4 research outputs found
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 1. Process Development for Scale-up of 2,5,8-Substituted 5,11-Dihydrochromeno[4,3- c
No full textAn Efficient Synthesis of 3‑Substituted <i>N</i>‑Glycoside Indoles Useful as Sodium-Dependent Glucose Transporter Inhibitors
No full textA practical synthesis of two <i>N</i>-glycoside
indoles <b>1</b> and <b>2</b>, identified as highly potent
sodium-dependent
glucose transporter (SGLT) inhibitors is described. Highlights of
the synthetic process include a selective and quantitative Vilsmeier
acylation and a high-yielding Grignard coupling reaction. The chemistry
developed has been applied to prepare two separate SGLT inhibitors <b>1</b> and <b>2</b> for clinical evaluation without recourse
to chromatography
bedlamer
No full textbedlamer'kind of seal' - Sealing term.'kind of seal' - Sealing term.PRINTED ITEMG. M. Story MAY 1970JH MAY 1970Used I and SupUsed I and Sup1Not use
