Microstructural ordering of nanofibers in flow-directed assembly

Fabrication of highly ordered and dense nanofibers assemblies is of key importance for high-performance and multi-functional material and device applications. In this work, we design an experimental approach in silico, where shear flow and solvent evaporation are applied to tune the alignment, overlap of nanofibers, and density of the assemblies. Microscopic dynamics of the process is probed by dissipative particle dynamics simulations, where hydrodynamic and thermal fluctuation effects are fully modeled. We find that microstructural ordering of the assembled nanofibers can be established within a specific range of the Peclet numbers and evaporation rates, while the properties of nanofibers and their interaction are crucial for the local stacking order. The underlying mechanisms are elucidated by considering the competition between hydrodynamic coupling and thermal fluctuation. Based on these understandings, a practical design of flow channels for nanofiber assembly with promising mechanical performance is outlined.Accepted manuscriptSupporting documentatio

Foundations of offshore wind turbines: a review

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Tumor Tissue Detection using Blood-Oxygen-Level-Dependent Functional MRI based on Independent Component Analysis

Accurate delineation of gliomas from the surrounding normal brain areas helps maximize tumor resection and improves outcome. Blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) has been routinely adopted for presurgical mapping of the surrounding functional areas. For completely utilizing such imaging data, here we show the feasibility of using presurgical fMRI for tumor delineation. In particular, we introduce a novel method dedicated to tumor detection based on independent component analysis (ICA) of resting-state fMRI (rs-fMRI) with automatic tumor component identification. Multi-center rs-fMRI data of 32 glioma patients from three centers, plus the additional proof-of-concept data of 28 patients from the fourth center with non-brain musculoskeletal tumors, are fed into individual ICA with different total number of components (TNCs). The best-fitted tumor-related components derived from the optimized TNCs setting are automatically determined based on a new template-matching algorithm. The success rates are 100%, 100% and 93.75% for glioma tissue detection for the three centers, respectively, and 85.19% for musculoskeletal tumor detection. We propose that the high success rate could come from the previously overlooked ability of BOLD rs-fMRI in characterizing the abnormal vascularization, vasomotion and perfusion caused by tumors. Our findings suggest an additional usage of the rs-fMRI for comprehensive presurgical assessment

A Missense Mutation in PPARD Causes a Major QTL Effect on Ear Size in Pigs

Chinese Erhualian is the most prolific pig breed in the world. The breed exhibits exceptionally large and floppy ears. To identify genes underlying this typical feature, we previously performed a genome scan in a large scale White Duroc × Erhualian cross and mapped a major QTL for ear size to a 2-cM region on chromosome 7. We herein performed an identical-by-descent analysis that defined the QTL within a 750-kb region. Historically, the large-ear feature has been selected for the ancient sacrificial culture in Erhualian pigs. By using a selective sweep analysis, we then refined the critical region to a 630-kb interval containing 9 annotated genes. Four of the 9 genes are expressed in ear tissues of piglets. Of the 4 genes, PPARD stood out as the strongest candidate gene for its established role in skin homeostasis, cartilage development, and fat metabolism. No differential expression of PPARD was found in ear tissues at different growth stages between large-eared Erhualian and small-eared Duroc pigs. We further screened coding sequence variants in the PPARD gene and identified only one missense mutation (G32E) in a conserved functionally important domain. The protein-altering mutation showed perfect concordance (100%) with the QTL genotypes of all 19 founder animals segregating in the White Duroc × Erhualian cross and occurred at high frequencies exclusively in Chinese large-eared breeds. Moreover, the mutation is of functional significance; it mediates down-regulation of β-catenin and its target gene expression that is crucial for fat deposition in skin. Furthermore, the mutation was significantly associated with ear size across the experimental cross and diverse outbred populations. A worldwide survey of haplotype diversity revealed that the mutation event is of Chinese origin, likely after domestication. Taken together, we provide evidence that PPARD G32E is the variation underlying this major QTL

Comprehensive Control Method of Gas in Upper Corner of High Strength Fully Mechanized Coal Mine

