Optimizing Task-Specific Timeliness With Edge-Assisted Scheduling for Status Update

Intelligent real-time applications, such as video surveillance, demand intensive computation to extract status information from raw sensing data. This poses a substantial challenge in orchestrating computation and communication resources to provide fresh status information. In this paper, we consider a scenario where multiple energy-constrained devices served by an edge server. To extract status information, each device can either do the computation locally or offload it to the edge server. A scheduling policy is needed to determine when and where to compute for each device, taking into account communication and computation capabilities, as well as task-specific timeliness requirements. To that end, we first model the timeliness requirements as general penalty functions of Age of Information (AoI). A convex optimization problem is formulated to provide a lower bound of the minimum AoI penalty given system parameters. Using KKT conditions, we proposed a novel scheduling policy which evaluates status update priorities based on communication and computation delays and task-specific timeliness requirements. The proposed policy is applied to an object tracking application and carried out on a large video dataset. Simulation results show that our policy improves tracking accuracy compared with scheduling policies based on video content information.Comment: Accepted for publication as a Special Issue: The Role of Freshness and Semantic Measures in the Transmission of Information for Next Generation Networks paper in the IEEE Journal on Selected Areas in Information Theor

Chemical Composition, Antimicrobial and Insecticidal Activities of Essential Oils of Discarded Perfume Lemon and Leaves (Citrus Limon (L.) Burm. F.) as Possible Sources of Functional Botanical Agents

Two essential oils were isolated from discarded perfume lemon and leaves (Citrus limon (L.) Burm. F.) by hydro-distillation with good yield (0.044% for perfume lemon and 0.338% for leaves). Their biological activities were evaluated against five selected bacterial strains and Aedes albopictus (Ae. albopictus, Diptera: Culicidae). Chemical composition indicated that both essential oils were rich in essential phytochemicals including hydrocarbons, monoterpenes and sesquiterpene. These constituents revealed some variability among the oils displaying interesting chemotypes (R)-(+)-limonene (12.29–49.63%), citronellal (5.37–78.70%) and citronellol (2.98–7.18%). The biological assessments proved that the two essential oils had similar effect against bacterial (inhibition zones diameter ranging from 7.27 ± 0.06 to 10.37 ± 0.15 mm; MICs and MBCs ranging from 1.6 to 6.4 mg/mL); against Ae. albopictus larvae (LC(50) ranging from 384.81 to 395.09 ppm) and adult mosquito (LD(50) ranging from 133.059 to 218.962 μg/cm(2)); the activity of the two chemotypes ((R)-(+)-limonene and citronellal): larvae (LC(50) ranging from 267.08 to 295.28 ppm), which were all presented in dose-dependent manners. Through this work, we have showcased that recycling and reusing of agriculture by-products, such as discarded perfume lemon and leaves can produce eco-friendly alternatives in bacterial disinfectants and mosquito control product

Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents

A series of ursolic acid (UA), oleanolic acid (OA) and 18β-glycyrrhetinic acid (GA) derivatives were synthesized by introducing a range of substituted aromatic side-chains at the C-2 position after the hydroxyl group at C-3 position was oxidized. Their antibacterial activities were evaluated in vitro against a panel of four Staphylococcus strains. The results revealed that the introduction of aromatic side-chains at the C-2 position of GA led to the discovery of potent triterpenoid derivatives for inhibition of both drug sensitive and resistant S. aureus, while the other two series derivatives of UA and OA showed no significant antibacterial activity even at high concentrations. In particular, GA derivative showed good potency against all four strains of Staphylococcus (MIC = 1.25 - 5 μmol/L) with acceptable pharmacokinetics properties and low cytotoxicity in vitro. Molecular docking was also performed using S. aureus DNA gyrase structure to rationalize the observed antibacterial activity. Therefore, this series of GA derivatives have strong potential for the development of a new type of triterpenoid antibacterial agent

