Система обработки данных по оптическим и микрофизическим характеристикам аэродисперсной среды для оценки ослабления лучистой энергии

Разработана информационно-вычислительная система, реализующая численный эксперимент по определению ослабления и пропускания оптического излучения аэродисперсной средой. В качестве моделей отдельных рассеивателей рассмотрены столбики, пластинки, сферы, а также их агрегатов. В систему включаются архивы баз данных Aeronet и Hitran оптических и микрофизических характеристик кристаллических облаков. Программный комплекс ориентирован на обработку данных по ослаблению видимого и ИК излучения. Сравнительный анализ данных численного и натурного экспериментов показал возможность оценки физико-химических параметров среды

Multi-modal image segmentation based on machine learning methods

The purpose of this article is to introduce clustering algorithms and apply clustering methods to solve the problem of segmentation of medical images

Проектирование автоматизированной системы управления установки предварительного сбора воды

Объектом исследования является УПСВ. Цель работы – разработка автоматизированной системы управления УПСВ с использованием ПЛК, на основе выбранной SCADA-системы. В данном проекте была разработана система контроля и управления технологическим процессом на базе промышленных контроллеров Siemens SIMATIC S7-300 с применением SCADA-системы SIMATIC WinCC. Разработанная система может быть применена в системах контроля, управления и сбора данных на различных промышленных предприятиях.The object of the study is the UWWR. The aim of the work is the development of an automated control system for the UPSV using PLC, based on the selected SCADA system. In this project, a system for monitoring and controlling the process was developed on the basis of Siemens SIMATIC S7-300 industrial controllers using the SIMATIC WinCC SCADA system. The developed system can be applied in the systems of control, management and data collection at various industrial enterprises

Global Gene Expression Profiling and Transcription Factor Network Analysis of Cognitive Aging in Monozygotic Twins

Cognitive aging is one of the major problems worldwide, especially as people get older. This study aimed to perform global gene expression profiling of cognitive function to identify associated genes and pathways and a novel transcriptional regulatory network analysis to identify important regulons. We performed single transcript analysis on 400 monozygotic twins using an assumption-free generalized correlation coefficient (GCC), linear mixed-effect model (LME) and kinship model and identified six probes (one significant at the standard FDR < 0.05 while the other results were suggestive with 0.18 ≤ FDR ≤ 0.28). We combined the GCC and linear model results to cover diverse patterns of relationships, and meaningful and novel genes like APOBEC3G, H6PD, SLC45A1, GRIN3B, and PDE4D were detected. Our exploratory study showed the downregulation of all these genes with increasing cognitive function or vice versa except the SLC45A1 gene, which was upregulated with increasing cognitive function. Linear models found only H6PD and SLC45A1, the other genes were captured by GCC. Significant functional pathways (FDR < 3.95e-10) such as focal adhesion, ribosome, cysteine and methionine metabolism, Huntington's disease, eukaryotic translation elongation, nervous system development, influenza infection, metabolism of RNA, and cell cycle were identified. A total of five regulons (FDR< 1.3e-4) were enriched in a transcriptional regulatory analysis in which CTCF and REST were activated and SP3, SRF, and XBP1 were repressed regulons. The genome-wide transcription analysis using both assumption-free GCC and linear models identified important genes and biological pathways implicated in cognitive performance, cognitive aging, and neurological diseases. Also, the regulatory network analysis revealed significant activated and repressed regulons on cognitive function.Peer reviewe

DNA Methylation Profiles of GAD1 in Human Cerebral Organoids of Autism Indicate Disrupted Epigenetic Regulation during Early Development

DNA methylation profiling has become a promising approach towards identifying biomarkers of neuropsychiatric disorders including autism spectrum disorder (ASD). Epigenetic markers capture genetic risk factors and diverse exogenous and endogenous factors, including environmental risk factors and complex disease pathologies. We analysed the differential methylation profile of a regulatory region of the GAD1 gene using cerebral organoids generated from induced pluripotent stem cells (iPSCs) from adults with a diagnosis of ASD and from age- and gender-matched healthy individuals. Both groups showed high levels of methylation across the majority of CpG sites within the profiled GAD1 region of interest. The ASD group exhibited a higher number of unique DNA methylation patterns compared to controls and an increased CpG-wise variance. We detected six differentially methylated CpG sites in ASD, three of which reside within a methylation-dependent transcription factor binding site. In ASD, GAD1 is subject to differential methylation patterns that may not only influence its expression, but may also indicate variable epigenetic regulation among cells

Расчет энергетических параметров гидромеханического разрушения структуры нефтяных систем

A technique of determination of specific amount of mechanical energy necessary to destruct the supermolecular structure of paraffinic crude oils using the experimental rheological curves of laminar flow has been given. A cross-platform application capable of calculating the mechanical energy was designed as a result of this work

Aldehyde dehydrogenase 2 in sporadic Parkinson's disease

Aldehyde dehydrogenases (ALDH) play a key role in neuronal protection. They exert this function by metabolizing biogenic amine-related aldehydes, e.g. 3,4-dihydroxyphenylacetaldehyde (DOPAL), and by protecting neurons against aldehyde- and oxidative stress-related neurotoxicity. The role of these different isoenzymes has been discussed in other neurodegenerative disorders before. It is somewhat surprising that only few studies have investigated their role in the aetiology of Parkinson's disease (PD), in both the degeneration of dopaminergic neurons and the formation of Lewy bodies. Earlier studies report severe alterations of the cytosolic isoform of ALDH expression (ALDH 1A1) in the substantia nigra of patients with PD. However, there are no data regarding the activity of ALDH 2 located at the inner mitochondrial membrane. Since mitochondrial dysfunctions are hypothesized to be of importance in the aetiology of PD we have examined the enzymatic activity of mitochondrial ALDH 2 in post-mortem putamen and frontal cortex of patients with PD and controls. We found that mitochondrial ALDH 2 activity in contrast to the frontal cortex was significantly increased in the putamen of patients with PD compared to controls