7 research outputs found
An Observational Cohort Comparison of Facilitators of Retention in Care and Adherence to Anti-Eetroviral Therapy at an HIV Treatment Center in Kenya
BACKGROUND: Most HIV treatment programs in resource-limited settings utilize multiple facilitators of adherence and retention in care but there is little data on the efficacy of these methods. We performed an observational cohort analysis of a treatment program in Kenya to assess which program components promote adherence and retention in HIV care in East Africa. METHODS: Patients initiating ART at A.I.C. Kijabe Hospital were prospectively enrolled in an observational study. Kijabe has an intensive program to promote adherence and retention in care during the first 6 months of ART that incorporates the following facilitators: home visits by community health workers, community based support groups, pharmacy counseling, and unannounced pill counts by clinicians. The primary endpoint was time to treatment failure, defined as a detectable HIV-1 viral load; discontinuation of ART; death; or loss to follow-up. Time to treatment failure for each facilitator was calculated using Kaplan-Meier analysis. The relative effects of the facilitators were determined by the Cox Proportional Hazards Model. RESULTS: 301 patients were enrolled. Time to treatment failure was longer in patients participating in support groups (448 days vs. 337 days, P<0.001), pharmacy counseling (480 days vs. 386 days, P = 0.002), pill counts (482 days vs. 189 days, P<0.001) and home visits (485 days vs. 426 days, P = 0.024). Better adherence was seen with support groups (89% vs. 82%, P = 0.05) and pill counts (89% vs. 75%, P = 0.02). Multivariate analysis using the Cox Model found significant reductions in risk of treatment failure associated with pill counts (HR = 0.19, P<0.001) and support groups (HR = 0.43, P = 0.003). CONCLUSION: Unannounced pill counts by the clinician and community based support groups were associated with better long term treatment success and with better adherence
Time to Treatment Failure Categorized by Interventions.
<p>Kaplan Meier plots of time to treatment failure stratified by: A) participation in two or more support group meetings; B) having four or more unannounced pill counts by primary care provider; C) at least one home visit; D) having two or more counseling sessions by a pharmacist.</p
Schematic Diagram of HIV Program and Observational Study Design.
<p>The HIV program is divided into 3 distinct activities, HIV testing, Treatment Preparation, and Antiretroviral treatment that includes both community and clinic based facilitators. For entry into the study, subjects must be HIV positive and complete all treatment preparation activities. The study period begins with initiation of ART and evaluates the effects of treatment facilitators on treatment success.</p
Comparisons of Treatment Success and Failures.
<p>Comparisons of Treatment Success and Failures.</p
Rates of Adherence Categorized by Interventions.
<p>Rates of adherence in treatment successes and failures is shown by each intervention: 1) greater than one home visit; 2) participation in two or more support groups; 3) having four or more unannounced pill counts by primary care provider; 4) having two or more counseling sessions by a pharmacist; 5) completing six or more clinic visits.</p
Multivariate Analysis of Risk of Failure.
<p>(Cox Proportional Hazards Model). P>0.05 for interactions.</p