Physiological studies on the effects of hormonal imbalance on the CNS

The levels of cholesterol in the fore, mid and hind brain regions were determined in normal and Pars distalis ablatedRana cyanophlictis, at various time intervals after the operation. The time course of the effects of removal of Pars distalis showed an initial overshoot (shock effect) and a recovery phase leading to a new stabilized stage. In general ablation of Pars distalis resulted in the elevation of the levels of cholesterol during the first week after the operation (P>0·05, 0·001 and 0·001 for the fore, mid and hind brain on the first day after the operation). Regional differences in the magnitude of response were significant. A possible relationship between adrenal steroids and thyroid hormones and cholesterol synthesis is suggested

Physiological studies on the effects of hormonal imbalance on the CNS: 2. Time course of the effects of extirpation of pars distalis on the levels of cholesterol in the brain of the frog, Rana cyanophlictis

Extirpation of the pituitary pars distalis of R. cyanophlictis caused an increase in cholesterol level (shock effect) in the fore-​, mid-​, and hindbrain over the next 5 days compared to that in sham-​operated controls. Recovery occurred subsequently. The increase in cholesterol level was greatest in the forebrain 15 min after ablation and was greatest in the hindbrain 1 day after ablation. The hormonal imbalance caused by removal of the pars distalis was probably responsible for the changes in brain cholesterol metab

Hyperglycemia and liver glycogenolysis in histamine administered frogs

Histamine acid phosphate [51-​74-​1] (0.01 mg, i.m.) administration in frogs caused hyperglycemia, a decrease in the liver glycogen [9005-​79-​2] content, and an increase in the rate of glucose [50-​99-​7] absorption in isolated intestinal segments. Thus, besides acting as a local hormone, histamine also affects carbohydrate metab