Adaptive Privacy-Preserving Coded Computing With Hierarchical Task Partitioning

Distributed computing is known as an emerging and efficient technique to support various intelligent services, such as large-scale machine learning. However, privacy leakage and random delays from straggling servers pose significant challenges. To address these issues, coded computing, a promising solution that combines coding theory with distributed computing, recovers computation tasks with results from a subset of workers. In this paper, we propose the adaptive privacy-preserving coded computing (APCC) strategy, which can adaptively provide accurate or approximated results according to the form of computation functions, so as to suit diverse types of computation tasks. We prove that APCC achieves complete data privacy preservation and demonstrate its optimality in terms of encoding rate, defined as the ratio between the computation loads of tasks before and after encoding. To further alleviate the straggling effect and reduce delay, we integrate hierarchical task partitioning and task cancellation into the coding design of APCC. The corresponding partitioning problems are formulated as mixed-integer nonlinear programming (MINLP) problems with the objective of minimizing task completion delay. We propose a low-complexity maximum value descent (MVD) algorithm to optimally solve these problems. Simulation results show that APCC can reduce task completion delay by at least 42.9% compared to other state-of-the-art benchmarks.Comment: 14 pages, 6 figure

Meristem Biology Flourishes Under Mt. Tai

Meristem Biology Flourishes Under Mt. Ta

Research on the Water Ridge and Slamming Characteristics of a Semisubmersible Platform under Towing Conditions

During the towing of semisubmersible platforms, waves impact and superpose in front of the platform to form a ridge shaped “water ridge”, which protrudes near the platform and produces a large slamming pressure. The water ridges occur frequently in the towing conditions of semisubmersible platforms. The wave–slamming on the braces and columns of platform is aggravated due to the water ridges, particularly in rough sea conditions. The effect of water ridges is usually ignored in slamming pressure analysis, which is used to check the structural strengths of the braces and columns. In this paper, the characteristics of the water ridge at the braces of a semisubmersible platform are studied by experimental tests and numerical simulations. In addition, the sensitivity of the water ridge to the wave height and period is studied. The numerical simulations are conducted by a Computational Fluid Dynamics (CFD) method, and their accuracy is validated based on experimental tests. The characteristics of the water ridge and slamming pressure on the braces and columns are studied in different wave conditions based on the validated numerical model. It is found that the wave extrusion is the main reason of water ridge. The wave–slamming pressure caused by the water ridge has an approximately linear increase with the wave height and is sensitive to the wave period. With the increase of the wave period, the wave–slamming pressure on the brace and column of the platform increases first and then decreases. The maximum wave–slamming pressure is found when the wave period is 10 s and the slamming pressure reduces rapidly with an increase of wave period

Biochemical Comparison of dsRNA Degrading Nucleases in Four Different Insects

Double stranded RNAs (dsRNA) degrading nuclease is responsible for the rapid degradation of dsRNA molecules, and thus accounts for variations in RNA interference (RNAi) efficacy among insect species. Here, the biochemical properties and tissue-specific activities of dsRNA degrading nucleases in four insects (Spodoptera litura, Locusta migratoria, Periplaneta americana, and Zophobas atratus) from different orders were characterized using a modified assay method. The results revealed that all insect dsRNA degrading nucleases tested showed high activity in alkaline environments at optimal Mg2+ concentrations and elevated temperatures. We also found that enzymes from different insects varied in terms of their optimal reaction conditions and kinetic parameters. Whole body enzyme activity differed dramatically between insect species, although enzymes with higher substrate affinities (lower Km) were usually balanced by a smaller Vmax to maintain a proper level of degradative capacity. Furthermore, enzyme activities varied significantly between the four tested tissues (whole body, gut, hemolymph, and carcass) of the insect species. All the insects tested showed several hundred-fold higher dsRNA degrading activity in their gut than in other tissues. Reaction environment analysis demonstrated that physiological conditions in the prepared gut fluid and serum of different insects were not necessarily optimal for dsRNA degrading nuclease activity. Our data describe the biochemical characteristics and tissue distributions of dsRNA degrading activities in various insects, not only explaining why oral delivery of dsRNA often produces lower RNAi effects than injection of dsRNA, but also suggesting that dsRNA-degrading activities are regulated by physiological conditions. These results allow for a better understanding of the properties of dsRNA degrading nucleases, and will aid in the development of successful RNAi strategies in insects

