A unique case of recurrent uterine inversion requiring double reposition

Acute puerperal uterine inversion is a rare but life threatening complication of third stage of labour. The incidence varies widely between 1 in 2000 to 1 in 50,000 deliveries, largely dependent upon the standard of management of the third stage of labour. Acute uterine inversion occurs within 24 hours delivery; subacute between 24 hours and 4 weeks of delivery and chronic uterine inversion after 4 weeks or in the non pregnant state. Cases of subacute and chronic uterine inversion require surgical management

Where is the bride? Progressively declining sex ratio in India: an alarming signal for imbalanced society

Female feticide is an extreme form of violence against women, the most active part is being played by the women themselves just for the mere want of a boy, mothers don't feel bad in strangulating their own daughters in their wombs. From decades of sex determination and female feticide is creating a statistical imbalance regarding the commonly expected ‘male: female’ birth ratio in India. This offense have been spreaded to the states in India like Punjab, Haryana, Delhi, Gujarat and Rajasthan, with the news of increasing number of female fetus being aborted from Orissa & Bangalore. The 2011 census has revealed a drastic fall in child sex ratio throughout the country. The decline in child sex ratio in India is guarded by the census figure, in 1991 the figure was 947 girls to 1000 boys, ten years later in 2001 it was about for 927 girl child to 1000 boys. In 2011 it further declined to 914 girl children to 1000 boys

Status of vitamin D, paratharmone and serum calcium levels in perimenopausal women and their mutual correlation

Background: The present study was carried out with an aim to assess Vitamin D, parathyroid hormone and calcium status in perimenopausal women and to find out their mutual correlation.Methods: The present work was carried out on in the Department of Obstetrics and Gynaecology, in collaboration with Department of Biochemistry at Era's Lucknow Medical College and Hospitals, Lucknow, U.P. 80 healthy females aged 40-50 years were included in the study. Serum vitamin D, parathyroid hormone and calcium levels were assessed. Data was analyzed using ANOVA and Pearson correlation coefficient.Results: Osteopenia and osteoporosis was seen in 33 (41.3%) and 21 (26.3%) women respectively, 50 (62.5%) women had S. vitamin D levels 0.05). Correlation between Vitamin D levels and Parathyroid hormone levels was weak and not significant.Conclusions: The findings of present study highlighted that perimenopausal phase should be regarded as a transition phase where a lot of physiological changes take place resulting in bone mineral density loss and fall in serum hormonal, vitamin and mineral levels. Owing to tremendous continuing changes the relationship between these parameters is vitiated and does not show a systematic change.

Food Nanotechnologies: Purchasing a Double Edge Sword

Rapid development of nanotechnology has revolutionsed various areas of conventional food science and food industry. The novel properties of nanoparticles (NPs) have led to increasing application of nanotechnology in food industry. Nanofood market have a variety of products like the creamy ice-cream, drinks with no fat, enhanced flavour with nutrients and better textured, coloured and fresh looking food. Continuous monitoring for food spoilage or contamination is possible too. Nanotechnology has transformed the food industries which claim health benefits along with better taste. With the increasing use of NPs especially in food products, where humans are in close contact of the engineered nanomaterials (NMs), it is important to ensure safety before use. Bio-nano interactions often result in novel reaction and formation of products leading to toxicity. NPs mediated toxicity mainly includes inflammation, oxidative damage and genotoxicity. Prolong use of these particles can cause detrimental effects on health. Presently, due to lack of appropriate guidelines and regulations for food nanotechnology there are uncertainties regarding risk identification. Hence, it is essential to evaluate the consequences of this technology in terms of general public and occupational health risks associated with the manufacture, use and disposal of NMs, before instigating the same in day to day use

Racial Disparities in the Genetic Landscape of Lung Cancer

Lung cancer has the highest cancer-related mortality worldwide and in the United States. Reduced tobacco consumption and advancement in therapies have led to a modest decline in lung cancer death rates over the past two decades; the overall survival rate is still disappointing.  Moreover, race-associated disparities are also observed, especially in the clinical outcomes. While differences in socioeconomic status and lifestyle could be significant contributing factors, differences in the genetic landscape of lung cancer among different racial groups have also been reported.  In this review, we shed light on the genetic heterogeneity of lung cancer and race-associated differences in genetic alterations to build a framework for future studies to understand the biological basis of lung cancer disparities

