Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon

1,2,4-Triazoles and 1,3,4-oxadiazoles independently are very important pharmacophores. In view of this, a new class of 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs have been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Molecular docking of all the title compounds into S. aureus tyrosyl-tRNA synthetase (PDB: 1JIJ) and lanosterol 14α-demethylase complex with standard inhibitor Fluconazole (PDB: 3KHM) was performed which snugly fitted into the active site thus explaining their excellent inhibitory activity exhibiting their possible antibacterial and antifungal activity, respectively. Drug-likeliness, Drug score values and toxicity prediction analyses of all the title compounds have shown favourable values and these molecules belong to Class 4 and Class 5 categories which make them useful scaffolds. Interestingly, the compounds 7h, 7i, 7k, 7u and 7v have exhibited majestic antibacterial activity. Also, these compounds have shown antifungal activity against all pathogenic fungal strains with lower MIC value ranging from 0.50 - 4.00 µg/mL

Synthesis of 3-aryl-4-({2-[4-(6-substituted-coumarin-3-yl)-1,3-thiazol-2-yl]hydrazinylidene}methyl/ethyl)-sydnones using silica sulfuric acid and their antidiabetic, DNA cleavage activity

A novel one-pot synthesis of sydnones appended to coumarins (4a–r) via thiazole in presence of silica sulfuric acid as a heterogeneous catalyst is discussed. The use of low cost and reusable silica sulfuric acid as catalyst makes this process feasible and convenient. Further, the title compounds were screened for their α-amylase inhibition (antidiabetic) as well as DNA cleavage activities

Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon

1082-10961,2,4-Triazoles and 1,3,4-oxadiazoles independently are very important pharmacophores. In view of this, a new class of 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs have been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Molecular docking of all the title compounds into S. aureus tyrosyl-tRNA synthetase (PDB: 1JIJ) and lanosterol 14α-demethylase complex with standard inhibitor Fluconazole (PDB: 3KHM) is performed which snugly fitted into the active site thus explaining their excellent inhibitory activity exhibiting their possible antibacterial and antifungal activity, respectively. Drug-likeliness, Drug score values and toxicity prediction analyses of all the title compounds have shown favourable values and these molecules belong to Class 4 and Class 5 categories which make them useful scaffolds. Interestingly, the compounds 7h, 7i, 7k, 7u and 7v have exhibited majestic antibacterial activity. Also, these compounds have shown antifungal activity against all pathogenic fungal strains with lower MIC value ranging from 0.50 - 4.00 μg/mL