Antiulcer Potential of the Ethanolic Extract of Aerva Persica Merrill Root in Rats

AbstractThe ethanol extract of the roots of Aerva persica (Burm f) Merrill (Amaranthaceae) was investigated to determine its antiulcer and in vivo antioxidant activities in albino Wistar rats. Ulcers were induced by ethanol and pylorus ligation. The extract was administered at the dose of 200mg/kg orally, p.o. for 15 consecutive days. The ulcer index of the ethanol extract was found to be significantly reduced compared with control animals. The effect was also assessed by determining the free acidity, pepsin activity, total carbohydrate (TC), and protein content (PK) in control, standard, and test group animals. The in vivo antioxidant activity was evaluated by determining the reduced glutathione level (GSH) and malondialdehyde (MDA) level in the tissue homogenates. The results reveal the significant reduction in the level of malondialdehyde and the increase in the level of reduced glutathione in the rats that received the ethanolic extract. Furthermore, histopathological studies have shown that pretreatment with the ethanolic extract of the roots of A persica reduces (100%) ethanol- and pylorus ligation-induced hemorrhagic necrosis in rats

In Vitro Antioxidant Activity of root extracts of Heliotropium eichwaldi Stued. ex DC

ABSTRACT In vitro antioxidant activity of methanolic and aqueous root extracts of Heliotropium eichwaldi Stued. ex DC. was determined by DPPH free radical scavenging assay and hydrogen peroxide scavenging activity. The extract revealed marked activity as a radical scavenger in a study indicating that extracts have ability to donate hydrogen. The absorption is stoichiometric in respect to the number of electrons taken up. Concentration of 0.1 mg/ml of methanolic extract (HME) and aqueous root extract (HAE) of Heliotropium eichwaldi exhibited 62.73% and 57.18% DPPH scavenging activity. The antioxidant activity of these extracts towards hydrogen peroxide was also reported. A 76.94% and 70.79% of inhibition of hydrogen peroxide was observed with HME and HAE respectively, when compared with control, at a concentration of 0.1 mg/ml using ascorbic acid as standard and positive control on analysis with UV-Visible Spectrophotometer. The results conclude that the extracts are a potential source of antioxidants of natural origin and may be a candidate for treating pathologies related to free radical oxidation due to its overall antioxidant effect in scavenging free radicals and active oxygen species

A new aliphatic acid from <i style="">Achyranthes aspera</i> Linn. Roots

1164-1169A total of six compounds isolated from the ethanol extract of the roots of Achyranthes aspera Linn. (Amaranthaceae) are characterised as strigmasta-5, 22-dien-3-β-ol, trans-13-docasenoic acid, n-hexacosanyl n-decaniate, n-hexacos-17-enoic acid and n-hexacos-11-enoic acid on basis of spectral data and chemical means, including a new aliphatic acid, n-hexacos-14-enoic acid which is being reported for the first time from natural and synthetic source.</i

PHYTOCHEMICAL INVESTIGATION OF CAYRATIA TRIFOLIA (LINN.) DOMIN STEM

ABSTRACT In the present investigation the methanol extract of Cayratia trifolia (Linn.) Domin stem was used for the isolation of phytoconstituents by using column chromatography. The identification of the isolated constituents was done by using spectroscopicanalysis. Five new compounds namely are ntetradecanyl n-octadec-9, 12-dienoate, n-tridecanyl n-octadec-9, 12-dienoate, n-hexadecanyl n-octadec-9, 12-dienoate, n-tetradecanyl n-octadec-9-enoate and n-hexadecanyl n-octadec-9-enoate were isolated and identified from theplant. Keywords: Cayratia trifolia (Linn.) Domin,Vitaceae, n-tetradecanyl n-octadec-9, 12-dienoate, n-tridecanyl n-octadec-9, 12-dienoate, n-hexadecanyl n-octadec-9, 12-dienoate, n-tetradecanyl n-octadec-9-enoate and n-hexadecanyl n-octadec-9-enoate