SUPFAM: A database of sequence superfamilies of protein domains

BACKGROUND: SUPFAM database is a compilation of superfamily relationships between protein domain families of either known or unknown 3-D structure. In SUPFAM, sequence families from Pfam and structural families from SCOP are associated, using profile matching, to result in sequence superfamilies of known structure. Subsequently all-against-all family profile matches are made to deduce a list of new potential superfamilies of yet unknown structure. DESCRIPTION: The current version of SUPFAM (release 1.4) corresponds to significant enhancements and major developments compared to the earlier and basic version. In the present version we have used RPS-BLAST, which is robust and sensitive, for profile matching. The reliability of connections between protein families is ensured better than before by use of benchmarked criteria involving strict e-value cut-off and a minimal alignment length condition. An e-value based indication of reliability of connections is now presented in the database. Web access to a RPS-BLAST-based tool to associate a query sequence to one of the family profiles in SUPFAM is available with the current release. In terms of the scientific content the present release of SUPFAM is entirely reorganized with the use of 6190 Pfam families and 2317 structural families derived from SCOP. Due to a steep increase in the number of sequence and structural families used in SUPFAM the details of scientific content in the present release are almost entirely complementary to previous basic version. Of the 2286 families, we could relate 245 Pfam families with apparently no structural information to families of known 3-D structures, thus resulting in the identification of new families in the existing superfamilies. Using the profiles of 3904 Pfam families of yet unknown structure, an all-against-all comparison involving sequence-profile match resulted in clustering of 96 Pfam families into 39 new potential superfamilies. CONCLUSION: SUPFAM presents many non-trivial superfamily relationships of sequence families involved in a variety of functions and hence the information content is of interest to a wide scientific community. The grouping of related proteins without a known structure in SUPFAM is useful in identifying priority targets for structural genomics initiatives and in the assignment of putative functions. Database URL:

RISK FACTOR ASSESSMENT FOR ACNE VULGARIS IN HUMAN AND IMPLICATIONS FOR PUBLIC HEALTH INTERVENTIONS IN NORTH CENTRAL INDIA: A SURVEY-BASED STUDY

Background: Acne vulgaris is a very common dermatological problem of adolescence since the time immemorial. However, it is neither life threatening nor is a physical disability, but acne affects social and psychological functioning. Acne vulgaris is multifactorial, apart from basic factor of hormonal change and bacterial outbreak; there are several other factors that may influence the prevalence of acne.Methods: In the present study, populations were assessed for influence of various factors on acne prevalence. This cross-sectional study was a population based field study intending to discern the factors that influence the prevalence of acne in adolescents. The study carried out from April 2016 to October 2016 in north central India. For this survey, questionnaires were design to cover all the required information regarding occurrence of acne that include factors like gender, age, skin type, complexion, season of occurrence, dietary habit etc.Results: Acne vulgaris appears to be influenced by gender, age, seasonal variations, breakout area, complexion, skin types and dietary habits. Further, the influence of dietary habit on acne, by the consumption of dairy products or high-carbon diet has also been evaluated. Apart from depicting the vulnerable range of age (p=0.003288), sensitivity on various skin types (p=0.00039) and complexion (p=0.001355) on the basis of gender; This Field study on Acne Vulgaris, also reveals that the season has inordinate role in acne pervasiveness (p=0.115731).Conclusion: This study is helpful in categorizing the risk factors and evidencing the afflictions of acne in population thus, contributing health care planning. Â

PHARMACOLOGICAL STUDIES OF OCIMUM BASILICUM L.

Ocimum basilicum (O. basilicum) L. belongs to family Lamiaceae which comprises the most employed medicinal plants as a worldwide source of spices and also as a consolidated source of extracts. The phytochemical constituents of sweet basil essential oil have been investigated for several therapeutic importance from many regions of the world. They include terpenoids, alkaloids, flavonoids, tannins, saponin glycosides and ascorbic acid. These compounds have been reported to exhibit antibacterial and antifungal, antidyspepsia, anti-inflammatory, antioxidant, antiulcer, antiviral, insecticidal, wound-healing etc. activities. The plant parts of O. basilicum have been widely used in preparation traditional medicine. The plants also been used as a folk remedy to treat various ailments such as feverish illness, poor digestion, nausea, abdominal cramps, gastro-enteritis, migraine, insomnia, depression, gonorrhea, dysentery etc. Externally, they have been applied for the treatment of acne, loss of smell, insect stings, snake bites and skin infections. The present review is aimed to cover the pharmacological investigations on this important medicinal herb. Key Words: Ocimum basilicum, phytochemical constituents, antiinflammatory, antioxidant, antiviral, insecticida