338 research outputs found
A Note on Transverse Axial Vector and Vector Anomalies in U(1) Gauge Theories
The transverse axial vector and vector anomalies in four-dimensional U(1)
gauge theories studied in [10] is reexamined by means of perturbative methods.
The absence of transverse anomalies for both axial vector and vector current is
verified. We also show that the Pauli-Villars regularization and dimensional
regularization give the same result on the transverse anomaly of both axial
vector and vector current.Comment: Revtex4, 8 pages, two figures. Largely revised, using the
Pauli-Villars regularization instead of dimensional regularization in the
main proof. Final form to be published in Physics Letters
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Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by ligation of the left ascending artery and evaluated the effect of IL-22 on post-MI cardiac function and ventricular remodeling. Results: Daily subcutaneous injection of 100 µg/kg mouse recombinant IL-22 for seven days attenuated adverse ventricular remodeling and improved cardiac function in mice at 28 days after left anterior descending coronary artery ligation-induced MI. Pharmacological inhibition of signal transducer and activator of transcription (STAT3) muted these IL-22 activities. While cardiomyocyte-selective depletion of STAT3 did not affect IL-22 activities in protecting post-MI cardiac injury, hepatocyte-specific depletion of STAT3 fully muted these IL-22 cardioprotective activities. Hepatocyte-derived fibroblast growth factor (FGF21) was markedly increased in a STAT3-dependent manner following IL-22 administration and accounted for the cardioprotective benefit of IL-22. Microarray analyses revealed that FGF21 controlled the expression of cardiomyocyte genes that are involved in cholesterol homeostasis, DNA repair, peroxisome, oxidative phosphorylation, glycolysis, apoptosis, and steroid responses, all of which are responsible for cardiomyocyte survival. Conclusions: Supplementation of IL-22 in the first week after acute MI effectively prevented left ventricular dysfunction and heart failure. This activity of IL-22 involved crosstalk between the liver and heart after demonstrating a role of the hepatic STAT3-FGF21 axis in IL-22-induced post-MI cardiac protection
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