Based on the problem of large gas emission and serious gas accumulation in upper corner of the intensive fully mechanized caving face, taking the fully mechanized caving face of Wangjialing Coal Mine in Hedong Mine as the research object, the main gas emission sources of the extremely intensive mining face with low permeability and low gas content were studied. The methods of gas extraction by inserting (burying) pipe in upper corner and directional drilling in upper corner were adopted and carried out. The application of engineering practice and comparative test of effect are carried out. The results show that the maximum extraction purity is 2.8 m³/min, the maximum gas concentration is 0.8% in upper corner, 3.11 m³/min in the high directional borehole and 0.71% in upper corner. After combined extraction, the total extraction purity is 1.33~7.93 m³/min and the fluctuation range of gas concentration in upper corner is reduced to 0.31~0.61% safe point. The effect of gas prevention and control in working face is remarkable

The Detection Method of Fire Abnormal Based on Directional Drilling in Complex Conditions of Mine

In the light of more and more urgent hidden fire abnormal detection problem in complex conditions of mine, a method which is used directional drilling technology is put forward. The method can avoid the obstacles in mine, and complete the fire abnormal detection. This paper based on analyzing the trajectory control of directional drilling, measurement while drilling and the characteristic of open branch process, the project of the directional drilling is formulated combination with a complex condition mine, and the detection of fire abnormal is implemented. This method can provide technical support for fire prevention, which also can provide a new way for fire anomaly detection in the similar mine

Chemical and Biological Properties of Quinochalcone C-Glycosides from the Florets of Carthamus tinctorius

Quinochalcone C-glycosides are regarded as characteristic components that have only been isolated from the florets of Carthamus tinctorius. Recently, quinochalcone C-glycosides were found to have multiple pharmacological activities, which has attracted the attention of many researchers to explore these compounds. This review aims to summarize quinochalcone C-glycosides’ physicochemical properties, chromatographic behavior, spectroscopic characteristics, as well as their biological activities, which will be helpful for further study and development of quinochalcone C-glycosides

Characteristics of Fracturing Fluid Invasion Layer and Its Influence on Gas Production of Shale Gas Reservoirs

With the increase of shale gas resource exploitation in our country during recent decades, the situations of low gas production, fast production decline rate, and low flowback rate have been appearing in field production. It is an urgent problem to be solved in shale gas production and it is therefore necessary to study the interaction of the shale gas reservoir and the detained fracturing fluid. In this paper, the Longmaxi Formation shale samples of Sichuan Basin were selected for a water invasion experiment. The fracture propagation law, the water invasion front location, and the water invasion thickness of deep and shallow shale reservoirs after water invasion were compared and analyzed by CT scanning technology. Based on the analysis of the experimental mechanism, a numerical simulation model was established. The dimensionless permeability and thickness of the fracturing fluid invasion layer were introduced to analyze the positive and negative effects of fracturing fluid retention on the reservoir. The results show that during the hydraulic fracturing of shale gas wells, fracturing fluid can quickly enter the complex fracture network, and then slowly enter the shale matrix under various mechanisms to form the fracturing fluid invasion layer. Compared with shallow shale reservoirs, deep shale reservoirs have lower porosity and permeability, which propagates microfractures in the matrix induced by fracturing fluid retention, and results in a smaller fracturing fluid invasion layer thickness. Both the negative effect of fracturing fluid retention on shale damage and the positive effect of microfracture formation and propagation exist simultaneously. The higher the dimensionless fracturing fluid invasion layer permeability, the more complex the fracture network formed in the fractured reservoir will be, resulting in a longer stable production period and a better development effect. When the dimensionless fracturing fluid invasion layer permeability is greater than 1, that is, when the positive effect of fracturing fluid retention is greater, and the thicker the dimensionless fracturing fluid invasion layer is, the better the development effect will be. Combining reservoir characteristics and fracture development, the key to obtaining high productivity of a shale gas well is to optimize the soaking time and the speed of flowback in order to extend the stable production period. In this paper, the characteristics of the fracturing fluid invasion layer and the influence of fracturing fluid retention on gas well productivity are deeply studied, which provides a certain theoretical basis for the optimization of shale gas extraction technology and the improvement of the gas–water two-phase productivity prediction method for fractured horizontal wells