Normalized brain structure volumes.

<p>Results with <i>p</i><0.01 are shown in bold face. <i>Abbreviations</i>. <i>HV</i>, healthy volunteers. <i>MS</i>, multiple sclerosis. <i>SD</i>, standard deviation.</p

Cohort demographic data.

a<p> <i>median (range),</i></p>b<p> <i>mean z-score (standard deviation),</i></p>c<p> <i>median (interquartile range).</i></p>*<p>Vibration units are amplitudes, proportional to the square of the applied voltage.</p><p><i>Abbreviations</i>. <i>RRMS</i>, relapsing remitting multiple sclerosis. <i>SPMS</i>, secondary progressive multiple sclerosis. <i>PPMS</i>, primary progressive multiple sclerosis. <i>CIS</i>, clinically isolated syndrome. <i>EDSS</i>, Expanded Disability Status Scale. <i>MSSS</i>, Multiple Sclerosis Severity Score. <i>MSFC</i>, Multiple Sclerosis Functional Composite. <i>PASAT-3</i>, Paced Auditory Serial-Addition Task, 3 second version.</p

Partial correlations of impairment measures with normalized structure volumes.

<p>Results are adjusted for linear effects of age and sex. The <i>p</i>-values are shown in parentheses, and results with <i>p</i><0.01 are shown in boldface. <i>Abbreviations</i>. <i>EDSS</i>, Expanded Disability Status Scale. <i>MSSS</i>, MS Severity Score. <i>MSFC</i>, Multiple Sclerosis Functional Composite <i>z</i>-score. <i>PASAT-3</i>, Paced Auditory Serial Addition Test, 3-second version.</p

Partial correlations of impairment measures with normalized structure volumes computed by FSL FAST segmentation tool.

<p>Results are adjusted for linear effects of age and sex. The <i>p</i>-values are shown in parentheses, and results with <i>p</i><0.01 are shown in boldface. <i>Abbreviations</i>. <i>EDSS</i>, Expanded Disability Status Scale. <i>MSSS</i>, MS Severity Score. <i>MSFC</i>, Multiple Sclerosis Functional Composite. <i>PASAT-3</i>, Paced Auditory Serial Addition Test, 3-second version.</p

Partial correlations of normalized brain structure with one another in MS cases.

<p>Results are adjusted for linear effects of age and sex. The <i>p</i>-values are shown in parentheses, and results with <i>p</i><0.01 are shown in boldface.</p

Lesion-TOADS segmentation results.

<p>Representative slices from the T1-weighted (A) and FLAIR (B) scans of one of the MS cases. Lesions are depicted in red (C). 3D rendering of ventricles (blue), putamen (green), caudate (orange), thalamus (pink), brainstem (yellow), and lesions (red), generated by Lesion-TOADS (D).</p

Figure 2

<p>Distributions of normalized cortical gray matter (A) and cerebral white matter (B) volumes in healthy volunteers vs. MS cases. White matter volume is not significantly atrophic in the MS group, whereas cortical GM volume is substantially lower in MS.</p

Boxplots of interscanner agreement for measures of RNFL thickness and TMV between Stratus OCT and Cirrus HD-OCT and Spectralis OCT and Cirrus HD-OCT.

<p>Boxplots illustrating the inter-quartile range for interscanner agreement indices show stronger agreement between Cirrus HD-OCT and Spectralis OCT measurements than between Cirrus HD-OCT and Stratus OCT. The lower and upper boundaries of each rectangle represent the 25^th and 75^th percentiles respectively, while the horizontal lines in between these represent the 50^th percentile.</p

Correlation between RNFL thickness and TMV measures between Stratus OCT and Cirrus HD-OCT.

<p>Scatter plot of average RNFL thickness (1a) and TMV (1b) measured by Stratus OCT plotted against average RNFL thickness and TMV measured by Cirrus HD-OCT (n = 229). There was a strong linear agreement between Cirrus HD-OCT and Stratus OCT measurements of RNFL thickness (solid line) (r = 0.93; p<0.001) and TMV (solid line) (r = 0.95; p<0.001). The line of equality (dotted line) demonstrates Cirrus HD-OCT measurements of RNFL thickness are generally lower than with Stratus OCT, and Cirrus HD-OCT measurements of TMV are consistently greater than with Stratus OCT.</p

Retinal Nerve Fiber Layer Thicknesses and Total Macular Volume Among Cirrus HD-OCT vs. Stratus Study Participants.

<p>Abbreviations: OCT: Optical coherence tomography; RNFL: Retinal nerve fiber layer; RRMS: Relapsing remitting multiple sclerosis; MS: Multiple sclerosis; TMV: Total macular volume; CI: confidence interval; LOA: limit of agreement.</p><p>*All measurements are in µm.</p><p>**All measurements are in mm³.</p