The number of privately treated tuberculosis cases in India: an estimation from drug sales data

Background Understanding the amount of tuberculosis managed by the private sector in India is crucial to understanding the true burden of the disease in the country, and thus globally. In the absence of quality surveillance data on privately treated patients, commercial drug sales data offer an empirical foundation for disease burden estimation. Methods We used a large, nationally representative commercial dataset on sales of 189 anti-tuberculosis products available in India to calculate the amount of anti-tuberculosis treatment in the private sector in 2013–14. We corrected estimates using validation studies that audited prescriptions against tuberculosis diagnosis, and estimated uncertainty using Monte Carlo simulation. To address implications for numbers of patients with tuberculosis, we explored varying assumptions for average duration of tuberculosis treatment and accuracy of private diagnosis. Findings There were 17·793 million patient-months (95% credible interval 16·709 million to 19·841 million) of anti-tuberculosis treatment in the private sector in 2014, twice as many as the public sector. If 40–60% of private-sector tuberculosis diagnoses are correct, and if private-sector tuberculosis treatment lasts on average 2–6 months, this implies that 1·19–5·34 million tuberculosis cases were treated in the private sector in 2014 alone. The midpoint of these ranges yields an estimate of 2·2 million cases, two to three times higher than currently assumed. Interpretation India's private sector is treating an enormous number of patients for tuberculosis, appreciably higher than has been previously recognised. Accordingly, there is a re-doubled need to address this burden and to strengthen surveillance. Tuberculosis burden estimates in India and worldwide require revision

The BCS theory of q-deformed nucleon pairs - qBCS

We construct a coherent state of q-deformed zero coupled nucleon pairs distributed in several single-particle orbits. Using a variational approach, the set of equations of qBCS theory, to be solved self consistently for occupation probabilities, gap parameter Delta, and the chemical potential lambda, is obtained. Results for valence nucleons in nuclear degenerate sdg major shell show that the strongly coupled zero angular momentum nucleon pairs can be substituted by weakly coupled q-deformed zero angular momentum nucleon pairs. A study of Sn isotopes reveals a well defined universe of (G, q) values, for which qBCS converges. While the qBCS and BCS show similar results for Gap parameter Delta in Sn isotopes, the ground state energies are lower in qBCS. The pairing correlations in N nucleon system, increase with increasing q (for q real).Comment: 8 pages, REVTEX, 3 eps figure

Baryon Self-Energy With QQQ Bethe-Salpeter Dynamics In The Non-Perturbative QCD Regime: n-p Mass Difference

A qqq BSE formalism based on DB{\chi}S of an input 4-fermion Lagrangian of `current' u,d quarks interacting pairwise via gluon-exchange-propagator in its {\it non-perturbative} regime, is employed for the calculation of baryon self-energy via quark-loop integrals. To that end the baryon-qqq vertex function is derived under Covariant Instantaneity Ansatz (CIA), using Green's function techniques. This is a 3-body extension of an earlier q{\bar q} (2-body) result on the exact 3D-4D interconnection for the respective BS wave functions under 3D kernel support, precalibrated to both q{\bar q} and qqq spectra plus other observables. The quark loop integrals for the neutron (n) - proton (p) mass difference receive contributions from : i) the strong SU(2) effect arising from the d-u mass difference (4 MeV); ii) the e.m. effect of the respective quark charges. The resultant n-p difference comes dominantly from d-u effect (+1.71 Mev), which is mildly offset by e.m.effect (-0.44), subject to gauge corrections. To that end, a general method for QED gauge corrections to an arbitrary momentum dependent vertex function is outlined, and on on a proportionate basis from the (two-body) kaon case, the net n-p difference works out at just above 1 MeV. A critical comparison is given with QCD sum rules results.Comment: be 27 pages, Latex file, and to be published in IJMPA, Vol 1

Phytoplanktonic diversity in lake Jaisamand, Rajasthan (India)

The present study describes the diversity of phytoplankton in the lake Jaisamand of Rajasthan (India). Results depict that phytoplankton was contributed by six major groups which comprised total 85 species. Out of which 13 belongs to Myxophyceae, 5 to Euglenophyceae, 38 to Chlorophyceae, 3 to Xanthophyceae, 1 to Cryptophyceae and 23 to Bacillariophyceae. Thus, Bacillariophyceae and Chlorophyceae turned up as the dominant groups in terms of density (159-554 numbers per liter and 24-485 numbers per liter) and species number (23 and 38), respectively. It was revealed that Jaisamand Lake maintained fairly good population of phytoplankton which is indication of providing broad base for achieving high productivity in this water body