28,918 research outputs found
Electrochemical characterization of systems for secondary battery application Second quarterly report, Aug. - Oct. 1966
Multisweep cyclic voltammetry for electrochemical characterization of systems for secondary battery applicatio
A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing primary total hip arthroplasty under spinal anaesthesia with levobupivacaine. One hundred and eight patients were randomly allocated to receive either ultrasound-guided fascia iliaca block with 2 mg.kg−1 levobupivacaine (fascia iliaca group) or spinal morphine 100 μg plus a sham ultrasound-guided fascia iliaca block using saline (spinal morphine group). The pre-defined non-inferiority margin was a median difference between the groups of 10 mg in cumulative intravenous morphine use in the first 24 h postoperatively. Patients in the fascia iliaca group received 25 mg more intravenous morphine than patients in the spinal morphine group (95% CI 9.0–30.5 mg, p < 0.001). Ultrasound-guided fascia iliaca block was significantly worse than spinal morphine in the provision of analgesia in the first 24 h after total hip arthroplasty. No increase in side-effects was noted in the spinal morphine group but the study was not powered to investigate all secondary outcomes
Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in osteoclasts remain unknown. This investigation used the P2Y2 receptor knockout (P2Y2R−/−) mouse model to investigate the role of this receptor in bone. MicroCT analysis of P2Y2R−/− mice demonstrated age-related increases in trabecular bone volume (≤48%), number (≤30%) and thickness (≤17%). In vitro P2Y2R−/− osteoblasts displayed a 3-fold increase in bone formation and alkaline phosphatase activity, whilst P2Y2R−/− osteoclasts exhibited a 65% reduction in resorptive activity. Serum cross-linked C-telopeptide levels (CTX, resorption marker) were also decreased (≤35%). The resorption defect in P2Y2R−/− osteoclasts was rescued by the addition of exogenous ATP, suggesting that an ATP deficit could be a key factor in the reduced function of these cells. In agreement, we found that basal ATP release was reduced up to 53% in P2Y2R−/− osteoclasts. The P2Y2 receptor agonists, UTP and 2-thioUTP, increased osteoclast activity and ATP release in wild-type but not in P2Y2R−/− cells. This indicates that the P2Y2 receptor may regulate osteoclast function indirectly by promoting ATP release. UTP and 2-thioUTP also stimulate ATP release from osteoblasts suggesting that the P2Y2 receptor exerts a similar function in these cells. Taken together, our findings are consistent with the notion that the primary action of P2Y2 receptor signalling in bone is to regulate extracellular ATP levels
Behavior of the Dripping Faucet over a Wide Range of the Flow Rate
The time interval of successive water-drips from a faucet was examined over a
wide range of the flow rate. The dripping interval alternately exhibits a
stable state and a chaotic state as the flow rate increases. In the stable
state, the volume of the drip is kept constant at fixed flow rates, and the
constant volume increases with the flow rate. In the chaotic state, in addition
to a mechanics that the drip is torn by its own weight, the vibration of the
drip on the faucet takes part in the strange behavior of the interval.Comment: 7 pages, 7 figures, to be published in J. Phys. Soc. Jpn vol
68-2(1999
Liquid drop splashing on smooth, rough and textured surfaces
Splashing occurs when a liquid drop hits a dry solid surface at high
velocity. This paper reports experimental studies of how the splash depends on
the roughness and the texture of the surfaces as well as the viscosity of the
liquid. For smooth surfaces, there is a "corona" splash caused by the presence
of air surrounding the drop. There are several regimes that occur as the
velocity and liquid viscosity are varied. There is also a "prompt" splash that
depends on the roughness and texture of the surfaces. A measurement of the size
distribution of the ejected droplets is sensitive to the surface roughness. For
a textured surface in which pillars are arranged in a square lattice,
experiment shows that the splashing has a four-fold symmetry. The splash occurs
predominantly along the diagonal directions. In this geometry, two factors
affect splashing the most: the pillar height and spacing between pillars.Comment: 9 pages, 11 figure
Dynamics of Inner Galactic Disks: The Striking Case of M100
We investigate gas dynamics in the presence of a double inner Lindblad
resonance within a barred disk galaxy. Using an example of a prominent spiral,
M100, we reproduce the basic central morphology, including four dominant
regions of star formation corresponding to the compression maxima in the gas.
These active star forming sites delineate an inner boundary (so-called nuclear
ring) of a rather broad oval detected in the near infrared. We find that
inclusion of self-gravitational effects in the gas is necessary in order to
understand its behavior in the vicinity of the resonances and its subsequent
evolution. The self-gravity of the gas is also crucial to estimate the effect
of a massive nuclear ring on periodic orbits in the stellar bar.Comment: 11 pages, postscript, compressed, uuencoded. Paper and 4 figures
available at ftp://pa.uky.edu/shlosman/nobel or at
http://www.pa.uky.edu/~shlosman/ . Invited talk at the Centennial Nobel
Symposium on "Barred Galaxies and Circumnuclear Activity," A.Sandquist et al.
(Eds.), Springer-Verlag, in pres
The Case for an Accelerating Universe from Supernovae
The unexpected faintness of high-redshift Type Ia supernovae (SNe Ia), as
measured by two teams, has been interpreted as evidence that the expansion of
the Universe is accelerating. We review the current challenges to this
interpretation and seek to answer whether the cosmological implications are
compelling. We discuss future observations of SNe Ia which could offer
extraordinary evidence to test acceleration.Comment: To appear as an Invited Review for PASP 20 pages, 13 figure
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