Тhe prevalence of metabolically healthy obesity: data from the epidemiological survey in of Novosibirsk

Background: Obesity is associated with numerous metabolic complications, such as type 2 diabetes mellitus (DM2), dyslipidemia, arterial hypertension (AH), cardiovascular diseases and some forms of cancer. Nevertheless, the literature describes a group of obese individuals who are more resistant to the development of metabolic disorders. At present, this phenomenon is known as "Metabolically healthy obesity", "metabolically healthy obesity" (MZO). Despite the presence of excess weight or obesity, a favorable metabolic profile can be observed in this cohort of patients, characterized by preserved insulin sensitivity, absence of arterial hypertension, normal lipid, hormonal profile, absence of inflammation and unchanged hepatic transaminases. Aims: To study the prevalence of metabolically healthy obesity (MHO) and its characteristics in men and women at the age of 45–69 years in Novosibirsk. Materials and methods: To study covered 3197 persons from the base of the international project HAPPIE. They had a body mass index (BMI ≥ 30 kg/m²). «Metabolically healthy obesity» was determined as obesity (BMI ≥ 30 kg/m², with 2 and fewer components of metabolic syndrome (MS) by criteria NCEP ATP III, 2001. Statistical analisys SPSS-13. Results: The prevalence of metabolic healthy obesity (MHO) was 42% (38% for men and 43% for women). The examined people with MHO have reliably more favorable average level of TG, HDL-cholesterol, indicators of blood glucose, systolic arterial pressure and diastolic arterial pressure and less waist circumference. In the groups withMHO and MS abdominal obesity is common in men at 95 and 71%, in women at 99 and 90%; hyperTG – in men at 74 and 9%, in women at 72 and 5,5%; lower level HDL-cholesterol in 16 and 1% for men, and in 44,5% and 3% for women; AP in 96 and 77% and 94 and 71% in men and women respectively, the frequency fasting of hyperglycaemia 77 and 21% in men and 60 and 5% in women was markedly different. According to the data obtained by us, the frequency in the sample is high and amounted to 42%. In the subgroup the most commonly found is the MHO phenotype – 53%, than in the men -38%, р <0,001 Conclusions: According to our data, the frequency of metabolic healthy obesity in the sample is high and amounted to 42%. In the female subgroup, a metabolically healthy phenotype is more common 43% than in the male 38%, p <0.001. Metabolically healthy obese individuals are characterized by a significantly lower incidence of fasting hyperglycaemia and dyslipidemia

Internet technologies in modern concept of English teaching (general and translation theory)

The problems of teaching a foreign language to students of non-linguistic higher educational institutions have changed radically. Besides the professional qualification, an expert has to possess the skills of free language proficiency as the means of business communication within the professional activity. Relevance of new information technologies’ use is dictated by the pedagogical needs for increasing the efficiency of the training developing, in particular, the need of the following skills’ formation: independent educational activity, research, creative approach for training, formations of critical thinking, new culture. The new information technologies in teaching a foreign language use is caused not only by aspiration to novelty, but by training at the info communication technologies base, which allows to realize a personally focused approach to the identity a student as the main conceptual direction of the 21st century formation

Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population

Aim. To study the associations of risk factors for chronic non-communicable diseases (CNCDs) and osteoporotic fractures (OFs) in a population sampling over 50 years. Materials and Methods. The data of a cross-sectional population-based study obtained in the Russian part of the international project HAPIEE (Novosibirsk) are analyzed. The present analysis comprised 7363 men and women aged 50–69 years old. We have assessed the frequency of OFs for the last 12 months and risk factors of CNCDs. Cross-sectional associations between OF history and potential determinants were analyzed using multivariable-adjusted logistic regression. Results. The frequency of OFs in the last 12 months was 3.6% (3.2% in men and 4.0% in women, p = 0.074). In men, the probability of OFs increased with an elevation of blood pressure (BP), high-density lipoprotein cholesterol (HDL-C), ethanol consumption, and reduced with increased body mass index (BMI). In women, the probability of a fracture increased with current smoking and an increased duration of post-menopause and reduced with an increase in triglycerides (TG) levels, independently of other factors. Conclusions. A syndemia of risk factors, both generally recognized for OFs (BMI, tobacco smoking, alcohol consumption, postmenopausal duration) and new factors associated with CNCDs (BP, HDL, TG), have been defined

