One- and Two-Dimensional Analysis of Earth Dams

Earth dams may experience reduction in shear strength due to seismically induced pore pressures. Such reduction may be large enough to result in large deformations and eventual loss of the reservoir. While the analysis of embankment dams subject to earthquake loading is a complicated process, it is required for evaluation of seismic stability. In particular, the possibility of liquefaction in older, hydraulically-filled or otherwise poorly compacted dams during earthquakes presents a threat that must be addressed. This paper compares two methods of calculating the peak dynamic shear stress (critical to liquefaction evaluation) that occurs in an embankment during an earthquake. The first method is a one-dimensional analysis, which is simple, rapid and inexpensive. The second method is a two-dimensional finite element analysis, which is complicated, long and expensive. Because it is more desirable to use the simpler one-dimensional analysis, the results from the two analyses were compared and indicated that for slopes up to 35° the stresses were comparable

Fermion confinement induced by geometry

We consider a five-dimensional model in which fermions are confined in a hypersurface due to an interaction with a purely geometric field. Inspired by the Rubakov-Shaposhnikov field-theoretical model, in which massless fermions can be localized in a domain wall through the interaction of a scalar field, we show that particle confinement may also take place if we endow the five-dimensional bulk with a Weyl integrable geometric structure, or if we assume the existence of a torsion field acting in the bulk. In this picture, the kind of interaction considered in the Rubakov-Shaposhnikov model is replaced by the interaction of fermions with a geometric field, namely a Weyl scalar field or a torsion field. We show that in both cases the confinement is independent of the energy and the mass of the fermionic particle. We generalize these results to the case in which the bulk is an arbitrary n-dimensional curved space.Comment: 8 page

Cartan's spiral staircase in physics and, in particular, in the gauge theory of dislocations

In 1922, Cartan introduced in differential geometry, besides the Riemannian curvature, the new concept of torsion. He visualized a homogeneous and isotropic distribution of torsion in three dimensions (3d) by the "helical staircase", which he constructed by starting from a 3d Euclidean space and by defining a new connection via helical motions. We describe this geometric procedure in detail and define the corresponding connection and the torsion. The interdisciplinary nature of this subject is already evident from Cartan's discussion, since he argued - but never proved - that the helical staircase should correspond to a continuum with constant pressure and constant internal torque. We discuss where in physics the helical staircase is realized: (i) In the continuum mechanics of Cosserat media, (ii) in (fairly speculative) 3d theories of gravity, namely a) in 3d Einstein-Cartan gravity - this is Cartan's case of constant pressure and constant intrinsic torque - and b) in 3d Poincare gauge theory with the Mielke-Baekler Lagrangian, and, eventually, (iii) in the gauge field theory of dislocations of Lazar et al., as we prove for the first time by arranging a suitable distribution of screw dislocations. Our main emphasis is on the discussion of dislocation field theory.Comment: 31 pages, 8 figure

Improving Global Precipitation Product Access at the GES DISC

The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) has been actively and continually engaged in improving the access to and use of Global Precipitation Measurement (GPM), Tropical Precipitation Measuring Mission (TRMM), and other precipitation data, including the following new services and Ongoing development activities: Updates on GPM products and data services, New features in Giovanni, Ongoing development activities; and Precipitation product and service outreach activities

Improving Global Precipitation Product Access at the GES DISC

The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) has been actively and continually engaged in improving the access to and use of Global Precipitation Measurement (GPM), Tropical Precipitation Measuring Mission (TRMM), and other precipitation data, including the following new services and ongoing development activities: Updates on GPM products and data services; New features in Giovanni; Ongoing development activities; Precipitation product and service outreach activities

The Relative Contribution of High-Gamma Linguistic Processing Stages of Word Production, and Motor Imagery of Articulation in Class Separability of Covert Speech Tasks in EEG Data

Word production begins with high-Gamma automatic linguistic processing functions followed by speech motor planning and articulation. Phonetic properties are processed in both linguistic and motor stages of word production. Four phonetically dissimilar phonemic structures “BA”, “FO”, “LE”, and “RY” were chosen as covert speech tasks. Ten neurologically healthy volunteers with the age range of 21–33 participated in this experiment. Participants were asked to covertly speak a phonemic structure when they heard an auditory cue. EEG was recorded with 64 electrodes at 2048 samples/s. Initially, one-second trials were used, which contained linguistic and motor imagery activities. The four-class true positive rate was calculated. In the next stage, 312 ms trials were used to exclude covert articulation from analysis. By eliminating the covert articulation stage, the four-class grand average classification accuracy dropped from 96.4% to 94.5%. The most valuable features emerge after Auditory cue recognition (~100 ms post onset), and within the 70–128 Hz frequency range. The most significant identified brain regions were the Prefrontal Cortex (linked to stimulus driven executive control), Wernicke’s area (linked to Phonological code retrieval), the right IFG, and Broca’s area (linked to syllabification). Alpha and Beta band oscillations associated with motor imagery do not contain enough information to fully reflect the complexity of speech movements. Over 90% of the most class-dependent features were in the 30-128 Hz range, even during the covert articulation stage. As a result, compared to linguistic functions, the contribution of motor imagery of articulation in class separability of covert speech tasks from EEG data is negligible

