Long-term risk of hysterectomy and ectopic pregnancy among Vietnamese women using the quinacrine hydrochloride pellet system vs. intrauterine devices or tubal ligation for contraception

<p><b>Objectives:</b> Determine the long-term risk of hysterectomy and ectopic pregnancy in women using the quinacrine hydrochloride pellet system of permanent contraception (QS) relative to the comparable risk in women using Copper T intrauterine device (IUD) or tubal ligation surgery (TL) for long-term or permanent contraception.</p> <p><b>Methods:</b> This was a retrospective cohort study, conducted in the Northern Vietnamese provinces of Ha Nam, Nam Dinh, Ninh Binh and Thai Binh. Women who had their first QS procedure, last IUD insertion or TL between 1989 and 1996 were interviewed regarding post-procedure health outcomes approximately 16 years post exposure.</p> <p><b>Results:</b> A 95% response rate resulted in 21,040 completed interviews. Overall incidence rates were low for both outcomes (91/100,000 women years of follow-up and 22/100,000 women years of follow-up for hysterectomy and ectopic pregnancy, respectively). After accounting for variations in baseline characteristics between women choosing QS vs. the other two contraceptive methods, no significant excess hazard of either hysterectomy or ectopic pregnancy was associated with QS.</p> <p><b>Conclusions:</b> No significant excess long-term risk of hysterectomy or ectopic pregnancy was found among a large group of women using QS vs. IUD or TL for contraception after an average 16 years of follow-up.</p

Additional file 1: Table S1. of Key influence of sex on urine volume and osmolality

Bivariate associations for variables that did not pass stepwise linear model selection criteria. Figure S1. Analysis of biological sex on variability in urine osmolality (A) and urine volume (B). (DOCX 50 kb

L'Alerte : journal indépendant : politique, littéraire et commercial

04 mars 19121912/03/04 (A16)-1912/03/04

Additional file 5: of Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

Individual SNP information for unique SNPs reaching genome-wide suggestive p -value threshold for MESA ethnicity-specific GWAS analyses for each methodological approach (MAF > 5 %, INFO > 0.8, LD R 2  < 0.80). (PDF 110 kb

Intervention dans le Podcast les Arts du FLE pour faire le point sur la perspective actionnelle en classe de langues

Ce podcast est disponible en ligne, à l'adresse suivante :https://agi.to/podcast/arts-du-fle-08-actionne-ton-approche/Ce numéro 8 des Arts du FLE (émission spécialisée en FLE) propose un dossier spécial approches pédagogiques et perspective actionnelle. J'en suis l'invitée et j'y réponds de manière détaillée pendant près d'une heure aux questions de l'animateur et créateur de ce Podcast, Sébastien Durietz (en poste actuellement à l'ONU, à New-York)

Additional file 6: Figures S1–S4. of DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

(PDF 1036 kb

Additional file 10: Table S9. of DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Significant associations between DNA methylation and corresponding nearby genetic variants and between the genetic variant and CRP in the largest published GWAS of CRP (n = 66,185). (XLSX 12 kb

Additional file 9: Table S8. of DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Significant methylation-expression results and corresponding expression-CRP results for the replicated CpGs. (XLSX 11 kb