The epidemiology of obesity and the development of disorders of glucose metabolism according to a prospective study in Siberia

Introduction: Persons who are overweight and obese have a higher risk of development of diabetes mellitus. In Russia, the epidemiological trends of glucose metabolism disorders in obese persons are understudied.Aim. To study the prevalence of overweight and obesity in a population sample aged 45–69 (Novosibirsk), and to assess the relationship between body mass index and 3-year dynamics of glucose metabolism disorders in a prospective cohort study.Material and Methods: A representative population sample of men and women 45–69 years old was examined in Novosibirsk in 2003–2005 (baseline survey, HAPIEE Project). In a prospective study 2,787 individuals without baseline diabetes who participated in the first and repeated surveys (2006–2008) were analyzed. The average duration of prospective follow–up comprised 3±0.01 years. Anthropometric measurements, biochemical assessment including lipids and carbohydrate metabolism were performed. Diabetes mellitus was defined by epidemiological criteria in patients with established diabetes history and in individuals with fasting blood glucose level ≥7,0mmol/l (WHO, 1999). The classification of obesity by BMI value was used according to WHO (1997).Results: In a population sample aged 45–69 in 2002–2006 the proportions of persons with BMI value ≥25 and <30kg/m2 was 37.5%, and with BMI≥30kg/m2 – 35%. Among persons with baseline overweight, the rate of new diabetes cases was 2.5 times higher than among those with normal body weight. In persons with baseline obesity the rate of new diabetes cases was 6 times higher than in those with normal body weight. Men with BMI ≥25 and <30 kg/m2 had a frequency of new diabetes 3.4 times higher, and in persons with BMI≥30 kg/m2 – 8.5 times higher than in men with normal BMI. Women with excess body weight had a rate of newly emerged diabetes mellitus 1.7 times higher, and women with obesity – 6 times higher than in a group with normal body weight.Conclusion: The prevalence of obesity in a Siberian population aged 45–69 years comprises 35%. In studied population sample, person with excess body weight have a 3-year incidence of new-onset diabetes 2.5 times higher compared to those with normal body weight. In obese persons the frequency of new diabetes was 6 times higher compared to those with BMI ≤25 kg/m2. Among persons with obesity, the frequency of new diabetes is 2 times higher in men than in wome

Validation of the Finnish diabetes risk score (FINDRISC) for the Caucasian population of Siberia

Aim. A validation of the Finnish diabetes risk score (FINDRISC) was conducted among the Siberian population. FINDRISC was used to study the prevalence of risk factors for type 2 diabetes mellitus (T2DM) and to estimate the incidence of T2DM in high-risk groups during a 10-year observation period.  Materials and methods. A total of 9,360 subjects aged between 45 and 69 years were enrolled in this cross-sectional, population-based study. FINDRISC was used to group 8,050 people without diabetes according to their risk for T2DM. Statistical analysis was performed using SPSS.  Results. When a cutoff point of 11 was used to identify those with diabetes, sensitivity was 76. 0% and specificity was 60. 2%. The area under the receiver operating curve for diabetes was 0. 73 (0. 73 for men and 0. 70 for women). More than one-third (31. 7%) of the adult population of Novosibirsk was estimated to have medium, high or very high risk of developing T2DM in the next 10 years. Cases of T2DM estimated to occur during the 10 years of follow-up had significantly higher incidence of risk factors such as BMI ≥30 kg/m2, waist circumference 102 cm in men and 88 cm in women and a family history of T2DM and were more likely to take drugs to lower blood pressure.  Conclusion. FINDRISC provided good results in our sample, and we recommend its use in the Siberian population

Analysis of the actual nutrition of the female population of Novosibirsk, depending on the magnitude of the glycemic index of their diet

