Bioengineered Bile Duct: the project resume and state of the art in 2018

Aim. Development of the physiologically relevant tissue-engineered graft for repair of bile duct injures (Dyuzheva et al., 2016). <br><br>Conclusions. Designed scaffold showed no cytotoxicity, both BM-MSCs and cholangiocytes migrated into the depth of fibrous material. The constructs was biodegradable in various model mediums: deionized water, phosphate buffer, bile, full culture medium. The next step is pre-clinical trials on rabbits and minipigs for assessment of implantation safety and efficacy. We suppose that this tubular multilayered tissue-engineered construct will be capable to integration in native tissues after implantation and may be used to injured bile duct reparation