Formulation and Application of Quantum Monte Carlo Method to Fractional Quantum Hall Systems

Quantum Monte Carlo method is applied to fractional quantum Hall systems. The use of the linear programming method enables us to avoid the negative-sign problem in the Quantum Monte Carlo calculations. The formulation of this method and the technique for avoiding the sign problem are described. Some numerical results on static physical quantities are also reported.Comment: Proceedings of The 15th International Conference on Electronic Properties of Two-Dimensional Systems (EP2DS-15

Effective Epilepsy Surgery for Post-Traumatic West Syndrome Following Abusive Head Trauma

West syndrome, an infantile developmental and epileptic encephalopathy with a deleterious impact on long-term development, requires early treatment to minimize developmental abnormality; in such cases, epilepsy surgery should be considered a powerful therapeutic option. We describe a 10-month-old female admitted with West syndrome associated with a hemispheric lesion following abusive head trauma. Her seizures were suppressed by hemispherotomy at 12 months of age, leading to developmental improvement. Surgical treatment of West syndrome following traumatic brain injury has not been reported previously but is worth considering as a treatment option, depending on patient age and brain plasticity

Discrepancy in tidal deformability of GW170817 between the Advanced LIGO twin detectors

We find that the Hanford and Livingston detectors of Advanced LIGO derive a distinct posterior probability distribution of binary tidal deformability tilde{Lambda} of the first binary-neutron-star merger GW170817. By analyzing public data of GW170817 with a nested-sampling engine and the default TaylorF2 waveform provided by the LALInference package, the probability distribution of the binary tidal deformability derived by the LIGO-Virgo detector network turns out to be determined dominantly by the Hanford detector. Specifically, by imposing the flat prior on tidal deformability of individual stars, symmetric 90% credible intervals of tilde{Lambda} are estimated to be 527^{+619}_{-345} with the Hanford detector, 927^{+522}_{-619} with the Livingston detector, and 455^{+668}_{-281} with the LIGO-Virgo detector network. Furthermore, the distribution derived by the Livingston detector changes irregularly when we vary the maximum frequency of the data used in the analysis. This feature is not observed for the Hanford detector. While they are all consistent, the discrepancy and irregular behavior suggest that an in-depth study of noise properties might improve our understanding of GW170817 and future events.Comment: 7 pages, 3 figures, matched to the published versio

Alteration of intestinal flora by the intake of enzymatic degradation products of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with improvement of skin condition

AbstractAdlay has been used as a traditional Chinese medicine and nutrient for its beneficial effects on bowel movements and skin care. This study examined the effect of enzymatic degradation product of adlay, “Super Hatomugi” (SPH) on human skin and the intestinal flora in a randomized, double-blind placebo-controlled study. The subjects were divided into three groups: 500mg SPH, 1000mg SPH, and placebo, taken daily for 4weeks. Hematological and skin condition examinations as well as an analysis of intestinal flora were performed 2weeks before and 10weeks after the start of the SPH intake. Skin condition was improved by SPH intake as revealed by a reduction in the number of nucleated epidermal cells. In addition, an increase in the fecal population of Bacteroidetes followed the SPH intake. These results show the possibility that SPH improves the skin condition and changes the proportions of intestinal flora

Unexpected Instability of Family of Repeats (FR), the Critical cis-Acting Sequence Required for EBV Latent Infection, in EBV-BAC Systems

A group of repetitive sequences, known as the Family of Repeats (FR), is a critical cis-acting sequence required for EBV latent infection. The FR sequences are heterogeneous among EBV strains, and they are sometimes subject to partial deletion when subcloned in E. coli-based cloning vectors. However, the FR stability in EBV-BAC (bacterial artificial chromosome) system has never been investigated. We found that the full length FR of the Akata strain EBV was not stably maintained in a BAC vector. By contrast, newly obtained BAC clones of the B95-8 strain of EBV stably maintained the full length FR during recombinant virus production and B-cell transformation. Investigation of primary DNA sequences of Akata–derived EBV-BAC clones indicates that the FR instability is most likely due to a putative secondary structure of the FR region. We conclude that the FR instability in EBV-BAC clones can be a pitfall in E. coli-mediated EBV genetics

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

Proteolysis-targeting chimaeras (PROTACs) as well as molecular glues such as immunomodulatory drugs (IMiDs) and indisulam are drugs that induce interactions between substrate proteins and an E3 ubiquitin ligases for targeted protein degradation. Here, we develop a workflow based on proximity-dependent biotinylation by AirID to identify drug-induced neo-substrates of the E3 ligase cereblon (CRBN). Using AirID-CRBN, we detect IMiD-dependent biotinylation of CRBN neo-substrates in vitro and identify biotinylated peptides of well-known neo-substrates by mass spectrometry with high specificity and selectivity. Additional analyses reveal ZMYM2 and ZMYM2-FGFR1 fusion protein—responsible for the 8p11 syndrome involved in acute myeloid leukaemia—as CRBN neo-substrates. Furthermore, AirID-DCAF15 and AirID-CRBN biotinylate neo-substrates targeted by indisulam and PROTACs, respectively, suggesting that this approach has the potential to serve as a general strategy for characterizing drug-inducible protein–protein interactions in cells

Determinations of light spectrums under sea ice with fiber optics spectrometer

A fiber optics spectrophotometer (USB2000, OceanOptics, USA) was applied to measure light conditions under sea ice at Saroma-ko Lagoon, Hokkaido Japan, in February and March 2005. One end of a 10 m quartz fiber optics (QP200-2-UV-VIS, OceanOptics, USA) fixed under sea ice led light to the other end, and the spectrophotometer determined the spectrum of the light at the other end on the sea ice. Signals from the spectrophotometer were normalized with the calibration light source (DH2000CAL, OceanOptics, USA) and a program (OOIBase, OOIIrad, OceanOptics, USA) and were determined as irradiance (w m^ mn^). Without the cosine-collector for collecting the light from 180 degrees in front, the fiber optics collected light from a narrow range and showed quite different spectrums from those determined with the cosine-collector. Spectrums with a peak at 570 nm were determined with the cosine-collector and corresponded well with the spectrums often determined at near coastal areas. Photon flux densities (μmol photons s^m^ nm^) were estimated from spectrums determined with the cosine-collector and correlated well (R^2=0.98) with those determined with the quantum sensor (LI-193, LI-COR, USA). These results showed that fiber optics spectrophotometer could determine the light conditions under sea ice both qualitatively and quantitatively

Significance of High-frequency Electrical Brain Activity

　Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding

A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification

Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case