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer's disease (AD) brain. Here we further characterize the mechanism of NPD1's neurogenic actions using 3xTg-AD mouse models and human neuronal-glial (HNG) cells in primary culture, either challenged with Aβ42 oligomeric peptide, or transfected with beta amyloid precursor protein (βAPP)sw (Swedish double mutation APP695sw, K595N-M596L). We also show that NPD1 downregulates Aβ42-triggered expression of the pro-inflammatory enzyme cyclooxygenase-2 (COX-2) and of B-94 (a TNF-α-inducible pro-inflammatory element) and apoptosis in HNG cells. Moreover, NPD1 suppresses Aβ42 peptide shedding by down-regulating β-secretase-1 (BACE1) while activating the α-secretase ADAM10 and up-regulating sAPPα, thus shifting the cleavage of βAPP holoenzyme from an amyloidogenic into the non-amyloidogenic pathway. Use of the thiazolidinedione peroxisome proliferator-activated receptor gamma (PPARγ) agonist rosiglitazone, the irreversible PPARγ antagonist GW9662, and overexpressing PPARγ suggests that the NPD1-mediated down-regulation of BACE1 and Aβ42 peptide release is PPARγ-dependent. In conclusion, NPD1 bioactivity potently down regulates inflammatory signaling, amyloidogenic APP cleavage and apoptosis, underscoring the potential of this lipid mediator to rescue human brain cells in early stages of neurodegenerations

ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage

Recent clinical findings support the notion that the progressive deterioration of cholesterol homeostasis is a central player in Alzheimer's disease (AD). Epidemiological studies suggest that high midlife plasma total cholesterol levels are associated with an increased risk of AD. This paper reports the plasma cholesterol concentrations, cognitive performance, locomotor activity and neuropathological signs in a murine model (transgenic mice expressing apoB100 but knockout for the LDL receptor [LDLR]) of human familial hypercholesterolaemia (FH). From birth, these animals have markedly elevated LDL-cholesterol and apolipoprotein B100 (apoB100) levels. These transgenic mice were confirmed to have higher plasma cholesterol concentrations than wild-type mice, an effect potentiated by aging. Further, 3-month-old transgenic mice showed cholesterol (total and fractions) concentrations considerably higher than those of 18-month-old wild-type mice. The hypercholesterolaemia of the transgenic mice was associated with a clear locomotor deficit (as determined by rotarod, grip strength and open field testing) and impairment of the episodic-like memory (determined by the integrated memory test). This decline in locomotor activity and cognitive status was associated with neuritic dystrophy and/or the disorganization of the neuronal microtubule network, plus an increase in astrogliosis and lipid peroxidation in the brain regions associated with AD, such as the motor and lateral entorhinal cortex, the amygdaloid basal nucleus, and the hippocampus. Aortic atherosclerotic lesions were positively correlated with age, although potentiated by the transgenic genotype, while cerebral β-amyloidosis was positively correlated with genetic background rather than with age. These findings confirm hypercholesterolaemia as a key biomarker for monitoring mild cognitive impairment, and shows these transgenic mice can be used as a model for cognitive and psycho-motor decline

GPM, TRMM, and Other Global Precipitation Products and Services at NASA GES DISC

Precipitation is a key environmental variable. For example, in agriculture, precipitation, temperature, water (soil moisture), solar radiation, NDVI, etc., are key variables.Rainfed agriculture major farming practices that rely on rainfall for water.Rainfed agriculture: >95% of farmed land (sub-Saharan Africa); 90% (Latin America); 75% (Near East and North Africa); 65% (East Asia); 60% (South Asia).Droughts and floods can cause severe crop loss. The Goddard Earth Sciences (GES) Data and Information Services Center (DISC), one of 12 NASA data centers, is located in Greenbelt, Maryland, USA. The NASA GES DISC is a major data archive center for global precipitation, water & energy cycles, atmospheric composition, and climate variability