Probability Thermodynamics and Probability Quantum Field

In this paper, we introduce probability thermodynamics and probability quantum fields. By probability we mean that there is an unknown operator, physical or nonphysical, whose eigenvalues obey a certain statistical distribution. Eigenvalue spectra define spectral functions. Various thermodynamic quantities in thermodynamics and effective actions in quantum field theory are all spectral functions. In the scheme, eigenvalues obey a probability distribution, so a probability distribution determines a family of spectral functions in thermodynamics and in quantum field theory. This leads to probability thermodynamics and probability quantum fields determined by a probability distribution. There are two types of spectra: lower bounded spectra, corresponding to the probability distribution with nonnegative random variables, and the lower unbounded spectra, corresponding to probability distributions with negative random variables. For lower unbounded spectra, we use the generalized definition of spectral functions. In some cases, we encounter divergences. We remove the divergence by a renormalization procedure. Moreover, in virtue of spectral theory in physics, we generalize some concepts in probability theory. For example, the moment generating function in probability theory does not always exist. We redefine the moment generating function as the generalized heat kernel, which makes the concept definable when the definition in probability theory fails. As examples, we construct examples corresponding to some probability distributions. Thermodynamic quantities, vacuum amplitudes, one-loop effective actions, and vacuum energies for various probability distributions are presented

Further Study On U(1) Gauge Invariance Restoration

To further investigate the applicability of the projection scheme for eliminating the unphysical divergence $s/m_e^2$ due to U(1) gauge invariance violation, we study the process $e^-+W^+\to e^-+\bar t+b$ which possesses advantages of simplicity and clearness. Our study indicates that the projection scheme can indeed eliminate the unphysical divergence $s/m_e^2$ caused by the U(1) gauge invariance violation and the scheme can apply to very high energy region.Comment: Latex, 13 pages, 4 EPS fiure

The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells

AbstractThe C-Jun N-terminal Kinase (JNK) inhibitor SP600125 is widely used to inhibit the JNK-mediated Bax activation and cell apoptosis. However, this report demonstrates that SP600125 synergistically enhances the dihydroartemisinin (DHA)-induced human lung adenocarcinoma cell apoptosis by accelerating Bax translocation and subsequent intrinsic apoptotic pathway involving mitochondrial membrane depolarization, cytochrome c release, caspase-9 and caspase-3 activation. The dynamical analysis of GFP-Bax mobility inside single living cells using fluorescence recovery after photobleaching revealed that SP600125 aggravated the DHA-induced decrease of Bax mobility and Bax translocation. These results for the first time present a novel pro-apoptotic action of SP600125 in DHA-induced apoptosis

Identification of Hub Genes Associated With Progression and Prognosis in Patients With Bladder Cancer

Given that most bladder cancers (BCs) are diagnosed in advanced stages with poor prognosis, this study aims to find novel biomarkers associated with the progression and prognosis in patients with BC. 1,779 differentially expressed genes (DEGs) between BC samples and normal bladder tissues were identified in total. Then, 24 DEGs were regarded as candidate hub genes by constructing a protein–protein interaction (PPI) network and a random forest model. Among them, six genes (BUB1B, CCNB1, CDK1, ISG15, KIF15, and RAD54L) were eventually identified by using five analysis methods (one-way Analysis of Variance analysis, spearman correlation analysis, distance correlation analysis, receiver operating characteristic curve, and expression values comparison), which were correlated with the progression and prognosis of BC. Moreover, the validation of hub genes was conducted based on GSE13507, Oncomine, and CBioPortal. Results of univariate Cox regression analysis showed that the expression levels of all the hub genes were influence features of overall survival (OS) and cancer specific survival (CSS) based on GSE13507, and we further established a six-gene signature based on the expression levels of the six genes and their Cox regression coefficients. This signature showed good potential for clinical application suggested by survival analysis (OS: Hazard Ratio = 0.484, 95%CI: 0.298–0.786; P = 0.0034; CSS: Hazard Ratio = 0.244, 95%CI: 0.121–0.493, P < 0.0001) and decision curve analysis. In conclusion, our study indicates that six hub genes have great predictive value for the prognosis and progression of BC and may contribute to the exploration of further basic and clinical research of BC

