130 research outputs found

    LHC Phenomenology of an Extended Standard Model with a Real Scalar Singlet

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    Gauge singlet extensions of the Standard Model (SM) scalar sector may help remedy its theoretical and phenomenological shortcomings while solving outstanding problems in cosmology. Depending on the symmetries of the scalar potential, such extensions may provide a viable candidate for the observed relic density of cold dark matter or a strong first order electroweak phase transition needed for electroweak baryogenesis. Using the simplest extension of the SM scalar sector with one real singlet field, we analyze the generic implications of a singlet-extended scalar sector for Higgs boson phenomenology at the Large Hadron Collider (LHC). We consider two broad scenarios: one in which the neutral SM Higgs and singlet mix and the other in which no mixing occurs and the singlet can be a dark matter particle. For the first scenario, we analyze constraints from electroweak precision observables and their implications for LHC Higgs phenomenology. For models in which the singlet is stable, we determine the conditions under which it can yield the observed relic density, compute the cross sections for direct detection in recoil experiments, and discuss the corresponding signatures at the LHC.Comment: 39 pages, 11 figures, 2 table

    Higgs Sector in Extensions of the MSSM

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    Extensions of the Minimal Supersymmetric Standard Model (MSSM) with additional singlet scalar fields solve the important mu-parameter fine tuning problem of the MSSM. We compute and compare the neutral Higgs boson mass spectra, including one-loop corrections, of the following MSSM extensions: Next-to-Minimal Supersymmetric Standard Model (NMSSM), the nearly-Minimal Supersymmetric Standard Model (nMSSM), and the U(1)'-extended Minimal Supersymmetric Standard Model (UMSSM) by performing scans over model parameters. We find that the Secluded U(1)'-extended Minimal Supersymmetric Standard Model (sMSSM) is identical to the nMSSM if three of the additional scalars decouple. The dominant part of the one-loop corrections are model-independent since the singlet field does not couple to MSSM particles other than the Higgs doublets. Thus, model-dependent parameters enter the masses only at tree-level. We apply constraints from LEP bounds on the Standard Model and MSSM Higgs boson masses and the MSSM chargino mass, the invisible Z decay width, and the Z-Z' mixing angle. Some extended models permit a Higgs boson with mass substantially below the SM LEP limit or above theoretical limits in the MSSM. Ways to differentiate the models via masses, couplings, decays and production of the Higgs bosons are discussed.Comment: 65 pages, 15 figures. Figure replaced and typos corrected. Version to appear in Phys. Rev.

    TeV physics and the Planck scale

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    Supersymmetry is one of the best motivated possibilities for new physics at the TeV scale. However, both concrete string constructions and phenomenological considerations suggest the possibility that the physics at the TeV scale could be more complicated than the Minimal Supersymmetric Standard Model (MSSM), e.g., due to extended gauge symmetries, new vector-like supermultiplets with non-standard SU(2)xU(1) assignments, and extended Higgs sectors. We briefly comment on some of these possibilities, and discuss in more detail the class of extensions of the MSSM involving an additional standard model singlet field. The latter provides a solution to the μ\mu problem, and allows significant modifications of the MSSM in the Higgs and neutralino sectors, with important consequences for collider physics, cold dark matter, and electroweak baryogenesis.Comment: 17 pages, 5 figures. To appear in New Journal of Physic

    A Systematic Review of Online Sex Addiction and Clinical Treatments Using CONSORT Evaluation

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    Researchers have suggested that the advances of the Internet over the past two decades have gradually eliminated traditional offline methods of obtaining sexual material. Additionally, research on cybersex and/or online sex addictions has increased alongside the development of online technology. The present study extended the findings from Griffiths’ (2012) systematic empirical review of online sex addiction by additionally investigating empirical studies that implemented and/or documented clinical treatments for online sex addiction in adults. A total of nine studies were identified and then each underwent a CONSORT evaluation. The main findings of the present review provide some evidence to suggest that some treatments (both psychological and/or pharmacological) provide positive outcomes among those experiencing difficulties with online sex addiction. Similar to Griffiths’ original review, this study recommends that further research is warranted to establish the efficacy of empirically driven treatments for online sex addiction