Background. When choosing foods rich in carbohydrates, it is important to consider not only their chemical composition, but also the ability to influence the level of postprandial blood glucose (glycemic response). A qualitative indicator of this ability is the glycemic index (GI) of a carbohydrate-containing product. Recently, there have been some evidences that control of GI nutrition can be important for prevention and nutrition therapy of metabolic disorders. Aim. To determine of the magnitude of the glycemic index (GI) of actual nutrition in women in Novosibirsk, and the study of the connection with metabolism and obesity. Material and methods. The study was designed as cross-sectional research and was carried out within the framework of the international HAPIEE project on a random representative sample of the unorganized population of Novosibirsk, 4397 women, the average age was 57.7 ± 7.1, without diabetes. For the calculation of GI nutrition, the International Table of Glycemic Index and Glycemic Load (2008) were used. The frequency method was used to evaluate the actual nutrition. Metabolic Syndrome (MS) criteria were used in accordance with the Russian National Recommendations of the GEF (2009), as well as with the international recommendations of NCEP ATP III (2001) and JIS (2009). Statistical processing of data was carried out using the SPSS 13.0 software package (Bonferroni criterion in the GLM procedure). The odds ratio (OR) was estimated using binary logistic regression in quartiles of the glycemic index. Differences were considered statistically significant at p <0.05. Results. The GI of women's nutrition was on average low and amounted to 53.1 units. In the quartiles of the GI OR, the MS for all the criteria used was not significantly different. In the quartiles of the body mass index (BMI) in women with GI in the group with normal body weight (BMI = 23.3 kg/m2) was significantly higher by 0.9 units (p <0.001) compared with the obese group (BMI = 37.3 kg/m2). The diet was unbalanced and did not meet the recommendation in all groups of women studied. It was noted a significant reduction in the group with obesity 1.6 times the value of total caloric intake per 1 kg of body weight. Conclusions. Nutrition of women in Novosibirsk is unbalanced, with increased consumption of fat and inadequate intake of carbohydrates. The GI value is close to the GI nutrition of the population of European countries. The presence of a connection between the GI nutrition of women with a metabolic disorder in the sample of the population was not established

Chapter 8. Transformation of value orientations in the economic sphere of society

Процеси які унаслідувало українське суспільство 24 серпня 1991 року, а головною особливістю економічної сфери його інституційної матриці стало формування олігархічних утворень, що спричинило поєднання самих негативних компонент, властивих, як радянській економіці, так і західній. Ця обставина призвела до процесу ще більшої девальвації духовної компоненти, як в моралі молодого покоління, так і суспільства в цілому, що у свою чергу, дозволило правлячій еліті почати інтеграцію матеріальних ціннісних орієнтацій у свідомість молоді. Тому цілком закономірно, що в сучасному українському суспільстві в свідомості молодого покоління домінуючими є не духовні, а матеріальні ціннісні орієнтації

Triglycerides, Obesity and Education Status Are Associated with the Risk of Developing Type 2 Diabetes in Young Adults, Cohort Study

Background: It is important to determine the influence of traditional risk factors on the development of type 2 diabetes mellitus (T2DM) in young adults. Goal of the research: To study the incidence of T2DM and factors that increase the risk of its occurrence during the observation of a cohort of young adults. Materials and methods: 1341 people aged 25–44 were included in the study from 2013 to 2017, of whom 622 were men (46.4%). The examination included anamnesis, anthropometric data, and a blood test. Cases of developed T2DM were identified by comparing the Diabetes Mellitus Register, medical records of patients, and the database of examined individuals from 2019 to 2023. T2DM Results: In the examined population, 11 participants (0.82%) developed T2DM. The prevalence of T2DM was 0.96% in men and 0.69% in women. Patients with T2DM had a higher waist circumference, BMI, SBP, TG, and lower HDL than patients without T2DM, and were also less likely to have a higher education. The risk of developing T2DM increases 6.5 times at a BMI of ≥30 kg/m2, and 5.2 times at a TG level of ≥1.7 mmol/L, regardless of other risk factors. In the absence of a higher education, the risk of developing T2DM is increased by 5.6 times. Conclusion: In young people, high triglyceride levels, obesity, and a low level of education are associated with the risk of developing type 2 diabetes, regardless of other factors