Betty Coed… By Ruth Ellen Lovrien Luncheon, Shamrock-Trimmed… By Ida M. Shillin

The Iowa Homemaker vol.11, no.8

House Not for Sale… By Joanne M. Hansen, page 1 Home Management Mothers… By Helen Bishop, page 2 “Tell Me a Poem”… By Lorraine Sandstrom, page 3 When the Box Was Opened… By Cora B. Miller, page 4 Just Serve Yourself… By Ida M. Shilling, page 4 Modernizing Marriage… By Ethel Cessna Morgan, page 5 Girls 4-H Clubs By Clara Austin, page 6 Alumnae Echoes… By Anafred Stephenson, page 8 Editorial, page 9 Inside Information By Helen Jewell and Betty Martin, page 1

The Iowa Homemaker vol.10, no.3

Iowa State “Mans” the Kitchen by Helen Melton, page 1 At Home in Nippon by Sarah Field, page 2 And Rush That Order, Please! by Bessie Hammer, page 3 Luncheon – Mile High by Mildred Ghrist Day, page 3 Gotta Job? by Julia Bourne, page 4 “P’s” and “Q’s” in China Selection by Ida M. Shilling, page 5 4-H Club by Helen Melton, page 6 State Association by Marcia E. Turner, page 8 Child Health May Day by Anafred Stephenson, page 10 Editorial, page 11 Alumnae News by Dorothy B. Anderson, page 1

Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

International audienceLithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li + PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li + PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi + Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li + PGS and lithium treatment responsedefined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li + PGS was positively associated with lithium treatment response in the ConLi + Gen cohort, in both the categorical (P = 9.8 × 10 −12 , R 2 = 1.9%) and continuous (P = 6.4 × 10 −9 , R 2 = 2.6%) outcomes. Compared to bipolar patients in the 1 st decile of the risk distribution, individuals in the 10 th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10 −4 , R 2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li + PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment