New Era, New Opportunity, Is GES DISC Ready for Big Data Challenge?

The new era of Big Data has opened doors for many new opportunities, as well as new challenges, for both Earth science research/application and data communities. As one of the twelve NASA data centers - Goddard Earth Sciences Data and Information Services Center (GES DISC), one of our great challenges has been how to help research/application community efficiently (quickly and properly) accessing, visualizing and analyzing the massive and diverse data in natural hazard research, management, or even prediction. GES DISC has archived over 2000 TB data on premises and distributed over 23,000 TB of data since 2010. Our data has been widely used in every phase of natural hazard management and research, i.e. long term risk assessment and reduction, forecasting and predicting, monitoring and detection, early warning, damage assessment and response. The big data challenge is not just about data storage, but also about data discoverability and accessibility, and even more, about data migration/mirroring in the cloud. This paper is going to demonstrate GES DISCs efforts and approaches of evolving our overall Web services and powerful Giovanni (Geospatial Interactive Online Visualization ANd aNalysis Infrastructure) tool into further improving data discoverability and accessibility. Prototype works will also be presented

Developing Data Services to Provide Data Quality Information for Global Satellite-Based Precipitation Products

Global satellite-based precipitation products have been widely used in research and applications around the world. Compared to ground-based observations, satellite-based measurements provide data on a global scale, especially in remote continents and over oceans. The NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC) is home to NASA global precipitation product archives including the Tropical Rainfall Measuring Mission (TRMM), the Global Precipitation Measurement (GPM), as well as other global and regional precipitation products. Precipitation is one of the top downloaded and accessed parameters in the GES DISC data archive. Meanwhile, users want to easily locate and obtain data quality information at regional and global scales to better understand how precipitation products perform and how reliable they are. As a data service provider, it is necessary to provide easy access to data quality information. However, such information normally is not available, and when it is available, it is not in one place and difficult to locate. In this presentation, we will present such challenges and activities at the GES DISC to address precipitation data (other datasets as well) quality issues

Psychological Sequelae of the Station Nightclub Fire: Comparing Survivors with and without Physical Injuries Using a Mixed-Methods Analysis

Background: Surveying survivors from a large fire provides an opportunity to explore the impact of emotional trauma on psychological outcomes. Methods: This is a cross-sectional survey of survivors of The Station Fire. Primary outcomes were post-traumatic stress (Impact of Event Scale – Revised) and depressive (Beck Depression Inventory) symptoms. Linear regression was used to examine differences in symptom profiles between those with and without physical injuries. The free-response section of the survey was analyzed qualitatively to compare psychological sequelae of survivors with and without physical injuries. Results: 104 participants completed the study survey; 47% experienced a burn injury. There was a 42% to 72% response rate range. The mean age of respondents was 32 years, 62% were male, and 47% experienced a physical injury. No significant relationships were found between physical injury and depressive or post-traumatic stress symptom profiles. In the qualitative analysis, the emotional trauma that survivors experienced was a major, common theme regardless of physical injury. Survivors without physical injuries were more likely to experience survivor guilt, helplessness, self-blame, and bitterness. Despite the post-fire challenges described, most survivors wrote about themes of recovery and renewal. Conclusions: All survivors of this large fire experienced significant psychological sequelae. These findings reinforce the importance of mental health care for all survivors and suggest a need to understand factors influencing positive outcomes

Robustness and Generalization

We derive generalization bounds for learning algorithms based on their robustness: the property that if a testing sample is "similar" to a training sample, then the testing error is close to the training error. This provides a novel approach, different from the complexity or stability arguments, to study generalization of learning algorithms. We further show that a weak notion of robustness is both sufficient and necessary for generalizability, which implies that robustness is a fundamental property for learning algorithms to work

Convective Systems over the South China Sea: Cloud-Resolving Model Simulations

The two-dimensional version of the Goddard Cumulus Ensemble (GCE) model is used to simulate two South China Sea Monsoon Experiment (SCSMEX) convective periods [18–26 May (prior to and during the monsoon onset) and 2–11 June (after the onset of the monsoon) 1998]. Observed large-scale advective tendencies for potential temperature, water vapor mixing ratio, and horizontal momentum are used as the main forcing in governing the GCE model in a semiprognostic manner. The June SCSMEX case has stronger forcing in both temperature and water vapor, stronger low-level vertical shear of the horizontal wind, and larger convective available potential energy (CAPE). The temporal variation of the model-simulated rainfall, time- and domain-averaged heating, and moisture budgets compares well to those diagnostically determined from soundings. However, the model results have a higher temporal variability. The model underestimates the rainfall by 17 % to 20 % compared to that based on soundings. The GCE model-simulated rainfall for June is in very good agreement with the Tropical Rainfall Measuring Mission (TRMM), precipitation radar (PR), and the Global Precipitation Climatology Project (GPCP). Overall, the model agrees better with observations for the June case rather than the May case. The model-simulated energy budgets indicate that the two largest terms for both cases are net condensatio

Improving Global Precipitation Product Access at the GES DISC

The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) has been actively and continually engaged in improving the access to and use of Global Precipitation Measurement (GPM), Tropical Precipitation Measuring Mission (TRMM), and other precipitation data, including the following new services and Ongoing development activities: Updates on GPM products and data services, New features in Giovanni, Ongoing development activities; and Precipitation product and service outreach activities