Proteomic identification of OsCYP2, a rice cyclophilin that confers salt tolerance in rice (Oryza sativa L.) seedlings when overexpressed

<p>Abstract</p> <p>Background</p> <p>High Salinity is a major environmental stress influencing growth and development of rice. Comparative proteomic analysis of hybrid rice shoot proteins from Shanyou 10 seedlings, a salt-tolerant hybrid variety, and Liangyoupeijiu seedlings, a salt-sensitive hybrid variety, was performed to identify new components involved in salt-stress signaling.</p> <p>Results</p> <p>Phenotypic analysis of one protein that was upregulated during salt-induced stress, cyclophilin 2 (OsCYP2), indicated that <it>OsCYP2 </it>transgenic rice seedlings had better tolerance to salt stress than did wild-type seedlings. Interestingly, wild-type seedlings exhibited a marked reduction in maximal photochemical efficiency under salt stress, whereas no such change was observed for <it>OsCYP2</it>-transgenic seedlings. <it>OsCYP2</it>-transgenic seedlings had lower levels of lipid peroxidation products and higher activities of antioxidant enzymes than wild-type seedlings. Spatiotemporal expression analysis of <it>OsCYP2 </it>showed that it could be induced by salt stress in both Shanyou 10 and Liangyoupeijiu seedlings, but Shanyou 10 seedlings showed higher <it>OsCYP2 </it>expression levels. Moreover, circadian rhythm expression of <it>OsCYP2 </it>in Shanyou 10 seedlings occurred earlier than in Liangyoupeijiu seedlings. Treatment with PEG, heat, or ABA induced <it>OsCYP2 </it>expression in Shanyou 10 seedlings but inhibited its expression in Liangyoupeijiu seedlings. Cold stress inhibited <it>OsCYP2 </it>expression in Shanyou 10 and Liangyoupeijiu seedlings. In addition, OsCYP2 was strongly expressed in shoots but rarely in roots in two rice hybrid varieties.</p> <p>Conclusions</p> <p>Together, these data suggest that OsCYP2 may act as a key regulator that controls ROS level by modulating activities of antioxidant enzymes at translation level. OsCYP2 expression is not only induced by salt stress, but also regulated by circadian rhythm. Moreover, OsCYP2 is also likely to act as a key component that is involved in signal pathways of other types of stresses-PEG, heat, cold, or ABA.</p

Spectra of Baryons Containing Two Heavy Quarks in Potential Model

In this work, we employ the effective vertices for interaction between diquarks (scalar or axial-vector) and gluon where the form factors are derived in terms of the B-S equation, to obtain the potential for baryons including a light quark and a heavy diquark. The concerned phenomenological parameters are obtained by fitting data of $B^{(*)}-$mesons instead of the heavy quarkonia. The operator ordering problem in quantum mechanics is discussed. Our numerical results indicate that the mass splitting between $B_{3/2}(V), B_{1/2}(V)$ and $B_{1/2}(S)$ is very small and it is consistent with the heavy quark effective theory (HQET).Comment: 16 page

Insights into the Ecological Roles and Evolution of Methyl-Coenzyme M Reductase-Containing Hot Spring Archaea

Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages. Here, we study the mcr-containing archaeal MAGs from several hot springs, which reveal further expansion in the diversity of archaeal organisms performing methane/alkane metabolism. Significantly, an MAG basal to organisms from the phylum Thaumarchaeota that contains mcr genes, but not those for ammonia oxidation or aerobic metabolism, is identified. Together, our phylogenetic analyses and ancestral state reconstructions suggest a mostly vertical evolution of mcrABG genes among methanogens and methanotrophs, along with frequent horizontal gene transfer of mcr genes between alkanotrophs. Analysis of all mcr-containing archaeal MAGs/genomes suggests a hydrothermal origin for these microorganisms based on optimal growth temperature predictions. These results also suggest methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor