Геотермические условия газонефтеводоносных комплексов Пермско-Башкирского свода в пределах Пермского края

Интерес к геотермическим исследованиям обусловлен общепризнанным значением температуры недр как важнейшего фактора нефтегазообразования, миграции и преобразований подземных флюидов, как одного из важных показателей распределения естественных и искусственных тепловых свойств пород по площади и с глубиной. На территории Пермского края в пределах Пермско-Башкирского свода геотермические исследования осадочного разреза проведены на 251 площади. Рассмотрены особенности изменения геотермических условий с глубиной и по площади. Проведен сравнительный анализ геотермических показателей исследованных площадей: температуры, геотермического градиента, геотермической ступени. По геотермическим показателям выявлены перспективные площади на нефть и газ.</p

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Rational in the Political Myth of «Loyalty»

In the article the connections between the level of political subjectivity of the participants of Russian political process and the loyalty of their attitude to the acting supreme state power are analyzed. Loyalty is considered to be a political and mythological determinative of the political relationship from the historical and modern point of view

Geothermal Conditions of the Gas- Oil- and Water-bearing Formations of Perm-Bashkirian Arch in Perm Kray

Интерес к геотермическим исследованиям обусловлен общепризнанным значением температуры недр как важнейшего фактора нефтегазообразования, миграции и преобразований подземных флюидов, как одного из важных показателей распределения естественных и искусственных тепловых свойств пород по площади и с глубиной. На территории Пермского края в пределах Пермско-Башкирского свода геотермические исследования осадочного разреза проведены на 251 площади. Рассмотрены особенности изменения геотермических условий с глубиной и по площади. Проведен сравнительный анализ геотермических показателей исследованных площадей: температуры, геотермического градиента, геотермической ступени. По геотермическим показателям выявлены перспективные площади на нефть и газ.The temperature studying is very important for determination of the oil and gas genesis conditions, understanding the migration and transformation of the underground fluids, assessment of distribution of the thermal characteristics in the rock. On the territory of Perm-Bashkirian Arch in Perm kray, the geothermal observation of the sedimentary cover were curried out on 251 sites. The depth and lateral distribution of the geothermal conditions is discussed. Based on the comparative analysis of temperature, geothermal gradient, and geothermal step at the studied sites, the areas perspective for oil and gas exploration were revealed

Associations of mortality relative risk, smoking status, alcohol intake, and educational level in women

The authors assess relative risk (RR) of coronary heart disease (CHD), stroke (S), cardiovascular disease (CVD), and total mortality, according to smoking status, alcohol intake, and educational level in women. In ex-smokers and current smokers, mortality RR was significantly and dose-dependently increased. In occasional and low-dose drinkers, RR of CVD, CHD, and total mortality was reduced. At the same time, in moderate drinkers, RR was similar to that in frequent and high-dose drinkers. Mortality RR was inversely linked to educational level: in highly educated women, RR was substantially lower than in participants with lower educational levels. The authors assess relative risk (RR) of coronary heart disease (CHD), stroke (S), cardiovascular disease (CVD), and total mortality, according to smoking status, alcohol intake, and educational level in women. In ex-smokers and current smokers, mortality RR was significantly and dose-dependently increased. In occasional and low-dose drinkers, RR of CVD, CHD, and total mortality was reduced. At the same time, in moderate drinkers, RR was similar to that in frequent and high-dose drinkers. Mortality RR was inversely linked to educational level: in highly educated women, RR was substantially lower than in participants with lower educational levels