A. Body weight during the treatment.

<p>B. Body weight change (% of the beginning body weight) during the treatment. One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.</p

mRNA levels of several genes in epididymal fat and liver at the end of the study.

<p>Values shown are mean ± se. Student t- test, compared to DIO Veh, *p<0.05.</p

Plasma creatinine, BUN, lipase, ALT and AST levels at the end of treatment.

<p>Values shown are mean ± se. One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.</p

Liver, spleen and epididymal fat weights, liver TG and plasma total PAI-1 at the end of treatment.

<p>Values shown are mean ± se. One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.</p

Fat mass change before and after 10-week treatment.

<p>One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.</p

Oral glucose tolerance test (A and B).

<p>On Day 64, overnight fasted mice were challenged with oral glucose dosing at 2 g/kg. Blood glucose was measured at 0, 30, 60 and 120 minute after glucose dosing. Glucose area under curve was also calculated. C. Fed blood glucose was measured on day 1 and day 54. Student t-test vs the vehicle group, *, P<0.05.</p