Car-following method based on inverse reinforcement learning for autonomous vehicle decision-making

There are still some problems need to be solved though there are a lot of achievements in the fields of automatic driving. One of those problems is the difficulty of designing a car-following decision-making system for complex traffic conditions. In recent years, reinforcement learning shows the potential in solving sequential decision optimization problems. In this article, we establish the reward function R of each driver data based on the inverse reinforcement learning algorithm, and r visualization is carried out, and then driving characteristics and following strategies are analyzed. At last, we show the efficiency of the proposed method by simulation in a highway environment

AKR1C1 overexpression attenuates the inhibitory effect of glycyrrhizic acid on gastric cancer cell proliferation and migration

Purpose: To investigate the involvement of aldo-keto reductase family 1 member C1 (AKR1C1) in glycyrrhizic acid-mediated gastric cancer.Methods: Immunohistochemistry, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and western blot were used to assess AKR1C1 expression in gastric cancer. Cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and colony formation assay. Apoptosis was evaluated by flow cytometry. Transwell and wound healing assays were performed to investigate cell invasion and migration, respectively.Results: AKR1C1 was significantly upregulated in gastric cancer tissues and cells (p < 0.01). AKR1C1 knockdown suppressed cell proliferation, migration, and invasion of gastric cancer, but promoted cell apoptosis. Glycyrrhizic acid treatment reduced AKR1C1 expression in gastric cancer cells (p < 0.05). AKR1C1 overexpression attenuated the glycyrrhizic acid-induced increase in gastric cancer cell apoptosis as well as the decrease in cell proliferation, migration, and invasion.Conclusion: AKR1C1 contributes to gastric cancer cell proliferation and metastasis and counteracts the suppressive effects of glycyrrhizic acid on gastric cancer cell proliferation and metastasis

[μ-4-Benzoyl-1-(1-oxido-2-naphthyl­carbon­yl)thio­semicarbazidato(4−)]bis­[pyridine­copper(II)]

In the title dinuclear complex, [Cu2(C19H11N3O3S)(C5H5N)2], the two CuII centers have different coordination environments, viz. N2OS and N2O2, each exhibiting a distorted square-planar geometry. π–π inter­actions between the aromatic rings of neighbouring complexes [centroid–centroid distance = 3.856 (5) Å] link pairs of mol­ecules into centrosymmetric dimers, which are further packed into stacks along the b axis with relatively short Cu⋯Cu separations of 3.482 (1) Å. Weak inter­molecular C—H⋯N hydrogen bonds help to consolidate the crystal packing