Healthy or Not: A Way to Predict Ecosystem Health in GitHub

With the development of open source community, through the interaction of developers, the collaborative development of software, and the sharing of software tools, the formation of open source software ecosystem has matured. Natural ecosystems provide ecological services on which human beings depend. Maintaining a healthy natural ecosystem is a necessity for the sustainable development of mankind. Similarly, maintaining a healthy ecosystem of open source software is also a prerequisite for the sustainable development of open source communities, such as GitHub. This paper takes GitHub as an example to analyze the health condition of open source ecosystem and, also, it is a research area in Symmetry. Firstly, the paper presents the healthy definition of GitHub open source ecosystem health and, then, according to the main components of natural ecosystem health, the paper proposes the health indicators and health indicators evaluation method. Based on the above, the GitHub ecosystem health prediction method is proposed. By analyzing the projects and data collected in GitHub, it is found that, using the proposed evaluation indicators and method, we can analyze the healthy development trend of the GitHub ecosystem and contribute to the stability of ecosystem development

Decomposing and Coupling Saliency Map for Lesion Segmentation in Ultrasound Images

Complex scenario of ultrasound image, in which adjacent tissues (i.e., background) share similar intensity with and even contain richer texture patterns than lesion region (i.e., foreground), brings a unique challenge for accurate lesion segmentation. This work presents a decomposition-coupling network, called DC-Net, to deal with this challenge in a (foreground-background) saliency map disentanglement-fusion manner. The DC-Net consists of decomposition and coupling subnets, and the former preliminarily disentangles original image into foreground and background saliency maps, followed by the latter for accurate segmentation under the assistance of saliency prior fusion. The coupling subnet involves three aspects of fusion strategies, including: 1) regional feature aggregation (via differentiable context pooling operator in the encoder) to adaptively preserve local contextual details with the larger receptive field during dimension reduction; 2) relation-aware representation fusion (via cross-correlation fusion module in the decoder) to efficiently fuse low-level visual characteristics and high-level semantic features during resolution restoration; 3) dependency-aware prior incorporation (via coupler) to reinforce foreground-salient representation with the complementary information derived from background representation. Furthermore, a harmonic loss function is introduced to encourage the network to focus more attention on low-confidence and hard samples. The proposed method is evaluated on two ultrasound lesion segmentation tasks, which demonstrates the remarkable performance improvement over existing state-of-the-art methods.Comment: 18 pages, 18 figure

Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer

Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). Methods Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. Results Negative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017). Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016). Conclusion Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC

Two-Party Attribute-Based Key Agreement Protocol with Constant-Size Ciphertext and Key

Based on mutual authentication, the session key is established for communication nodes on the open network. In order to satisfy fine-grained access control for cloud storage, the two-party attribute-based key agreement protocol (TP-AB-KA) was proposed. However, the existing TP-AB-KA protocol is high in the cost of computation and communication and is not unfit for application in a mobile cloud setting because mobile devices are generally resource constrained. To solve the above issue, we propose a TP-AB-KA protocol with constant-size ciphertext and key. Our TP-AB-KA protocol is provable security in the standard model. The concrete proof is given under the augmented multisequence of exponents' decisional Diffie-Hellman (aMSE-DDH) hypothesis in the attribute-based BJM model (AB-BJM). Compared with the existing TP-AB-KA protocols, the computation cost and communication cost of our protocol are largely reduced

A Compact Broadband Monolithic Sub-Harmonic Mixer Using Multi-Line Coupler

A compact broadband monolithic sub-harmonic mixer is presented in a 70 nm GaAs Technology for millimeter wave wireless communication application. The proposed mixer adopts a novel multi-line coupler structure; where the two-sided coupling energy of radio frequency (RF) and local oscillation (LO) signals are both collected and efficiently feed to anti-parallel diode pair (APDP) topology; resulting in broadband performance and compact chip size. As a comparison in the same circuit configuration; the five-line coupler can expand the bandwidth of the existing three-line coupler by 85% and reduce the area by 39.5% when the central frequency is 127 GHz. The measured conversion gain is −16.2 dB to −19.7 dB in a wide operation frequency band of 110–170 GHz. The whole chip size is 0.47 × 0.66 mm2 including test pads. The proposed mixer exhibits good figure-of-merits for D-band down-converter application

