Early methodist experience: some prototypical accounts

A great many 20th century studies of 18th century Methodism concern John Wesley himself, and even those which promise to tell you about early Methodist beliefs and activities often turn out to be largely based on Wesley’s alone. Few have concerned themselves with the humble folk who followed him. Yet it is impossible properly to understand even why Wesley himself believed and behaved in the way he did without taking account of the minds and desires of his disciples

Additional file 5: Figure S4. of Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Representative images showing the effects of RNAi targeting MCPIP1 on the changes in macrophage morphology induced by SiO2 treatment at 50 µg/cm2 for 24 h in U937 cells. SiO2 exposure led to morphologic changes in macrophages towards the M1 (arrow) and M2 phenotypes (arrowhead). However, knockdown of MCPIP1 significantly alleviated this effect of SiO2 treatment on macrophages (Figure S4). Scale bar = 200 µm

Additional file 1: Table S1. of Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Characterization of silica particles in the culture medium. Microscopic images of the dispersion state of silica particles in the culture medium in the presence of cells. Scale bar = 200 µm

Additional file 3: Figure S2. of Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Effect of SiO2 on MCPIP1 and p53 expression in U937 cells. Representative immunocytochemical images showing that SiO2 (50 µg/cm2) increased the expression of MCPIP1 and p53 in U937 cells at 24 h following SiO2 treatment. Scale bar = 20 μm

Additional file 8: Figure S7. of Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Effects of SiO2 on the levels of macrophage-derived cytokines. ELISAs suggested that the upregulated expression of MCP-1, TNF-α and TGF-β in macrophages induced by SiO2 treatment for 24 h was attenuated by pretreatment with 3-MA or Z-VAD-FMK. * p < 0.05 vs the corresponding control group; # p < 0.05 vs the corresponding SiO2 group