Improving Global Precipitation Product Access at the GES DISC

The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) has been actively and continually engaged in improving the access to and use of Global Precipitation Measurement (GPM), Tropical Precipitation Measuring Mission (TRMM), and other precipitation data, including the following new services and ongoing development activities: Updates on GPM products and data services; New features in Giovanni; Ongoing development activities; Precipitation product and service outreach activities

ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage

Recent clinical findings support the notion that the progressive deterioration of cholesterol homeostasis is a central player in Alzheimer's disease (AD). Epidemiological studies suggest that high midlife plasma total cholesterol levels are associated with an increased risk of AD. This paper reports the plasma cholesterol concentrations, cognitive performance, locomotor activity and neuropathological signs in a murine model (transgenic mice expressing apoB100 but knockout for the LDL receptor [LDLR]) of human familial hypercholesterolaemia (FH). From birth, these animals have markedly elevated LDL-cholesterol and apolipoprotein B100 (apoB100) levels. These transgenic mice were confirmed to have higher plasma cholesterol concentrations than wild-type mice, an effect potentiated by aging. Further, 3-month-old transgenic mice showed cholesterol (total and fractions) concentrations considerably higher than those of 18-month-old wild-type mice. The hypercholesterolaemia of the transgenic mice was associated with a clear locomotor deficit (as determined by rotarod, grip strength and open field testing) and impairment of the episodic-like memory (determined by the integrated memory test). This decline in locomotor activity and cognitive status was associated with neuritic dystrophy and/or the disorganization of the neuronal microtubule network, plus an increase in astrogliosis and lipid peroxidation in the brain regions associated with AD, such as the motor and lateral entorhinal cortex, the amygdaloid basal nucleus, and the hippocampus. Aortic atherosclerotic lesions were positively correlated with age, although potentiated by the transgenic genotype, while cerebral β-amyloidosis was positively correlated with genetic background rather than with age. These findings confirm hypercholesterolaemia as a key biomarker for monitoring mild cognitive impairment, and shows these transgenic mice can be used as a model for cognitive and psycho-motor decline

Calcium phosphates and silicon: exploring methods of incorporation

Background: Bioinorganics have been explored as additives to ceramic bone graft substitutes with the aim to improve their performance in repair and regeneration of large bone defects. Silicon (Si), an essential trace element involved in the processes related to bone formation and remodeling, was shown not only to enhance osteoblasts proliferation but also to stimulate the differentiation of mesenchymal stem cells (MSCs) and preosteoblasts into the osteogenic lineage. In this study, the added value of Si to calcium phosphate (CaP) coatings was evaluated. Methods: Tissue culture plastic well plates were coated with a thin CaP layer to which traces amounts of Si were added, either by adsorption or by incorporation through coprecipitation. The physicochemical and structural properties of the coatings were characterized and the dissolution behavior was evaluated. The adsorption/incorporation of Si was successfully achieved and incorporated ions were released from the CaP coatings. Human MSCs were cultured on the coatings to examine the effects of Si on cell proliferation and osteogenic differentiation. For the statistical analysis, a one-way ANOVA with Bonferroni post-hoc test was performed. Results: The results showed that human MSCs (hMSCs) responded to the presence of Si in the CaP coatings, in a dosedependent manner. An increase in the expression of markers of osteogenic differentiation by human MSCs was observed as a result of the increase in Si concentration. Conclusions: The incorporation/adsorption of Si into CaP coatings was successfully achieved and hMSCs responded with an increase in osteogenic genes expression with the increase of Si concentration. Furthermore, hMSCs cultured on CaP-I coatings expressed higher levels of ALP and OP, indicating that this may be the preferred method of incorporation of bioinorganics into CaPsPortuguese Foundation for Science and Technology (FCT) for providing Ana I. Rodrigues her PhD scholarship (Grant No. SFRH/BD/69962/2010). This work was partially supported by national funds through the FCT under the scope of the project OSTEOSYNTHESIS project (PTDC/CTM-BIO/0814/2012) and by the European Regional Development Fund (FEDER) through the “COMPETE” - Operational Programme for Competitiveness factors (FCOMP-01-0124-FEDER-028491).info:eu-repo/semantics/publishedVersio

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer's disease (AD) brain. Here we further characterize the mechanism of NPD1's neurogenic actions using 3xTg-AD mouse models and human neuronal-glial (HNG) cells in primary culture, either challenged with Aβ42 oligomeric peptide, or transfected with beta amyloid precursor protein (βAPP)sw (Swedish double mutation APP695sw, K595N-M596L). We also show that NPD1 downregulates Aβ42-triggered expression of the pro-inflammatory enzyme cyclooxygenase-2 (COX-2) and of B-94 (a TNF-α-inducible pro-inflammatory element) and apoptosis in HNG cells. Moreover, NPD1 suppresses Aβ42 peptide shedding by down-regulating β-secretase-1 (BACE1) while activating the α-secretase ADAM10 and up-regulating sAPPα, thus shifting the cleavage of βAPP holoenzyme from an amyloidogenic into the non-amyloidogenic pathway. Use of the thiazolidinedione peroxisome proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone, the irreversible PPARγ antagonist GW9662, and overexpressing PPARγ suggests that the NPD1-mediated down-regulation of BACE1 and Aβ42 peptide release is PPARγ-dependent. In conclusion, NPD1 bioactivity potently down regulates inflammatory signaling, amyloidogenic APP cleavage and apoptosis, underscoring the potential of this lipid mediator to rescue human brain cells in early stages of neurodegenerations