Adaptive changes of gastro-fntero-pancreatic system endocrine cells in the black-spotted pond frog Rana nigromaculata after fasting

Changes in distribution density, morphology and secretory content of endocrine cells in the gastro-entero-pancreatic system of black-spotted frogs Rana nigromaculata before and after fasting were investigated using immunohistochemistry and antisera to six gut hormones. Six types of endocrine cells were detected in the digestive tract of Rana nigromaculata, including 5-hydroxytryptamine (5-HT), gastrin (GAS), somatostatin (SOM), glucagon (GLU), pancreatic polypeptide (PP) and vasoactive intestinal polypeptide (VIP) cells. After fasting, the density of 5-HT cells in the esophagus, cardia and fundus, GAS cells in fundus and pylorus, PP cells in the fundus decreased significantly(P 0.05), while SOM, GAS, GLU and PP cells increased significantly (P <0.01). Furthermore, the secretory content of GLU cells increased significantly. Considering their functionalities, our results indicate that the changes of GEP endocrine cells in Rana nigromaculata responded adaptively to starvation-induced stress [Current Zoology 55 (4):301–308, 2009]

A selective fluorescent sensor for imaging Cu\u3csup\u3e2+\u3c/sup\u3e in living cells

Copper ion is a biochemically essential yet toxic metal ion, connected to serious neurodegenerative diseases, and also has been identified as an environmental pollutant. For the effective detection of Cu2+ in biological and environmental systems, we have developed a new membrane-permeable Cu2+-selective water-soluble BODIPY 1, which was synthesized by nucleophilic disubstitution of novel 3,5-diiodo-BODIPY 4 with N,N-bis(2-hydroxyethyl)amines. BODIPY 1 shows a highly sensitive and selective fluorescence response to Cu2+ in aqueous solution. Fluorescence image experiments establish that 1 can be used to monitor intracellular Cu 2+ within living cells. © 2009 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique

Analysis of circulating tumor DNA identifies distinct therapeutic response to intraperitoneal and intravenous paclitaxel plus S-1 in gastric cancer patients with peritoneal metastasis

Background: Circulating tumor DNA (ctDNA) is a promising technique for predicting curative effects and monitoring tumor recurrence. The utility of ctDNA for gastric cancer with peritoneal dissemination remains elusive. Objectives: To assess the feasibility of ctDNA in predicting tumor response to chemotherapy in gastric cancer with peritoneal dissemination. Design: This was a prospective study. Methods: We enrolled 30 patients with gastric cancer peritoneal metastasis, treated with intraperitoneal and intravenous paclitaxel plus S-1. Peripheral blood samples of patients were prospectively collected at baseline, after treatment initiation accompanied by computed tomography scan and disease progression. Mutational profiles from ctDNA were analyzed to evaluate its association with chemotherapeutic response. Results: Tumor protein 53 ( TP53 ) was the most frequently altered gene at baseline blood samples. Although baseline TP53 mutation was not related to therapeutic response, patients with TP53 mutation had worse progression-free survival (PFS) and overall survival (OS). Additionally, baseline ctDNA content fraction (CCF) was found to be significantly lower in responders than non-responders. Meanwhile, patients with high CCF had a trend of worse PFS and OS. Combining TP53 alteration and CCF, the prognosis of TP53 -wt patients could be further stratified. Patients with CCF-low_ TP53 -wt had markedly longer survival than those with CCF-high_ TP53 -wt. Conclusion: Our study highlighted the significance of ctDNA in predicting potential clinical outcomes in gastric cancer patients during chemotherapy. Trial registration: ChiCTR-IIR-16009802 (Chinese Clinical Trial Registry)