Capturing the scale and pattern of recurrent care proceedings: initial observations from a feasibility study

This article reports the initial findings of a feasibility study that has captured the scale and pattern of recurrent care proceedings. Although frontline professionals have reported long-standing concerns about the repeat clients of public law proceedings, prior to the study we report, the scale of the problem has been unknown. With funding from the Nuffield Foundation and support from the Child and Family Court Advisory Service (CAFCASS) and the President of the Family Division, the research team has arrived at a first estimate of prevalence, confirming that recurrence is a sizeable problem for the English family court. Based on cases that completed during the observational window 2007-2013 (calendar years), 7,143 birth mothers appeared in 15,645 recurrent care applications concerning 22,790 infants and children. Moreover, the study most likely underestimates recurrence, because reliable data concerning completed cases is not available before 2007. Initial observations are that the spacing between recurrent care proceedings is very short, which raises searching questions about prevention. Where episodes of care proceedings follow in swift succession, most likely prompted by the birth of another infant, this affords mothers little opportunity to effect change. Unless, this ‘status quo’ is tackled, it is difficult to envisage how vulnerable birth mothers can exit this cycle. Preliminary recommendations are made in respect of policy and practice change

Contrasts between Equilibrium and Non-equilibrium Steady States: Computer Aided Discoveries in Simple Lattice Gases

A century ago, the foundations of equilibrium statistical mechanics were laid. For a system in equilibrium with a thermal bath, much is understood through the Boltzmann factor, exp{-H[C]/kT}, for the probability of finding the system in any microscopic configuration C. In contrast, apart from some special cases, little is known about the corresponding probabilities, if the same system is in contact with more than one reservoir of energy, so that, even in stationary states, there is a constant energy flux through our system. These non-equilibrium steady states display many surprising properties. In particular, even the simplest generalization of the Ising model offers a wealth of unexpected phenomena. Mostly discovered through Monte Carlo simulations, some of the novel properties are understood while many remain unexplained. A brief review and some recent results will be presented, highlighting the sharp contrasts between the equilibrium Ising system and this non-equilibrium counterpart.Comment: 9 pages, 3 figure

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab

Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition. Case presentation: We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital. Conclusion: Rituximab, the efficacy of which has thus far been examined predominantly in patients outside the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease can benefit from intensive care

Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila

Sleep is plastic and is influenced by ecological factors and environmental changes. The mechanisms underlying sleep plasticity are not well understood. We show that manipulations that impair flight i

Leadership development in a faith-based non-profit organisation using a relational leadership model: A case study

This paper describes a case study of a Leadership Development Program (LDP) which has been developed and conducted at a large faith-based non-profit organization providing aged and community care in Australia. Walter Wright's Relational Leadership model which used insights from Jude, Philemon and Colossians was adopted by the organization. Started as a pilot in 2003 the LDP was implemented in 2007 and has been run regularly since then. The LDP was systematically evaluated by an independent researcher recently. The evaluation concluded that the program has been effective and recommended that it continue with some minor modifications. The organization in which this program was developed is a partner in an Australian Research Council (ARC) linkage grant started in 2010 between three universities and two faith-based non-profit organizations providing aged care and community care. This paper has been written by four researchers involved in the linkage grant. Four interviews on participants in the LDP were conducted by the authors to evaluate the effectiveness of the leadership program in order to prepare this paper. The study was carried out to clarify the research aim for the principal author (who is a PhD student in the ARC grant) by trying to understand what the LDP program was aiming to achieve and to be presented at the Spirituality at Work conference at the University of Arkansas

Towards a model for protein production rates

In the process of translation, ribosomes read the genetic code on an mRNA and assemble the corresponding polypeptide chain. The ribosomes perform discrete directed motion which is well modeled by a totally asymmetric simple exclusion process (TASEP) with open boundaries. Using Monte Carlo simulations and a simple mean-field theory, we discuss the effect of one or two ``bottlenecks'' (i.e., slow codons) on the production rate of the final protein. Confirming and extending previous work by Chou and Lakatos, we find that the location and spacing of the slow codons can affect the production rate quite dramatically. In particular, we observe a novel ``edge'' effect, i.e., an interaction of a single slow codon with the system boundary. We focus in detail on ribosome density profiles and provide a simple explanation for the length scale which controls the range of these interactions.Comment: 8 pages, 8 figure