Additional file 2: Figure S1. of Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

H3K4me3 ChIP-on-chip analysis in the livers of A/J and WSB/EiJ mice fed a choline- and folate-deficient diet. Heat map illustrating significant differences in hepatic H3K4me3-enrichment of CpG islands between A/J (a) and WSB/EiJ (b) mice fed the CFD diet. Unsupervised hierarchical clustering analysis was performed using one-way ANOVA with p value cut-off at 0.05. The color bar identifies high-H3K4me3-enriched (red) and low-H3K4me3-enriched (green) genes. (c) Table showing number of differentially H3K4me3-enriched CpG islands in hepatic DNA in A/J and WSB/EiJ mice fed a control or CFD diet. Ratio IP/input DNA was calculated using ArrayTrack application. (TIFF 1501 kb

Correlations between variables entering the logistic regression model.

<p>* Significant correlation <0.4.</p><p>** Significant correlation 0.4–0.6.</p><p>*** Significant correlation >0.6.</p><p>Correlations between variables entering the logistic regression model.</p

Predicted average daily computer screen time hours based on the normal group age regression model.

<p>CST–Computer screen time.</p

Mean daily computer screen time (hours) of the normal and psychopathology groups, at different developmental stages.

<p>* Borderline significant difference; ** Significant difference; Error bars represent ±1 standard error. CST–Computer Screen Time.</p