Structure Analysis for Tunnel Longitudinal Deformation Based on Segment Dislocation Mode

AbstractAccording to tunnel structure around joints, tunnel longitudinal deformation is analyzed and a three-dimensional finite element model is built based on segment dislocation mode. Tunnel structure stress analysis is conducted from two aspects of segment in the shear and bolt in the tension. The analysis results show: (1) Segment shear model. When segment dislocation reaches 0.03mm, the principal stressσ1 exceeds 3.0Mpa which is over concrete's tensile strength. Therefore, when convex tenon and concave tenon generate shear, there must be horizontal slipping and bolt is tensioned. (2) Bolt tension model. When joint opening value reaches 2mm, bolt stress exceeds 640Mpa, which is bolt's yield strength. When joint opening value reaches 6mm, which is the waterproof control standard for tunnel, bolt stress reaches 688.7Mpa, which is less than bolt's failure strength. The subway tunnel's structure safety should be controlled from the perspective of waterproof

Pore Pressure Response During 1986 Lotung Earthquakes

In 1986, two significant earthquake events in Lotung, Taiwan were recorded with both acceleration and pore water pressure traces at different depths below the ground surface. One event (M=6.2) was recorded on July 30th with an epcientral distance of 6km, and the other (M=7.0) was recorded on November 14th with an epicentral distance of about 80 km from the site. To analyze the recorded data, a finite element procedure was developed. The procedure incorporates a newly developed bounding surface hypoplasticity model for granular soils and can handle multidirectional input motions. The finite element procedure takes into consideration pore water pressure buildup and dissipation, pore water movement relative to the soil skeleton, compressibility of pore water, initial values of k0, overconsolidation ratios, and rotational shear effects. This paper describes the field project and presents the analytical results based on the above procedure which include the multidirectional shaking effects. The analytical results compare well with the field measurements

Bis(μ-2-{[2-(1,3-benzothia­zol-2-yl)hydrazinyl­idene]meth­yl}-6-meth­oxy­phenolato)bis­[dinitratodysprosium(III)] methanol disolvate

In the centrosymmetric dinuclear title compound, [Dy2(C15H12N3O2S)2(NO3)4]·2CH3OH, the two DyIII atoms are coordinated by two deprotonated 2-{[2-(1,3-benzothia­zol-2-yl)hydrazinyl­idene]meth­yl}-6-meth­oxy­phenol ligands and four nitrate ions, all of which are chelating. The crystal packing is stabilized by inter­molecular N—H⋯O hydrogen bonds and weak O—H⋯O inter­actions, forming a two-dimensional network parallel to (010)

Association of Short Tandem Repeat Polymorphism in the Promoter of Prostate Cancer Antigen 3 Gene with the Risk of Prostate Cancer

BACKGROUND: PCA3 (prostate cancer antigen 3) gene is one of the most prostate cancer-specific genes at present. Consequently, the prostate-specific expression and the sharp up-regulation of PCA3 mRNA in prostate cancer suggest a unique transcriptional regulation, which possibly can be attributed to promoter polymorphism. In our study, we evaluated whether there is polymorphism in PCA3 promoter region and also assess the association of the polymorphism with prostate cancer. METHODOLOGY/PRINCIPAL FINDINGS: We designed a specific primer set to screen the promoter of PCA3 gene by polymerase chain reaction (PCR)-based cloning and sequencing with the DNA extracted from peripheral blood samples of prostate cancer (PCa) cases (n = 186) and healthy control cases (n = 135). Genotype-specific risks were estimated as odds ratios (ORs) with associated 95% confidence intervals (CIs) by chi-square test. Possible deviation of the genotype frequencies from controls and PCa cases expected under Hardy-Weinberg equilibrium was assessed by the chi-square test. Short tandem repeat polymorphism of TAAA was found in the promoter region of PCA3 gene, five polymorphisms and eight genotypes were identified. The eight genotypes were divided into three groups: ≤10TAAA, 11TAAA, ≥12TAAA. The group 11TAAA and ≥12TAAA were associated with higher relative risk for prostate cancer than group ≤10TAAA (OR = 1.76, 95%CI = 1.07-2.89[for group 11TAAA]; OR = 5.28, 95%CI = 1.76-15.89[for group ≥12TAAA]). CONCLUSIONS/SIGNIFICANCE: The presence of the (TAAA)n short tandem repeat polymorphisms in the PCA3 promoter region may be a risk factor for prostate cancer in the Chinese population