Evaluation of Bone Toxicity in Various Bones of Aged Rats

The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m2 body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 weeks by intravenous injection, and the femur, sternum, humerus and tibia were examined histopathologically. In the doxorubicin-treated group, thinning of the growth plate was remarkably observed in the proximal tibia and humerus; however, these changes were not observed in other regions. In addition, the osteoclast number per bone perimeter in the proximal tibia was significantly higher than others in control aged rat. Thus, recognizing the various histological reactions related to the time of epiphyseal closure is important for evaluating bone toxicity in aged rats

A Realistic Approach to Double-Entry Bookkeeping: Sganzini\u27s Interpretation of Accounts with Special Reference to the Transactions

The purpose of this paper is to explain the real nature of double-entry bookkeeping. And then this study is based on Sganzini\u27s theory of accounts called realistic theory. His starting point is the transactions of typical economic unit, e. g., a busines

Die materialistische Auffassung der doppelten Buchhaltung: Eine Erklarung des Wesens der Doppik aufgrund von Schar\u27schen "Reinvermogenstheorie"

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KINETIC PROPERTY OF A PRESSURE VESSEL MADE FROM CFRP FABRICATED A FILAMENT WINDING METHOD

Since the specific strength and the specific elasticity of carbon fiber reinforced plastics (CFRPs) are the greatest in practical materials, they are used abundantly in transport structures. This CFRP can also be used for a pressure vessel which stores liquid hydrazine, the required burst pressure is approximately 22MPa. Many researchers have been studying pressure vessels made from a CFRP fabricated by a filament winding (FW) method. In order to acquire the fundamental mechanical properties of a CFRP container, the small cylinder made from CFRP fabricated by the spiral winding type FW method is designed and manufactured. The winding angle of a carbon fiber of this cylinder is ±45 degrees. The plastic deformation of this cylinder generates from the strain range of 0.7%. So as to confirm by the analytical method that a small tank made from CFRP fabricated by the FW method can be utilized as a tank for liquid hydrazine, an analysis model is created. Since the pressure to which the strain of this CFRP tank reaches to 0.7% is approximately 35MPa, this small tank can be used as a fuel tank for micro satellites

Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding

AbstractThe type 1 sigma receptor expressed in Xenopus oocytes showed binding abilities for the sigma-1 ligands, [3H](+)pentazocine and [3H]NE-100, with similar kinetic properties as observed in native tissue membranes. Amino acid substitutions (Ser99Ala, Tyr103Phe and di-Leu105,106di-Ala) in the transmembrane domain did not alter the expression levels of the type 1 sigma receptor as determined by immunoblot analysis using an anti-type 1 sigma receptor antiserum. By contrast, ligand binding was significantly suppressed by the substitutions. These findings provide evidence that the transmembrane domain of the type 1 sigma receptor plays a critical role in ligand binding of this receptor