Comparison of rubidium-82 positron emission tomography and thallium-201 SPECT imaging for detection of coronary artery disease

The diagnostic performance of rubidium-82 (Rb-82) positron emission tomography (PET) and thallium-201 (TI-201) single-photon emission-computed tomography (SPECT) for detecting coronary artery disease was investigated in 81 patients (52 men, 29 women). PET studies using 60 mCi of Rb-82 were performed at baseline and after intravenous infusion of 0.56 mg/kg dipyridamole in conjunction with handgrip stress. TI-201 SPECT was performed after dipyridamole-handgrip stress and, in a subset of patients, after treadmill exercise. Sensitivity, specificity and overall diagnostic accuracy were assessed using both visually and quantitatively interpreted coronary angiograms. The overall sensitivity, specificity and accuracy of PET for detection of coronary artery disease (>50% diameter stenosis) were 84,88 and 85%, respectively. In comparison, the performance of SPECT revealed a sensitivity of 84%, specificity of 53% (p < 0.05 vs PET) and accuracy of 79%. Similar results were obtained using either visual or quantitative angiographic criteria for severity of coronary artery disease. In 43 patients without prior myocardial infarction, the sensitivity for detection of disease was 71 and 73%, respectively, similar for both PET and SPECT. There was no significant difference in diagnostic performance between imaging modalities when 2 different modes of stress (exercise treadmill vs intravenous dipyridamole plus handgrip) were used with SPECT imaging. Thus, Rb-82 PET provides improved specificity compared with TI-201 SPECT for identifying coronary artery disease, most likely due to the higher photon energy of Rb-82 and attenuation correction provided by PET. However, post-test referral cannot be entirely excluded as a potential explanation for the lower specificity of TI-201 SPECT.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29280/1/0000339.pd

Comparison of thallium-201 SPECT redistribution patterns and rubidium-82 PET rest-stress myocardial blood flow imaging

To compare regional thallium-201 SPECT redistribution patterns with rubidium-82 PET, we studied 81 patients with both imaging modalities. Sixty patients had significant coronary artery disease. All patients underwent PET imaging after dipyridamole infusion, while SPECT imaging was performed after exercise stress (38 patients) and dipyridamole (43 patients). Sixty-eight percent of patients with prior infarct had fixed defects on SPECT, compared to 39% with PET. Sixty-one percent of patients with prior infarct had PET perfusion defects which exhibited ‘reflow’ or normal rubidium-82 tracer uptake (p < 0.05 vs. SPECT). Similar results were seen in patients without prior infarct (26% fixed defects on SPECT vs. 12% for PET, p < 0.05). Regional analysis showed that 57% of fixed SPECT defects corresponded to PET defects with reflow or normal rubidium-82 uptake, while 78% of ‘fixed’ PET defects corresponded to fixed SPECT defects. PET reflow and normal rubidium-82 uptake in sites of fixed thallium-201 SPECT perfusion defects suggest that imaging modalities employing separate tracer injections at rest and after stress, such as rubidium-82 PET, may be more specific in the assessment of myocardial viability, especially in patients with prior myocardial infarction.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42537/1/10554_2005_Article_BF01151577.pd

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Acn&eacute; juvenil, presentaci&oacute;n de 2 casos cl&iacute;nicosAlta ingesta de prote&iacute;nas y su relaci&oacute;n con el aumento de tejido adiposo en preescolaresAn&aacute;lisis para la integraci&oacute;n entre salud y educaci&oacute;n para el desarrollo de programas de promoci&oacute;nCalidad de los estilos de vida de funcionarios acad&eacute;micos de la Universidad del Biob&iacute;oCambios en el patr&oacute;n de consumo de alimentos en ni&ntilde;os con un kiosco saludableCaracter&iacute;sticas del sue&ntilde;o habitual y su relaci&oacute;n con el nivel de somnolencia diurna en adolescentesCaracterizaci&oacute;n de informaci&oacute;n acerca de promoci&oacute;n de salud poblaci&oacute;n urbana de Temuco, Regi&oacute;n de la Araucan&iacute;a, ChileComportamiento sexual durante el embarazo en usuarias de centros de salud, La Florida, Santiago, 2006Estado nutricional y actividad f&iacute;sica en escolares de 1&ordm;, 5&ordm; y 8&ordm; b&aacute;sico de Arica&iquest;Est&aacute;n los padres informados si sus hijos tienen miedo a la atenci&oacute;n dental?Evaluaci&oacute;n cualitativa del componente promocional de un programa psicosocial en poblaci&oacute;n escolar vulnerableEvaluaci&oacute;n de la efectividad de la aplicaci&oacute;n del Programa Educativo "Quiero mi boca siempre sana"Evaluaci&oacute;n estad&iacute;stica del uso de edulcorantes alimentarios en una poblaci&oacute;n de SantiagoEvoluci&oacute;n de la prematurez y caracter&iacute;sticas sociodemogr&aacute;ficas de la poblaci&oacute;n materna en ChileFactores de riesgo asociados a prevalencia de caries en alumnos del Ej&eacute;rcito de ChileH&aacute;bitos alimentarios en escolares de distinto tipo de establecimientos educacionalesNivel de conocimientos de los habitantes de Loncoche sobre enfermedades parasitarias, IX, Regi&oacute;n, Chile 2009Nutrici&oacute;n y condiciones socioecon&oacute;micas de escolares de la escuela Jes&uacute;s Mar&iacute;a Sifontes, Los Teques, VenezuelaRelaci&oacute;n entre dificultad para comprar cigarrillos, lugares de venta y curso en adolescente