4-{2-[(3,4-Dichloro­phen­yl)(meth­yl)amino]-4-methyl-1,3-thia­zol-5-yl}-N-(3-methyl­phen­yl)pyrimidin-2-amine

In the title compound, C22H19Cl2N5S, the thia­zole and pyrimidine rings are almost co-planar, making a dihedral angle of 6.48 (7)°. In the crystal, intermolecular N—H⋯N hydrogen bonds link pairs of molecules into centrosymmetric dimers.

N-(3-Meth­oxy­phen­yl)-4-{4-methyl-2-[(meth­yl)(4-methyl­phen­yl)amino]-1,3-thia­zol-5-yl}pyrimidin-2-amine

The asymmetric unit of the title compound, C23H23N5OS, contains two independent mol­ecules. In one mol­ecule, the thia­zole and pyrimidine rings are almost co-planar, making a dihedral angle of 2.48 (8)°. In the other mol­ecule, the corresponding dihedral angle is 12.82 (8)°. The crystal structure is stabilized by weak inter­molecular N—H⋯N and C—H⋯O inter­actions that extend along the b axis

Ground state properties of a Tonks-Girardeau Gas in a periodic potential

In this paper, we investigate the ground-state properties of a bosonic Tonks-Girardeau gas confined in a one-dimensional periodic potential. The single-particle reduced density matrix is computed numerically for systems up to $N=265$ bosons. Scaling analysis of the occupation number of the lowest orbital shows that there are no Bose-Einstein Condensation(BEC) for the periodically trapped TG gas in both commensurate and incommensurate cases. We find that, in the commensurate case, the scaling exponents of the occupation number of the lowest orbital, the amplitude of the lowest orbital and the zero-momentum peak height with the particle numbers are 0, -0.5 and 1, respectively, while in the incommensurate case, they are 0.5, -0.5 and 1.5, respectively. These exponents are related to each other in a universal relation.Comment: 9 pages, 10 figure

4-{4-Methyl-2-[(meth­yl)(2-methyl­phen­yl)amino]-1,3-thia­zol-5-yl}-N-(3-methyl­phen­yl)pyrimidin-2-amine

In the title compound, C23H23N5S, the thia­zole ring and pyrimidine ring are almost coplanar, making a dihedral angle of 4.02 (9)°. in the crystal, weak inter­molecular N—H⋯N inter­actions link pairs of molecules into centrosymmetric dimers

N-(3,4-Dichloro­phen­yl)thio­urea

In the title compound, C7H6Cl2N2S, the benzene ring and the mean plane of the thio­urea fragment [—N—C(=S)—N] make a dihedral angle of 66.77 (3)°. Inter­molecular N—H⋯S and N—H⋯Cl hydrogen bonds link the mol­ecules into a three-dimensional network

2,2,2-Trifluoro­ethyl 4-methyl­benzene­sulfonate

In the crystal structure of the title compound, C9H9F3O3S, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules along the c-axis direction. Also present are slipped π–π stacking inter­actions between phenyl­ene rings, with perpendicular inter­planar distances of 3.55 (2) Å and centroid–centroid distances of 3.851 (2) Å

Methyl 2-amino-5-chloro­benzoate

The title compound, C8H8ClNO2, is almost planar, with an r.m.s. deviation of 0.0410 Å from the plane through the non-hydrogen atoms. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains along the b axis. An intra­molecular N—H⋯O hydrogen bond results in the formation of a six-membered ring

Inhibitory effects of adenovirus mediated tandem expression of RhoA and RhoC shRNAs in HCT116 cells

<p>Abstract</p> <p>Background</p> <p>RhoA and RhoC are deregulated by over expression in many human tumors, including colorectal cancer. Some reports show that they play a pivotal role in the carcinogenesis, tumor development and infiltration metastasis. In this study, for the first time we constructed recombinant adenovirus to investigate the inhibitory effects of RhoA and RhoC shRNAs in tandem expression on the cell proliferation and invasion of colorectal cancer HCT116 cells.</p> <p>Methods</p> <p>The recombinant adenovirus carrying RhoA and RhoC shRNAs in tandem expression was transfected into HCT116. The mRNA transcription and protein expressions of RhoA and RhoC were examined by RT-FQPCR and Western blot respectively. Cellular proliferation inhibitory activity was determined by methyl thiazolyl tetrazolium (MTT) assay and invasive and migrating potential was detected through in vitro Matrigel coated invasion and migration assay.</p> <p>Results</p> <p>Both mRNA and proteins Levels of RhoA and RhoC were significantly reduced in HCT116 cells transfected with Ad-A1+A2+C1+C2 than those in Ad-HK group and control one. The relative RhoA and RhoC mRNA transcriptions were decreased to 40% and 36% (P < 0.05), while proteins expression reducing 42% and 35%, respectively (P < 0.05). Growth curves analysis showed that alive cell number in the Ad-A1+A2+C1+C2 group was lower than others in the third to sixth day and transwell chamber analysis showed that migration/invasion activity was significantly suppressed in Ad-A1+A2+C1+C2 group.</p> <p>Conclusion</p> <p>Our results indicate recombinant adenovirus carrying RhoA and RhoC shRNAs in tandem expression may inhibit the growth and invasion of HCT116 cells. Application of such vector to inhibit one or more genes may be a new method to cancer therapy.</p