A cost variation analysis of various brands of oral anti-diabetic drugs currently available in Indian pharmaceutical market

Background: Diabetes mellitus is a metabolic disorder requiring lifelong treatment. There are a large number of anti-diabetic drugs available in the Indian market.  The cost of drugs plays an important role in patient’s care, warranting the need for all physicians to keep themselves updated with the latest prices and price variation of various brands of anti-diabetic drugs. The objective of this study is to evaluate the cost of oral anti-diabetic drugs of different brands currently available in the Indian market.Methods: Cost of oral anti-diabetic drugs manufactured by different pharmaceutical companies in the same strength and dosage forms was obtained. The percentage price variation and cost ratio for each formulation was calculated.Results: In sulfonylurea group of drugs, maximum price variation was seen in glimepiride 1mg 1366% and minimum was seen in glipizide 2.5 mg 17%. In non-sulfonylurea group of drugs, a maximum variation was seen in metformin 500 mg 809% and a minimum variation was seen in acarbose 100 mg 10%. Among the fixed dose combination therapy, glimepiride 2 mg and metformin 500 mg showed the highest price variation 555% and pioglitazone 7.5 mg and metformin 500 mg showed the least price variation 8%.Conclusions: Our study showed that there is a very high price variation for oral anti-diabetic drugs by different brands. Since diabetes mellitus is a chronic illness, cost of the drug plays an important role in compliance to the treatment regimen. It is necessary to bring awareness regarding this wide variation in prices, such that the drug costs can be reduced and made more affordable to the common man

Maternal Cardiovascular Outcomes of Pregnancy in Childhood, Adolescent, and Young Adult Cancer Survivors

This review focuses on the maternal cardiovascular risk and outcomes of pregnancy in childhood, adolescent, and young adult cancer survivors who are achieving survival to their prime reproductive years. Childhood, adolescent, and young adult cancer survivors are a growing population and have increasing needs for reproductive care over decades of life. Female cancer survivors have an overall higher risk of maternal cardiovascular events compared to those without a history of cancer. In female cancer survivors with normal cardiac function before pregnancy, the incidence of new heart failure during pregnancy is low. In survivors with cardiotoxicity prior to pregnancy, the risk of heart failure during and immediately after pregnancy is much higher. We recommend cardiomyopathy surveillance with echocardiography before pregnancy for all female survivors treated with anthracyclines and chest radiation. Survivors with cardiotoxicity prior to pregnancy should be cared for by an expert multidisciplinary team, including obstetrics, cardiology, anesthesia, and specialized nursing, among others

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi