Generalized fractional maximal and integral operators on Orlicz and generalized Orlicz--Morrey spaces of the third kind

In the present paper, we will characterize the boundedness of the generalized fractional integral operators $I_{\rho}$ and the generalized fractional maximal operators $M_{\rho}$ on Orlicz spaces, respectively. Moreover, we will give a characterization for the Spanne-type boundedness and the Adams-type boundedness of the operators $M_{\rho}$ and $I_{\rho}$ on generalized Orlicz--Morrey spaces, respectively. Also we give criteria for the weak versions of the Spanne-type boundedness and the Adams-type boundedness of the operators $M_{\rho}$ and $I_{\rho}$ on generalized Orlicz--Morrey spaces

Effectiveness and safety of non-vitamin K oral anticoagulants versus warfarin in patients with atrial fibrillation and previous stroke: A systematic review and meta-analysis

Introduction: Current evidence regarding the clinical outcomes of non-vitamin K oral anticoagulants (NOACs) versus warfarin in patients with atrial fibrillation (AF) and previous stroke is inconclusive, especially in patients with previous intracranial haemorrhage (ICrH). We aim to undertake a systematic review and meta-analysis assessing the effectiveness and safety of NOACs versus warfarin in AF patients with a history of stroke. Methods: We searched studies published up to December 10, 2022, on PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials. Studies on adults with AF and previous ischaemic stroke (IS) or IrCH receiving either NOACs or warfarin and capturing outcome events (thromboembolic events, ICrH, and all-cause mortality) were eligible for inclusion. Results: Six randomized controlled trials (RCTs) (including 19,489 patients with previous IS) and fifteen observational studies (including 132,575 patients with previous IS and 13,068 patients with previous ICrH) were included. RCT data showed that compared with warfarin, NOACs were associated with a significant reduction in thromboembolic events (odds ratio [OR]: 0.85, 95% confidence interval [CI]: 0.75-0.96), ICrH (OR: 0.57, 95% CI: 0.36-0.90), and all-cause mortality (OR: 0.88, 95% CI: 0.80-0.98). In analysing observational studies, similar results were retrieved. Moreover, patients with previous ICrH had a lower OR on thromboembolic events than those with IS (OR: 0.66, 95% CI: 0.46-0.95 vs. OR: 0.80, 95% CI: 0.70-0.93) in the comparison between NOACs and warfarin. Conclusions: Observational data showed that in AF patients with previous stroke, NOACs showed better clinical performance compared to warfarin and the benefits of NOACs were more pronounced in patients with previous IrCH versus those with IS. RCT data also showed NOACs are superior to warfarin. However, current RCTs only included AF patients who survived an IS, and further large RCTs focused on patients with previous ICrH are warranted.</p

Quality Investigations on Ground Improvement in Highway Engineering Practice

The constructions of highway often pass through naturally-deposited liquefiable grounds. Anti-earthquake design is essential for highway engineering practice in east China. Gravel column and dynamic compaction are often adopted for the improvements of such problematical grounds. The stability and settlement of the treated grounds depend much on the construction quality. How to investigate the quality of ground improvement is an important issue in highway engineering practice. In this study, the method of Spectral-Analysis-of-Surface-Waves (SASW) is applied to evaluate the construction quality on ground improvements by vibration gravel piles and dynamic compaction technique. The case studies show that the SASW method is a powerful way for investigating the improvement quality in highway engineering practice. The shear wave velocity measured in SASW has a relative good relationship with the N value measured in standard penetration tests

Effectiveness of Dynamic Compaction on Liquefied Foundation in Highway Practice

In this paper, the in-situ dynamic compaction tests with different values of single-drop-compaction energy are performed on a liquefiable ground encountered in highway engineering practice. Excess pore pressure, total surface settlement and lateral deformation under dynamic compaction impact are measured and analyzed at different conditions, such as single drop-compaction-energy, drop numbers, depth of soil layer etc. The standard penetration test (SPT) is used for investigating the compaction effectiveness. The investigation results indicate dynamic compaction technique is an effective way for improving liquefiable ground in highway engineering practice. Relatively small single-drop-compaction energy and relatively more drop numbers should be adopted for improving natural sedimentary liquefiable ground with dynamic compaction. The in-situ dynamic compaction tests show that the effective effect range by dynamic compaction impact depends on the single-drop-compaction energy. It is also found that the measured maximum lateral deformation has a good linear relationship with the total vertical surface settlement

Abscission cues generated within the abscising organ and perceived by the abscission zone in woody fruit crops

