1 research outputs found
Hepatoprotective Activity and Mechanisms of Prenylated Stilbenoids
Dietary prenylated stilbenoids, found
in various food
sources,
offer multiple health benefits, including liver protection. However,
the underlying mechanisms of hepatoprotection remain unclear. In this
study, we synthesized 13 natural prenylated stilbenoids and examined
their hepatoprotective activities, with silent mating type information
regulation 2 homologue-1 (SIRT1) as the primary target for screening.
Among all of the prenylated stilbenoids tested, 4-C-geranyl oxyresveratrol demonstrated superior performance. It activated
SIRT1 activity more effectively than resveratrol, a well-known SIRT1
activator. To further investigate the mechanism of liver protection,
two in vitro models were used: the palmitic acid-induced
lipid accumulation model and the H2O2-induced
apoptosis model. Our findings suggested that 4-C-geranyl
oxyresveratrol mitigated lipid accumulation through the SIRT1-PGC1α
pathway, reduced apoptosis via the SIRT1-p53-p21 pathway, and exerted
antioxidant effects through the SIRT1-Nrf2 pathway. These findings
provide new insights into the chemical basis of the health benefits
of prenylated stilbenoids and their potential use as functional food
additives