Flow chart for inclusion of study participants.

<p>Flow chart for inclusion of study participants.</p

Unadjusted and adjusted association analyses of child and adult adiposity predictors of LTL.

<p>AR is adiposity rebound; LTL is leukocyte telomere length. WHR is waist-to-hip ratio, BMI is body mass index, calculated as weight (kg)/height (m)². BAI is body adiposity index, calculated as (hip circumference (cm))/((height(m)^1.5)−18). BMI <i>z-score</i> change was calculated separately in males and females as the difference between the <i>z-scores</i> of BMI at AR, and BMI at 31 years. The number of individuals in each analysis is given (N); those in adjusted analyses are slightly lower than corresponding unadjusted analyses due to missing data for one or more covariates.</p>a<p>Linear regression model adjusted for maternal parity, SES at birth, Smoking at 31 years, SES at 31 years, children at 31 years and qPCR plate. In addition to these potential confounders, the model was also adjusted for age at menarche in women.</p>b<p>% change in LTL per unit change in predictor variable.</p>c<p>Statistically significant <i>P_corrected</i> values are shown in <b>bold</b>. FDR <i>P_corrected</i> values were calculated after adjustment using the Benjamini-Hochberg procedure <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099133#pone.0099133-Aviv2" target="_blank">[34]</a>, which provides a correction for multiple testing.</p

Characteristics of the NFBC1986 cohort.

<p>Data are given as MEAN (range) or as N (percentage).</p

Estimates of risk percentages for childhood obesity for given pairs of parental BMIs according to the NFBC1986 equation.

<p>Estimates are provided for three different combinations of birth weight, maternal professional category, number of household members and maternal gestational smoking, corresponding to three progressively higher risk backgrounds. Grey cells correspond to risk estimates within the highest risk quartile in the overall population.</p

Risk threshold and predictive properties corresponding to the 75° percentile of calculated risk for the obesity phenotypes in the NFBC1986.

<p>Risk threshold and predictive properties corresponding to the 75° percentile of calculated risk for the obesity phenotypes in the NFBC1986.</p

Stepwise multiple logistic models for prediction of obesity phenotypes: ORs and p values associated with predictors, AUROC and P of Hosmer-Lemeshow test in the final models (bold characters) and AUROCs and P of Hosmer-Lemeshow of each step (italic characters).

<p>Stepwise multiple logistic models for prediction of obesity phenotypes: ORs and p values associated with predictors, AUROC and P of Hosmer-Lemeshow test in the final models (bold characters) and AUROCs and P of Hosmer-Lemeshow of each step (italic characters).</p