iSchools and archival studies

Whispers and rumors about the iSchool movement lead some to fear that this represents yet another shift away from the valued traditions of library schools, threatening something far different than what library science pioneers ever envisioned. Predating the iSchool movement, however, were other programmatic shifts such as those that led to the formalization of graduate archival education. This essay argues that such evolution is essential to our future, as iSchools tackle the increasingly complex issues confronting a digital society. We consider the mission and history of iSchools and of archival studies, the basic elements and concepts of archival studies that are critical to iSchools, and the relationship between iSchools and the changing nature of personal and institutional archives. © 2009 Springer Science+Business Media B.V

Rapid sequencing of DNA based on single molecule detection

Sequencing the human genome is a major undertaking considering the large number of nucleotides present in the genome and the slow methods currently available to perform the task. We have recently reported on a scheme to sequence DNA rapidly using a non-gel based technique. The concept is based upon the incorporation of fluorescently labeled nucleotides into a strand of DNA, isolation and manipulation of a labeled DNA fragment and the detection of single nucleotides using ultra-sensitive laser-induced fluorescence detection following their cleavage from the fragment. Detection of individual fluorophores in the liquid phase was accomplished with time-gated detection following pulsed-laser excitation. The photon bursts from individual rhodamine 6G (R6G) molecules travelling through a laser beam have been observed as have bursts from single fluorescently modified nucleotides. Using two different biotinylated nucleotides as a model system for fluorescently labeled nucleotides, we have observed synthesis of the complementary copy of M13 bacteriophage. Work with fluorescently labeled nucleotides is underway. We have observed and manipulated individual molecules of DNA attached to a microbead with an epifluorescence microscope. 16 refs., 3 figs., 1 tab

Staggering of the Nuclear Charge Radii in a Superfluid Model with Good Particle Number

A simple superfluid model with an effective four body interaction of monopole pairing type is used to explain the staggering of the charge radii in the isotope chains. The contribution of deformation and of the particle number projection are analyzed for the Sn isotopes. Good results are obtained for the staggering parameters and neutron pairing energies.Comment: RevTex, 19 pages and 4 postscript figures uuencoded and attached. To appear in Phys. Rev.

Deep-underground dark matter search with a COSINUS detector prototype

Sodium iodide (NaI) based cryogenic scintillating calorimeters using quantum sensors for signal read out have shown promising first results towards a model-independent test of the annually modulating signal detected by the DAMA/LIBRA dark matter experiment. The COSINUS collaboration has previously reported on the first above-ground measurements using a dual channel readout of phonons and light based on transition edge sensors (TESs) that allows for particle discrimination on an event-by-event basis. In this letter, we outline the first underground measurement of a NaI cryogenic calorimeter read out via the novel remoTES scheme. A 3.67 g NaI absorber with an improved silicon light detector design was operated at the Laboratori Nazionali del Gran Sasso, Italy. A significant improvement in the discrimination power of $e^-$/$\gamma$-events to nuclear recoils was observed with a five-fold improvement in the nuclear recoil baseline resolution, achieving $\sigma$ = 441 eV. Furthermore, we present a limit on the spin-independent dark-matter nucleon elastic scattering cross-section achieving a sensitivity of $\mathcal{O}$(pb) with an exposure of only 11.6 g d.Comment: 11 pages, 14 figure

Signal Transmission in the Auditory System

Contains table of contents for Section 3, an introduction and reports on six research projects.National Institutes of Health Grant RO1-DC-00194-11National Institutes of Health Grant PO1-DC00119 Sub-Project 1National Institutes of Health Grant F32-DC00073-3National Institutes of Health Contract P01-DC00119National Institutes of Health Grant R01 DC00238National Institutes of Health Grant P01-DC00119National Institutes of Health Grant T32-DC00038National Institutes of Health Contract P01-DC00361National Institutes of Health Grant R01-DC00235National Institutes of Health Contract NO1-DC2240

Evaluating a team-based approach to research capacity building using a matched-pairs study design

Background: There is a continuing need for research capacity building initiatives for primary health care professionals. Historically strategies have focused on interventions aimed at individuals but more recently theoretical frameworks have proposed team-based approaches. Few studies have evaluated these new approaches. This study aims to evaluate a team-based approach to research capacity building (RCB) in primary health using a validated quantitative measure of research capacity in individual, team and organisation domains