1 research outputs found
Chrysamides A–C, Three Dimeric Nitrophenyl <i>trans</i>-Epoxyamides Produced by the Deep-Sea-Derived Fungus <i>Penicillium chrysogenum</i> SCSIO41001
Three dimeric nitrophenyl <i>trans</i>-epoxyamides, chrysamides
A–C (<b>1</b>–<b>3</b>), were obtained from
the deep-sea-derived fungus <i>Penicillium chrysogenum</i> SCSIO41001. Their structures were characterized by spectroscopic
analysis, electronic circular dichroism computations, and X-ray single-crystal
diffraction analysis. Notably, compound <b>1</b> possesses a
novel centrosymmetric dimer skeleton featuring an unprecedented 7-oxa-2,5-diazabicyclo[2.2.1]Âheptane
ring system, which represents the first example of dimeric nitrophenyl <i>trans</i>-epoxyamide in nature. Compound <b>3</b> suppresses
the production of proinflammatory cytokine interleukin-17. A possible
biosynthetic pathway of <b>1</b>–<b>3</b> was proposed