Morphologic change of Yoshida sarcoma cells and coelothelioma cells after exposing to the cell toxin from X-ray-irradiated animal

The unsaturated fatty acid fraction extracted from the liver of rabbit irradiated with X-rays exerts a strong cytotoxic effect on human coelothelioma cells and Yoshida sarcoma cells both in vitro and in vivo. The cell damage seems to initiate at the nucleus, finally leading to the complete cytolysis. The inhibiting effect of this substance on the mitosis of Yoshida sarcoma cells can be observed, especially marked from prophase up to metaphase giving almost the same results obtained after X-ray irradiation. From these results and the observations reported by several authors on the cell damage by X-ray irradiation, weshould call special attention to the fact that the essential mechanism of X-ray irradiation can be attributed to the cell toxin produced after the irradiation.</p

Experimental Studies on the Nature of Radiation Disturbances Part 1. Influence of X-ray Irradiation on the Histochemical Changes in Blood Cells

There are many studies on radiation disturbances but as for the causative factor of the disturbances it is vaguely considered to be the disorders of the hematopoietic organs and still it is uncertain whether such disturbances are due to the primary or the secondary factor, However, in our experiments we have come across the evidence indicating that such disorders can be induced even by an indirect causative factor. Following upon this point, we have studied the problem from histochemical standpoint of blood cells and have clarified that various substances what may be called toxic granules are produced during X-ray irradiation. Therefore, with the purpose to find an aid in the diagnosis of radiation disturbances as well as a clue in the elucidation of the causative factor we performed the present experiment by pursuing the relationship between the radition disturbance and the dosage of X-rays

A comparative study of flat surface design and medial pivot design in posterior cruciate-retaining total knee arthroplasty: a matched pair cohort study of two years

Abstract Background Component design is one of the contributory factors affecting the postoperative flexion angle. The purpose of this study was to compare short-term outcomes of flat surface and medial pivot designs in posterior cruciate-retaining (CR) total knee arthroplasty (TKA). Methods A retrospective, case-control, and observational cohort study consisted of matched-pairs of the flat surface design (Hi-Tech Knee II) and the medial pivot design (FINE Knee) in CR-TKA with a two-year follow-up period. Results Hi-Tech Knee II and FINE knee groups each included 7 males and 38 females. Surgical time was significantly shorter in the FINE Knee group than in the Hi-Tech Knee II group (104.8 min versus 154.9 min, p = 0.001). Estimated total blood loss was significantly lower in the FINE Knee group than in the Hi-Tech Knee II group (654 ml versus 1158 ml, p = 0.001). The postoperative flexion angle was significantly better in the FINE Knee group than in the Hi-Tech Knee II group (119.3 degrees versus 112.5 degrees), and was positively correlated with the preoperative flexion angle. Postoperative Knee Society scores were significantly better in the FINE Knee group than in the Hi-Tech Knee II group (93.0 points versus 85.0 points, p = 0.001), especially for postoperative pain relief (46.0 points versus 39.0 points out of 50, p = 0.001). Complications were not observed in either group over a two-year follow-up period. Conclusion The short-term outcome of the medial pivot design used in CR-TKA was more favorable than the flat surface design, especially for surgical time, estimated total blood loss, postoperative flexion angle, and knee pain

Additional file 1: of A comparative study of flat surface design and medial pivot design in posterior cruciate-retaining total knee arthroplasty: a matched pair cohort study of two years

Comprehensive data table of patient characteristics in the Hi-Tech Knee II and FINE Knee groups. (XLSX 31 kb