    Ancillary Therapy and Supportive Care of Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. Ancillary Therapy and Supportive Care Working Group Report

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    AbstractThe Ancillary Therapy and Supportive Care Working Group had 3 goals: (1) to establish guidelines for ancillary therapy and supportive care in chronic graft-versus-host disease (GVHD), including treatment for symptoms and recommendations for patient education, preventive measures, and appropriate follow-up; (2) to provide guidelines for the prevention and management of infections and other common complications of treatment for chronic GVHD; and (3) to highlight the areas with the greatest need for clinical research. The definition of “ancillary therapy and supportive care” embraces the most frequent immunosuppressive or anti-inflammatory interventions used with topical intent and any other interventions directed at organ-specific control of symptoms or complications resulting from GVHD and its therapy. Also included in the definition are educational, preventive, and psychosocial interventions with this same objective. Recommendations are organized according to the strength and quality of evidence supporting them and cover the most commonly involved organs, including the skin, mouth, female genital tract, eyes, gastrointestinal tract, and lungs. Recommendations are provided for prevention of infections, osteoporosis, and steroid myopathy and management of neurocognitive and psychosocial adverse effects related to chronic GVHD. Optimal care of patients with chronic GVHD often requires a multidisciplinary approach

    Technology mediator: a new role for the reference librarian?

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    The Arizona Health Sciences Library has collaborated with clinical faculty to develop a federated search engine that is useful for meeting real-time clinical information needs. This article proposes a technology mediation role for the reference librarian that was inspired by the project, and describes the collaborative model used for developing technology-mediated services for targeted users

    Critical Thinking in Nursing Education: Literature Review

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    The need for critical thinking in nursing has been accentuated in response to the rapidly changing health care environment. Nurses must think critically to provide effective care whilst coping with the expansion in role associated with the complexities of current health care systems. This literature review will present a history of inquiry into critical thinking and research to support the conclusion that critical thinking is necessary not only in the clinical practice setting, but also as an integral component of nursing education programs to promote the development of nurses’ critical thinking abilities. The aims of this paper are: (a) to review the literature on critical thinking; (b) to examine the dimensions of critical thinking; (c) to investigate the various critical thinking strategies for their appropriateness to enhance critical thinking in nurses, and; (d) to examine issues relating to evaluation of critical thinking skills in nursing.</ul

    Attenuated Food Anticipatory Activity and Abnormal Circadian Locomotor Rhythms in Rgs16 Knockdown Mice

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    Regulators of G protein signaling (RGS) are a multi-functional protein family, which functions in part as GTPase-activating proteins (GAPs) of G protein α-subunits to terminate G protein signaling. Previous studies have demonstrated that the Rgs16 transcripts exhibit robust circadian rhythms both in the suprachiasmatic nucleus (SCN), the master circadian light-entrainable oscillator (LEO) of the hypothalamus, and in the liver. To investigate the role of RGS16 in the circadian clock in vivo, we generated two independent transgenic mouse lines using lentiviral vectors expressing short hairpin RNA (shRNA) targeting the Rgs16 mRNA. The knockdown mice demonstrated significantly shorter free-running period of locomotor activity rhythms and reduced total activity as compared to the wild-type siblings. In addition, when feeding was restricted during the daytime, food-entrainable oscillator (FEO)-driven elevated food-anticipatory activity (FAA) observed prior to the scheduled feeding time was significantly attenuated in the knockdown mice. Whereas the restricted feeding phase-advanced the rhythmic expression of the Per2 clock gene in liver and thalamus in the wild-type animals, the above phase shift was not observed in the knockdown mice. This is the first in vivo demonstration that a common regulator of G protein signaling is involved in the two separate, but interactive circadian timing systems, LEO and FEO. The present study also suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s)
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