Development and Testing of Monoclonal Antibodies-Based Diagnostic Preparation for <i>Bacillus anthracis</i> Spores Detection Using Latex Agglutination Method

Immobilization of anti-B. anthracis monoclonal antibodies (MAbs) on latex microparticles was studied, the optimal load of these MAbs was determined to be 20 µg for 50 µl of the stock latex suspension. The highest sensitivity of latex agglutination test was observed for 1E6 MAbs. Latex suspensions with immobilized MAbs were lyophilized. Their sensitivity and specificity were shown to be highly competitive with those of the stock liquid latex suspension. Latex diagnosticum for Bacillus anthracis spores detection was constructed on the basis of these lyophilized reagents, developed and approved was the regulatory documentation that included their application instructions and technical specifications. Carried out were inter-laboratory and commission tests of experimental prototypes of the designed latex diagnosticum. These preparations demonstrated high sensitivity (from 1·105 to 2·106 spores/ml and even more) and specificity (absence of cross-reactions with spores of different species of sporogenous bacilli at concentration of 108 spores/ml)

Measurement of the e+e−→K+K−π+π−e^+e^- \to K^+K^-\pi^+\pi^- cross section with the CMD-3 detector at the VEPP-2000 collider

The process $e^+e^- \to K^+K^-\pi^+\pi^-$ has been studied in the center-of-mass energy range from 1500 to 2000\,MeV using a data sample of 23 pb$^{-1}$ collected with the CMD-3 detector at the VEPP-2000 $e^+e^-$ collider. Using about 24000 selected events, the $e^+e^- \to K^+K^-\pi^+\pi^-$ cross section has been measured with a systematic uncertainty decreasing from 11.7\% at 1500-1600\,MeV to 6.1\% above 1800\,MeV. A preliminary study of $K^+K^-\pi^+\pi^-$ production dynamics has been performed

Study of the process e+e−→ppˉe^+e^-\to p\bar{p} in the c.m. energy range from threshold to 2 GeV with the CMD-3 detector

Using a data sample of 6.8 pb$^{-1}$ collected with the CMD-3 detector at the VEPP-2000 $e^+e^-$ collider we select about 2700 events of the $e^+e^- \to p\bar{p}$ process and measure its cross section at 12 energy ponts with about 6\% systematic uncertainty. From the angular distribution of produced nucleons we obtain the ratio $|G_{E}/G_{M}| = 1.49 \pm 0.23 \pm 0.30$

The development of path integration: combining estimations of distance and heading

Efficient daily navigation is underpinned by path integration, the mechanism by which we use self-movement information to update our position in space. This process is well-understood in adulthood, but there has been relatively little study of path integration in childhood, leading to an underrepresentation in accounts of navigational development. Previous research has shown that calculation of distance and heading both tend to be less accurate in children as they are in adults, although there have been no studies of the combined calculation of distance and heading that typifies naturalistic path integration. In the present study 5-year-olds and 7-year-olds took part in a triangle-completion task, where they were required to return to the startpoint of a multi-element path using only idiothetic information. Performance was compared to a sample of adult participants, who were found to be more accurate than children on measures of landing error, heading error, and distance error. 7-year-olds were significantly more accurate than 5-year-olds on measures of landing error and heading error, although the difference between groups was much smaller for distance error. All measures were reliably correlated with age, demonstrating a clear development of path integration abilities within the age range tested. Taken together, these data make a strong case for the inclusion of path integration within developmental models of spatial navigational processing

Obtainment of Monoclonal Antibodies and Prospects of Their Application as Basis for Immunodiagnostic Aids for Crimean-Congo Hemorrhagic Fever Virus Detection

) as framework for the production of tools for CCHF virus detection and identification in artificially contaminated samples and clinical specimens containing CCHF antigens was proven efficient

Measurement of the e+e−→π+π−e^+e^-\to\pi^+\pi^- cross section from threshold to 1.2 GeV with the CMD-3 detector

The cross section of the process $e^+e^-\to\pi^+\pi^-$ has been measured in the center of mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The measurement is based on a full dataset collected below 1 GeV during three data taking seasons, corresponding to an integrated luminosity of about 62 pb$^{-1}$. In the dominant $\rho$-resonance region, a systematic uncertainty of 0.7% has been reached. At energies around $\phi$-resonance the $\pi^+\pi^-$ production cross section was measured for the first time with high energy resolution. The forward-backward charge asymmetry in the $\pi^+\pi^-$ production has also been measured. It shows the strong deviation from the theoretical prediction based on conventional sQED framework and is in good agreement with GVDM and dispersive-based predictions. The impact of presented results on the evaluation of the hadronic contribution to the anomalous magnetic moment of muon is discussed.Comment: 52 pages, 36 figures; cosmetic changes of the text, fix fig.2 , fix comment on used selection cuts in the attached radiative correction tabl

Measurement of the pion formfactor with CMD-3 detector and its implication to the hadronic contribution to muon (g-2)

The cross section of the process $e^+e^-\to\pi^+\pi^-$ has been measured in the center of mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The measurement is based on an integrated luminosity of about 88 pb$^{-1}$ out of which 62 pb$^{-1}$ constitutes a full dataset collected by CMD-3 at center-of-mass energies below 1 GeV. In the dominant region near $\rho$-resonance a systematic uncertainty of 0.7% has been reached. The impact of presented results on the evaluation of the hadronic contribution to the anomalous magnetic moment of muon is discussed.Comment: 6 pages, 3 figure