Research on the Water Ridge and Slamming Characteristics of a Semisubmersible Platform under Towing Conditions

During the towing of semisubmersible platforms, waves impact and superpose in front of the platform to form a ridge shaped “water ridge”, which protrudes near the platform and produces a large slamming pressure. The water ridges occur frequently in the towing conditions of semisubmersible platforms. The wave–slamming on the braces and columns of platform is aggravated due to the water ridges, particularly in rough sea conditions. The effect of water ridges is usually ignored in slamming pressure analysis, which is used to check the structural strengths of the braces and columns. In this paper, the characteristics of the water ridge at the braces of a semisubmersible platform are studied by experimental tests and numerical simulations. In addition, the sensitivity of the water ridge to the wave height and period is studied. The numerical simulations are conducted by a Computational Fluid Dynamics (CFD) method, and their accuracy is validated based on experimental tests. The characteristics of the water ridge and slamming pressure on the braces and columns are studied in different wave conditions based on the validated numerical model. It is found that the wave extrusion is the main reason of water ridge. The wave–slamming pressure caused by the water ridge has an approximately linear increase with the wave height and is sensitive to the wave period. With the increase of the wave period, the wave–slamming pressure on the brace and column of the platform increases first and then decreases. The maximum wave–slamming pressure is found when the wave period is 10 s and the slamming pressure reduces rapidly with an increase of wave period

The role of atorvastatin in suppressing tumor growth of uterine fibroids

Abstract Background Medical therapeutic options remain quite limited for uterine fibroids treatment. Statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, have anti-tumoral effects on multiple cancer types, however, little is known about their effects on uterine fibroids. Methods Initially, we conducted a retrospective study of 120 patients with uterine fibroids and hyperlipidemia from the Second Affiliated Hospital of Wenzhou Medical University. Then, we evaluated the effect of atorvastatin on proliferation and apoptosis both in immortalized uterine fibroids cells and primary uterine fibroids cells. Furthermore, the molecular mechanism by which atorvastatin suppressed uterine fibroids cell growth was explored. Results Our results showed that atorvastatin use for 1 or 2 years significantly suppressed growth of uterine fibroids. Atorvastatin inhibited the proliferation of immortalized and primary uterine fibroids cells in a dose and time-dependent manner and stimulated apoptosis of uterine fibroids cells by inducing caspase-3 activation, up-regulating Bim and down-regulating Bcl-2. Additionally, atorvastatin treatment suppressed phosphorylation of ERK1/2 and JNK. Furthermore, GGPP, a downstream lipid isoprenoid intermediate, significantly rescued the effect of atorvastatin. Conclusions These results suggest that atorvastatin exerts anti-tumoral effects on uterine fibroids through inhibition of cell proliferation and induction of apoptosis in HMG-CoA-dependent pathway. Our results provide the first clinical and preclinical data on the use of atorvastatin as a promising nonsurgical treatment option for uterine fibroids

Electric field modulated ion-sieving effects of graphene oxide membranes

Precise and selective separation of ions using two-dimensional (2D) laminar membranes is a budding research field with potential applications in water treatment, desalination, sensing, biomimicry and energy storage. However, most experiments are designed around pressure or concentration-driven processes without leveraging on the charged nature of ionic species. By applying an electric field across a 2D graphene oxide-based (GO-based) membrane, we demonstrate how ionic selectivity can be enhanced by changing the polarity or increasing the strength of the field. As opposed to traditional permeation experiments, the effects of selectivity are not limited to the membrane itself and can be dynamically tuned during ion removal by changing the strength of the applied electric field. Two types of membranes were investigated in a series of experiments using binary solutions of monovalent and divalent salts. The first is a classical, unmodified GO membrane and the second is a GO membrane with d-spacing restricted by functionalization with ethylenediamine (EDA). Monovalent ion selectivity was detected for both membranes with the EDA-GO membrane achieving a monovalent ion selectivity between 1.5-5 as compared to 1.3-3.5 for the GO membrane. Using density functional theory (DFT) calculations, we determined that the presence of EDA enhanced the formation of K+ and Na+ complexes which would cause distortions in local interlayer distances.</p