From an evolutionary perspective, fruit abscission is an intelligent regulatory mechanism by which fruit trees adapt to their environment and ensure offspring. However, from an agricultural production standpoint, unwanted fruit abscission can cause significant loss in fruit yield and economic value. Therefore, investigating the mechanisms of fruit abscission has always been an important focus in the field of plant research. Acquiring a thorough comprehension of the underlying mechanisms responsible for fruit abscission is highly valuable for enhancing fruit crop breeding and optimizing harvesting practices. In this review, we focus on fruit abscission, particularly discussing the nature of abscission cues within the abscising fruit, how these signals are generated and transmitted, and how the abscission zone cells perceive and respond to these signals in woody fruit crops

Cell Cycle-Dependent Expression Dynamics of G1/S Specific Cyclin, Cellulose Synthase and Cellulase in the Dinoflagellate Prorocentrum donghaiense

Dinoflagellates undergo a typical eukaryotic cell cycle consisting of G1, S, G2, and M phases and some of the typical cell cycle related genes have been computationally identified. However, very few of these genes have been experimentally linked to the cell cycle phases. Besides, although thecate dinoflagellates are known to possess theca composed of cellulose, information on cellulose synthesis and degradation associated with the cell cycle is also limited. In this study, we isolated G1/S cyclin, cellulose synthase and cellulase encoding genes in dinoflagellate Prorocentrum donghaiense. Further, using reverse transcription quantitative PCR (RT-qPCR), we characterized the expression profiles of the three genes throughout the cell cycle. All three showed clear expression dynamics throughout the cell cycle, with fold changes of 26, 2.4 and 9.3 for G1/S cyclin, cellulose synthase and cellulase gene, respectively. The transcript abundance of G1/S cyclin increased in late G1 phase and dropped in early S phase, indicating that this protein is involved in the G1/S transition. Throughout the cell cycle, the average transcript level of cellulose synthase was 4.5-fold higher than that of cellulase. Cellulose synthase and cellulase gene expressions showed peak transcript abundances at middle G1 phase and G2M phase, respectively, indicating the respective roles of these enzymes in the growth of newly divided cells and in cytokinesis. Our results suggest that G1/S cyclin, cellulase, and cellulose synthase genes associated with G1/S transition, G2M, and G1 phases of the cell cycle and are candidates of biomarkers for assessing growth status of P. donghaiense

CTCF Mediates the Cell-Type Specific Spatial Organization of the Kcnq5 Locus and the Local Gene Regulation

Chromatin loops play important roles in the dynamic spatial organization of genes in the nucleus. Growing evidence has revealed that the multivalent functional zinc finger protein CCCTC-binding factor (CTCF) is a master regulator of genome spatial organization, and mediates the ubiquitous chromatin loops within the genome. Using circular chromosome conformation capture (4C) methodology, we discovered that CTCF may be a master organizer in mediating the spatial organization of the kcnq5 gene locus. We characterized the cell-type specific spatial organization of the kcnq5 gene locus mediated by CTCF in detail using chromosome conformation capture (3C) and 3C-derived techniques. Cohesion also participated in mediating the organization of this locus. RNAi-mediated knockdown of CTCF sharply diminished the interaction frequencies between the chromatin loops of the kcnq5 gene locus and down-regulated local gene expression. Functional analysis showed that the interacting chromatin loops of the kcnq5 gene locus can repress the gene expression in a luciferase reporter assay. These interacting chromatin fragments were a series of repressing elements whose contacts were mediated by CTCF. Therefore, these findings suggested that the dynamical spatial organization of the kcnq5 locus regulates local gene expression

A Financial Embedded Vector Model and Its Applications to Time Series Forecasting

Inspired by the embedding representation in Natural Language Processing (NLP), we develop a financial embedded vector representation model to abstract the temporal characteristics of financial time series. Original financial features are discretized firstly, and then each set of discretized features is considered as a “word” of NLP, while the whole financial time series corresponds to the “sentence” or “paragraph”. Therefore the embedded vector models in NLP could be applied to the financial time series. To test the proposed model, we use RBF neural networks as regression model to predict financial series by comparing the financial embedding vectors as input with the original features. Numerical results show that the prediction accuracy of the test data is improved for about 4-6 orders of magnitude, meaning that the financial embedded vector has a strong generalization ability

Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models

Background Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer clinical application, indicating some type of immunogenicity and toxicity. Cyclization is commonly used to improve the in vivo stability and activity of peptides and proteins. Methods We designed and constructed cyclic entolimod using split Nostoc punctiforme DnaE intein with almost 100% cyclization efficiency. We adopted different strategies to purify the linear and circular entolimod due to their different topologies. Both of linear and circular entolimod were first purified by Ni-chelating affinity chromatography, and then the linear and circular entolimod were purified by size-exclusion and ion-exchange chromatography, respectively. Results The circular entolimod showed significantly increased both the in vitro NF-κB signaling and in vivo radioprotective activity in mice. Conclusion Our data indicates that circular entolimod might be a good candidate for further clinical investigation