Knowledge Nomads: Understanding an Overlooked Segment of the Workforce Helps Managers Lead

Managers have formal and official supervisory authority within an organizational hierarchy. As a result, a perennial concern of managers is employee mobility, i.e., the turnover of workers, and the implication of worker mobility for the staffing of critical functions in the organization

Titrating and Evaluating Multiple Drug Regimens within Subjects

The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the trial. This may lead to problems with patient enrollment and adherence to the study protocol, and even with early stopping rules, the time patients spend on inferior treatments may have lasting detrimental effects. This paper describes an evolutionary operation (EVOP) direct-search procedure to titrate combination doses within individual patients. The Nelder-Mead simplex direct-search method is used to titrate a combination of drugs within individual subjects. Desirability functions are incorporated to define the main response of interest and additional responses or constraints. Statistical methodology for determining whether the titrated treatment combination has resulted in an improvement in patient response and for evaluating whether a therapeutic synergism exists is developed. Inferences can be made about the efficacy of the combination or about the individual drugs that comprise the combination. This approach allows every patient the potential to benefit from the combination under study and permits the consideration of multiple endpoints simultaneously

Toxotes microlepis

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (p. 113-115).The maneuvering of fish is not only of interest to those wishing to better understand how fish function, but also is a great inspiration for designing underwater vehicles. This thesis provides the first characterization of the behavior of Toxotes microlepis, the archer fish, as it jumps for bait above the water surface. Two separate studies provide information on both the kinematics and hydrodynamics associated with the jump. The kinematic study makes use of high speed backlight videos and image processing, while the hydrodynamic study relies on high speed digital particle image velocimetry (DPIV). The kinematic study is able to successfully break the jumping behavior into three parts: (1) hovering, (2) thrust production and (3) gliding. Hovering is when the fish is beneath the surface of the water and is trying to maintain position. Thrust production occurs when the archer begins to perform tail strokes and exit the water, resulting in a sharp spike in acceleration and a subsequent increase in velocity. Gliding happens after the archer has partially left the water and is no longer flapping its tail, at which point the archer refrains from any motions until after it has captured its bait. Detailed velocity and acceleration plots are presented. The number of times an archer flaps its tail is shown to increase with the height of the bait, as is the maximum velocity it attains. Additionally, an energy balance is explored. For the hydrodynamic study, PIV shows that each time the archer fish performs a tail stroke during the thrust production phase, a jet is formed that provides impulse to enable jumping. Additionally, the anal fin is shown to have a significant impact on the thrust production, as it also produces a jet. Numerical results for the circulation and impulse created by these jets are presented.by Anna Margaret Shih.S.M

Bright light therapy to promote sleep in mothers of low-birth-weight infants: a pilot study

Having a low-birth-weight (LBW) infant in a neonatal intensive care unit (NICU) can intensify a mother’s sleep disturbances due to both stress and the dim lighting in the ICU setting, which desynchronizes circadian rhythms. The purpose of this pilot study was to examine the effectiveness of a 3-week bright light therapy intervention on sleep and health outcomes of mothers with LBW infants in the NICU. Controlled stratified randomization was used to assign 30 mothers to a treatment or control group. Data were collected at pretreatment (second week postpartum) and after the 3-week intervention. Sleep data were assessed by wrist actigraph (total sleep time [TST], circadian activity rhythms [CARs]) and the General Sleep Disturbance scale. Other outcome variables were measured by the Lee’s Fatigue scale, Edinburgh Postpartum Depression scale, and the Medical Outcomes Short Form 36, version 2. Mothers averaged 26.6 (SD = 6.3) years of age, and the majority were Black (73%). The mean gestational age for the infants was 27.7 (SD = 2.0) weeks. Small to large effect sizes were found when comparing the pre- to posttreatment differences between groups. Although none of the differences were statistically significant in this small sample, for mothers in the treatment group nocturnal TST (d = .33), CAR (d = 1.06), morning fatigue (d = .22), depressive symptoms (d = .40), physical health–related quality of life (d = .33), and mental health–related quality of life (d = .60) all improved compared to the control group. Bright light therapy is feasible for mothers with infants in an NICU. Clinically significant improvements have been evidenced; a larger-scale trial of effectiveness is needed

The Hispanic Paradox: Race/Ethnicity and Nativity, Immigrant Enclave Residence and Cognitive Impairment Among Older US Adults

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137472/1/jgs14806.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137472/2/jgs14806_am.pd

Relationships Between Urinary Metals and Diabetes Traits among Mexican americans in Starr County, Texas, Usa

Hispanics/Latinos have higher rates of type 2 diabetes (T2D), and the origins of these disparities are poorly understood. Environmental endocrine-disrupting chemicals (EDCs), including some metals and metalloids, are implicated as diabetes risk factors. Data indicate that Hispanics/Latinos may be disproportionately exposed to EDCs, yet they remain understudied with respect to environmental exposures and diabetes. The objective of this study is to determine how metal exposures contribute to T2D progression by evaluating the associations between 8 urinary metals and measures of glycemic status in 414 normoglycemic or prediabetic adults living in Starr County, Texas, a Hispanic/Latino community with high rates of diabetes and diabetes-associated mortality. We used multivariable linear regression to quantify the differences in homeostatic model assessments for pancreatic β-cell function, insulin resistance, and insulin sensitivity (HOMA-β, HOMA-IR, HOMA-S, respectively), plasma insulin, plasma glucose, and hemoglobin A1c (HbA1c) associated with increasing urinary metal concentrations. Quantile-based g-computation was utilized to assess mixture effects. After multivariable adjustment, urinary arsenic and molybdenum were associated with lower HOMA-β, HOMA-IR, and plasma insulin levels and higher HOMA-S. Additionally, higher urinary copper levels were associated with a reduced HOMA-β. Lastly, a higher concentration of the 8 metal mixtures was associated with lower HOMA-β, HOMA-IR, and plasma insulin levels as well as higher HOMA-S. Our data indicate that arsenic, molybdenum, copper, and this metal mixture are associated with alterations in measures of glucose homeostasis among non-diabetics in Starr County. This study is one of the first to comprehensively evaluate associations of urinary metals with glycemic measures in a high-risk Mexican American population

A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders

Acknowledgements The authors acknowledge support from their associated institutions which included: (i) the Intramural Research Program, National Institute on Aging, NIH, USA, (ii) the Karolinska Institutet, Sweden, (iii) Aevisbio Inc., USA, (iv) Aevis Bio Inc., Republic of Korea, (v) G. d’Annunzio University of Chieti and Pescara, Italy, and (vi) University of Aberdeen, Scotland, UK. Funding The generation of this article was supported by: (i) the Intramural Research Program, National Institute on Aging, NIH: AG000994. (ii) The Technology Development Program of MSS, Republic of Korea (S2782046). (iii) The National Research Foundation (NRF) grant funded by the Republic of Korea Government (2021M3A9G2015889).Peer reviewedPublisher PD