Circulating levels of prolactin in human breast cancer.

Serum prolactin concentrations were measured by radioimmunoassays in 98 patients with established carcinoma of breast, 12 patients with cystic mastitis and 10 patients with gynaecomastia and compared with that of age matched normal control women. The serum prolactin levels in the patients with breast cancer, gynaecomastia or cystic mastitis were observed to be similar to that in normal women. It was interesting to note that the levels of prolactin in the luteal phase of the cycle were higher than that in the early follicular phase in normal women

Studies on immunocytochemical localization of inhibin-like material in human prostatic tissue: comparison of its distribution in normal, benign and malignant prostates.

A specific antiserum has been generated against inhibin-like material (ILM) of prostatic origin. Using the immunoperoxidase technique, localization of ILM has been examined in a total of 114 prostates including normal (4 specimens), malignant (46) and hyperplastic (55) tissues. ILM positive immunocytochemical reactions were confined to the cytoplasm and not the nucleus of the prostatic acinar cells in the three categories of prostate, whereas the stroma showed negative reactions. The intensity of positive reactions decreased in the following order: Hyperplasia, incidental and moderately differentiated carcinomas, poorly differentiated carcinomas, whereas metaplasia and granulomatous prostatitis gave negative reactions for ILM. Using this experimental protocol, 200 non-prostatic tissue were found to be completely negative, demonstrating the specificity of the test for prostatic epithelium. These findings indicate a potential use of ILM as a marker of prostatic tissue

Ectopic production of human placental lactogen by human breast tumors

Serum samples from 72 patients with established carcinoma of the breast were investigated for ectopic presence of hPL. Further, the relationship of ectopically-secreted hPL and hCG-β in breast cancer was investigated. Ten of 72 patients examined had detectable hPL and 12 had detectable hCG-β, at 1-2 ng/ml serum sensitivity of the assay. The presence of hPL in serum of breast cancer patients was found to be independent of that of hCG-β. Sera of 13 patients with cystic mastitis, five with fibroadenoma, two with acute inflamation of breast, 20 normal women (non-pregnant) and 20 normal men did not show any detectable serum hPL or hCG-β at the above mentioned sensitivity of the assay. Since these hormones were not detectable in normal men, normal non-pregnant women, and in patients having other pathological conditions of breast, the possible use of them as markers in cancer is expected

Redshift space 21 cm power spectra from reionization

We construct a simple but self-consistent analytic ionization model for rapid exploration of 21cm power spectrum observables in redshift space. It is fully described by the average ionization fraction $x_e(z)$ and HII patch size $R(z)$ and has the flexibility to accommodate various reionization scenarios. The model associates ionization regions with dark matter halos of the number density required to recover $x_e$ and treats redshift space distortions self-consistently with the virial velocity of such halos. Based on this model, we study the line-of-sight structures in the brightness fluctuations since they are the most immune to foreground contamination. We explore the degeneracy between the HII patch size and nonlinear redshift space distortion in the one dimensional power spectrum. We also discuss the limitations experimental frequency and angular resolutions place on their distinguishability. Angular resolution dilutes even the radial signal and will be a serious limitation for resolving small bubbles before the end of reionization. Nonlinear redshift space distortions suggest that a resolution of order 1 -- 10\arcsec and a frequency resolution of 10kHz will ultimately be desirable to extract the full information in the radial field at $z\sim 10$. First generation instruments such as LOFAR and MWA can potentially measure radial HII patches of a few comoving Mpc and larger at the end of reionization and are unlikely to be affected by nonlinear redshift space distortions.Comment: 13 pages, 10 figures. Revised version. Includes minor changes. Adds appendix on accomodating a distribution of radii for the HII regions. Accepted for publication in Ap

Nonlinear Velocity-Density Coupling: Analysis by Second-Order Perturbation Theory

Cosmological linear perturbation theory predicts that the peculiar velocity $V(x)$ and the matter overdensity $\delta(x)$ at a same point $x$ are statistically independent quantities, as log as the initial density fluctuations are random Gaussian distributed. However nonlinear gravitational effects might change the situation. Using framework of second-order perturbation theory and the Edgeworth expansion method, we study local density dependence of bulk velocity dispersion that is coarse-grained at a weakly nonlinear scale. For a typical CDM model, the first nonlinear correction of this constrained bulk velocity dispersion amounts to $\sim 0.3\delta$ (Gaussian smoothing) at a weakly nonlinear scale with a very weak dependence on cosmological parameters. We also compare our analytical prediction with published numerical results given at nonlinear regimes.Comment: 16 pages including 2 figures, ApJ 537 in press (July 1

An excursion set model of the cosmic web: The abundance of sheets, filaments and halos

We discuss an analytic approach for modeling structure formation in sheets, filaments and knots. This is accomplished by combining models of triaxial collapse with the excursion set approach: sheets are defined as objects which have collapsed along only one axis, filaments have collapsed along two axes, and halos are objects in which triaxial collapse is complete. In the simplest version of this approach, which we develop here, large scale structure shows a clear hierarchy of morphologies: the mass in large-scale sheets is partitioned up among lower mass filaments, which themselves are made-up of still lower mass halos. Our approach provides analytic estimates of the mass fraction in sheets, filaments and halos, and its evolution, for any background cosmological model and any initial fluctuation spectrum. In the currently popular $\Lambda$CDM model, our analysis suggests that more than 99% of the cosmic mass is in sheets, and 72% in filaments, with mass larger than $10^{10} M_{\odot}$ at the present time. For halos, this number is only 46%. Our approach also provides analytic estimates of how halo abundances at any given time correlate with the morphology of the surrounding large-scale structure, and how halo evolution correlates with the morphology of large scale structure.Comment: 22 pages, 7 figures, Accepted for publication in Ap