2 research outputs found
Correlation of serum sclerostin and bone volume (BV/TV) among sham, Nx+PTx 0.6% and Nx+PTx 1.2% groups.
<p>Nx+PTx: 5/6 nephrectomy and total parathyroidectomy.</p
Preparation of Cationic Nanogels for Nucleic Acid Delivery
Cationic nanogels with site-selected functionality were
designed
for the delivery of nucleic acid payloads targeting numerous therapeutic
applications. Functional cationic nanogels containing quaternized
2-(dimethylamino)ethyl methacrylate and a cross-linker with reducible
disulfide moieties (qNG) were prepared by activators generated by
electron transfer (AGET) atom transfer radical polymerization (ATRP)
in an inverse miniemulsion. Polyplex formation between the qNG and
nucleic acid exemplified by plasmid DNA (pDNA) and short interfering
RNA (siRNA duplexes) were evaluated. The delivery of polyplexes was
optimized for the delivery of pDNA and siRNA to the Drosophila Schneider 2 (S2) cell-line. The qNG/nucleic
acid (i.e., siRNA and pDNA) polyplexes were found to be highly effective
in their capabilities to deliver their respective payloads