The Current Situation, Problems and Countermeasures of High-Quality Economic and Social Development of Securities Companies Serving Districts and Counties

Districts and counties are the most basic units of administrative divisions in China. Therefore, the key to promoting high-quality economic and social development in China lies in promoting high-quality economic and social development in districts and counties. With the deepening of the “One Division One County” twinning assistance initiative, the role of securities companies in serving the high-quality economic and social development of districts and counties has become increasingly apparent. In order to better promote the high-quality economic and social development of securities companies serving districts and counties, this paper summarizes the main problems based on the analysis of the current situation of the high-quality economic and social development of securities companies serving districts and counties, and puts forward corresponding policy suggestions from the aspects of giving full play to the role of associations, building bridges serving districts and counties, giving full play to the professional advantages of securities companies, and creating characteristic comprehensive financial services

Free Energy of Anisotropic Strangeon Stars

Can pulsar-like compact objects release further huge free energy besides the kinematic energy of rotation? This is actually relevant to the equation of states of cold supra-nuclear matter, which is still under hot debate. Enormous energy is surely needed to understand various observations, such as $\gamma-$ray bursts, fast radio bursts and soft $\gamma-$ray repeaters. The elastic/gravitational-free energy of solid strangeon star is revisited, with two approaches to calculate in general relativity. It is found that huge free energy (> $10^{46}$ erg) could be released via starquakes, given an extremely small anisotropy ($(p_{\rm t}-p_{\rm r})/p_{\rm r} \sim 10^{-4}$, with $p_{\rm t}$/$p_{\rm r}$ the tangential/radial pressures)

Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation

SummaryThe lack of understanding of the interplay between hematopoietic stem cells (HSCs) and the immune system has severely hampered the stem cell research and practice of transplantation. Major problems for allogeneic transplantation include low levels of donor engraftment and high risks of graft-versus-host disease (GVHD). Transplantation of purified allogeneic HSCs diminishes the risk of GVHD but results in decreased engraftment. Here we show that ex vivo expanded mouse HSCs efficiently overcame the major histocompatibility complex barrier and repopulated allogeneic-recipient mice. An 8-day expansion culture led to a 40-fold increase of the allograft ability of HSCs. Both increased numbers of HSCs and culture-induced elevation of expression of the immune inhibitor CD274 (B7-H1 or PD-L1) on the surface of HSCs contributed to the enhancement. Our study indicates the great potential of utilizing ex vivo expanded HSCs for allogeneic transplantation and suggests that the immune privilege of HSCs can be modulated