Effect of ammonium fluoride doping on the ice III to ice IX phase transition

Ice III is a hydrogen-disordered phase of ice that is stable between about 0.2 and 0.35 GPa. Upon cooling, it transforms to its hydrogen-ordered counterpart ice IX within the stability region of ice II. Here, the effect of ammonium fluoride doping on this phase transition is investigated, which is followed for the first time with in situ neutron diffraction. The a and c lattice constants are found to expand and contract, respectively, upon hydrogen ordering, yielding an overall negative volume change. Interestingly, the anisotropy in the lattice constants persists when ice IX is fully formed, and negative thermal expansion is observed. Analogous to the isostructural keatite and β-spodumenes, the negative thermal expansion can be explained through the buildup of torsional strain within the a–b plane as the helical “springs” within the structure expand upon heating. The reversibility of the phase transition was demonstrated upon heating. As seen in diffraction and Raman spectroscopy, the ammonium fluoride doping induces additional residual hydrogen disorder in ice IX and is suggested to be a chemical way for the “excitation” of the configurational ice-rules manifold. Compared to ice VIII, the dopant-induced hydrogen disorder in ice IX is smaller, which suggests a higher density of accessible configurational states close to the ground state in ice IX. This study highlights the importance of dopants for exploring the water’s phase diagram and underpins the highly complex solid-state chemistry of ice

Teleparallel Killing Vectors of Spherically Symmetric Spacetimes

In this paper, Killing vectors of spherically spacetimes have been evaluated in the context of teleparallel theory of gravitation. Further, we investigate the Killing vectors of the Friedmann metrics. It is found that for static spherically spacetimes the number of Killing vectors turn out to be \emph{seven} while for the Friedmann models, we obtain \emph{six} teleparallel Killing vectors. The results are then compared with those of General Relativity. We conclude that both of these descriptions of gravity do not provide the consistent results in general. However, these results may coincide under certain conditions for a particular spacetime.Comment: 14 pages, accepted for publication in Communications in Theoretical Physic

‘We need to share our stories’: the lives of Pakistanis with intellectual disability and their guardians

© 2020 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd Introduction: The experiences of Pakistanis with intellectual disabilities (IDs) and their family members have been underexplored empirically. Method: The present study sought to address this gap by understanding the lives of five Special Olympics Pakistan athletes and their guardians through PhotoVoice. Findings: Through thematic analysis, we present the primary theme concerning Pakistan\u27s cultural context that provides an empirical exploration of cultural beliefs about intellectual disability, cultural expectations and support received by people with intellectual disabilities and their guardians. Discussion: We discuss implications for research and practice

Bianchi type II models in the presence of perfect fluid and anisotropic dark energy

Spatially homogeneous but totally anisotropic and non-flat Bianchi type II cosmological model has been studied in general relativity in the presence of two minimally interacting fluids; a perfect fluid as the matter fluid and a hypothetical anisotropic fluid as the dark energy fluid. The Einstein's field equations have been solved by applying two kinematical ans\"{a}tze: we have assumed the variation law for the mean Hubble parameter that yields a constant value of deceleration parameter, and one of the components of the shear tensor has been considered proportional to the mean Hubble parameter. We have particularly dwelled on the accelerating models with non-divergent expansion anisotropy as the Universe evolves. Yielding anisotropic pressure, the fluid we consider in the context of dark energy, can produce results that can be produced in the presence of isotropic fluid in accordance with the \Lambda CDM cosmology. However, the derived model gives additional opportunities by being able to allow kinematics that cannot be produced in the presence of fluids that yield only isotropic pressure. We have obtained well behaving cases where the anisotropy of the expansion and the anisotropy of the fluid converge to finite values (include zero) in the late Universe. We have also showed that although the metric we consider is totally anisotropic, the anisotropy of the dark energy is constrained to be axially symmetric, as long as the overall energy momentum tensor possesses zero shear stress.Comment: 15 pages; 5 figures; matches the version published in The European Physical Journal Plu

Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries

OBJECTIVE: In resistance arteries, diameter adjustment in response to pressure changes depends on the vascular cytoskeleton integrity. Serum response factor (SRF) is a dispensable transcription factor for cellular growth, but its role remains unknown in resistance arteries. We hypothesized that SRF is required for appropriate microvascular contraction. METHODS AND RESULTS: We used mice in which SRF was specifically deleted in smooth muscle or endothelial cells, and their control. Myogenic tone and pharmacological contraction was determined in resistance arteries. mRNA and protein expression were assessed by quantitative real-time PCR (qRT-PCR) and Western blot. Actin polymerization was determined by confocal microscopy. Stress-activated channel activity was measured by patch clamp. Myogenic tone developing in response to pressure was dramatically decreased by SRF deletion (5.9+/-2.3%) compared with control (16.3+/-3.2%). This defect was accompanied by decreases in actin polymerization, filamin A, myosin light chain kinase and myosin light chain expression level, and stress-activated channel activity and sensitivity in response to pressure. Contractions induced by phenylephrine or U46619 were not modified, despite a higher sensitivity to p38 blockade; this highlights a compensatory pathway, allowing normal receptor-dependent contraction. CONCLUSIONS: This study shows for the first time that SRF has a major part to play in the control of local blood flow via its central role in pressure-induced myogenic tone in resistance arteries

Osmosensitivity of Transient Receptor Potential Vanilloid 1 Is Synergistically Enhanced by Distinct Activating Stimuli Such as Temperature and Protons

In animals, body-fluid osmolality is continuously monitored to keep it within a narrow range around a set point (∼300 mOsm/kg). Transient receptor potential vanilloid 1 (TRPV1), a cation channel, has been implicated in body-fluid homeostasis in vivo based on studies with the TRPV1-knockout mouse. However, the response of TRPV1 to hypertonic stimuli has not been demonstrated with heterologous expression systems so far, despite intense efforts by several groups. Thus, the molecular entity of the hypertonic sensor in vivo still remains controversial. Here we found that the full-length form of TRPV1 is sensitive to an osmotic increase exclusively at around body temperature using HEK293 cells stably expressing rat TRPV1. At an ambient temperature of 24°C, a slight increase in the intracellular calcium concentration ([Ca2+]i) was rarely observed in response to hypertonic stimuli. However, the magnitude of the osmosensitive response markedly increased with temperature, peaking at around 36°C. Importantly, the response at 36°C showed a robust increase over a hypertonic range, but a small decrease over a hypotonic range. A TRPV1 antagonist, capsazepine, and a nonspecific TRP channel inhibitor, ruthenium red, completely blocked the increase in [Ca2+]i. These results endorse the view that the full-length form of TRPV1 is able to function as a sensor of hypertonic stimuli in vivo. Furthermore, we found that protons and capsaicin likewise synergistically potentiated the response of TRPV1 to hypertonic stimuli. Of note, HgCl2, which blocks aquaporins and inhibits cell-volume changes, significantly reduced the osmosensitive response. Our findings thus indicate that TRPV1 integrates multiple different types of activating stimuli, and that TRPV1 is sensitive to hypertonic stimuli under physiologically relevant conditions