An isotropic antenna based on Rydberg atoms

Governed by the hairy ball theorem, classical antennas with isotropic responses to linearly polarized radio waves are unrealizable. This work shows that the antenna based on Rydberg atoms can theoretically achieve an ideal isotropic response to linearly polarized radio waves; that is, it has zero isotropic deviation. Experimental results of isotropic deviation within 5 dB, and 0.3 dB achievable after optimization, in microwave and terahertz wave measurements support the theory and are at least 15 dB improvement than the classical omnidirectional antenna. Combined with the SI traceable and ultrawideband property, the ideal isotropic response will make radio wave measurement based on atomic antenna much more accurate and reliable than the traditional method. This isotropic atomic antenna is an excellent example of what a tailored quantum sensor can realize, but a classical sensor cannot. It has crucial applications in fields such as radio wave electrometry

High bandwidth laser-frequency-locking for wideband noise suppression

Ultra-low frequency noise lasers have been widely used in laser-based experiments. Most narrow-linewidth lasers are implemented by actively suppressing their frequency noise through a frequency noise servo loop (FNSL). The loop bandwidths (LBW) of FNSLs are currently below megahertz, which is gradually tricky to meet application requirements, especially for wideband quantum sensing experiments. This article has experimentally implemented an FNSL with loop-delay-limited 3.5 MHz LBW, which is an order higher than the usual FNSLs. Using this FNSL, we achieved 70 dB laser frequency noise suppression over 100 kHz Fourier frequency range. This technology has broad applications in vast fields where wideband laser frequency noise suppression is inevitable

Noise analysis of the atomic superheterodyne receiver based on flat-top laser beams

Since its theoretical sensitivity is limited by quantum noise, radio wave sensing based on Rydberg atoms has the potential to replace its traditional counterparts with higher sensitivity and has developed rapidly in recent years. However, as the most sensitive atomic radio wave sensor, the atomic superheterodyne receiver lacks a detailed noise analysis to pave its way to achieve theoretical sensitivity. In this work, we quantitatively study the noise power spectrum of the atomic receiver versus the number of atoms, where the number of atoms is precisely controlled by changing the diameters of flat-top excitation laser beams. The results show that under the experimental conditions that the diameters of excitation beams are less than or equal to 2 mm and the read-out frequency is larger than 70 kHz, the sensitivity of the atomic receiver is limited only by the quantum noise and, in the other conditions, limited by classical noises. However, the experimental quantum-projection-noise-limited sensitivity this atomic receiver reaches is far from the theoretical sensitivity. This is because all atoms involved in light-atom interaction will contribute to noise, but only a fraction of them participating in the radio wave transition can provide valuable signals. At the same time, the calculation of the theoretical sensitivity considers both the noise and signal are contributed by the same amount of atoms. This work is essential in making the sensitivity of the atomic receiver reach its ultimate limit and is significant in quantum precision measurement

Quantum scaling atomic superheterodyne receiver

Measurement sensitivity is one of the critical indicators for Rydberg atomic radio receivers. This work quantitatively studies the relationship between the atomic superheterodyne receiver's sensitivity and the number of atoms involved in the measurement. The atom number is changed by adjusting the length of the interaction area. The results show that for the ideal case, the sensitivity of the atomic superheterodyne receiver exhibits a quantum scaling: the amplitude of its output signal is proportional to the atom number, and the amplitude of its read-out noise is proportional to the square root of the atom number. Hence, its sensitivity is inversely proportional to the square root of the atom number. This work also gives a detailed discussion of the properties of transit noise in atomic receivers and the influence of some non-ideal factors on sensitivity scaling. This work is significant in the field of atom-based quantum precision measurements

The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.

Prostate cancer at advanced stages including metastatic and castration-resistant cancer remains incurable due to the lack of effective therapies. The CAMK2N1 gene, cloned and characterized as an inhibitor of CaMKII (calcium/calmodulin-dependent protein kinase II), has been shown to affect tumorigenesis and tumor growth. However, it is still unknown whether CAMK2N1 plays a role in prostate cancer development. We first examined the protein and mRNA levels of CAMK2N1 and observed a significant decrease in human prostate cancers comparing to normal prostate tissues. Re-expression of CAMK2N1 in prostate cancer cells reduced cellular proliferation, arrested cells in G0/G1 phases, and induced apoptotic cell death accompanied by down-regulation of IGF-1, ErbB2, and VEGF downstream kinases PI3K/AKT, as well as the MEK/ERK-mediated signaling pathways. Conversely, knockdown of CAMK2N1 had a significant opposite effects on these phenotypes. Our analyses suggest that CAMK2N1 plays a tumor suppressive role in prostate cancer cells. Reduced CAMK2N1 expression correlates to human prostate cancer progression and predicts poor clinical outcome, indicating that CAMK2N1 may serve as a biomarker. The inhibition of tumor growth by expressing CAMK2N1 established a role of CAMK2N1 as a therapeutic target

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.

Castration resistance is a major obstacle to hormonal therapy for prostate cancer patients. Although androgen independence of prostate cancer growth is a known contributing factor to endocrine resistance, the mechanism of androgen receptor deregulation in endocrine resistance is still poorly understood. Herein, the CAMK2N1 was shown to contribute to the human prostate cancer cell growth and survival through AR-dependent signaling. Reduced expression of CAMK2N1 was correlated to recurrence-free survival of prostate cancer patients with high levels of AR expression in their tumor. CAMK2N1 and AR signaling form an auto-regulatory negative feedback loop: CAMK2N1 expression was down-regulated by AR activation; while CAMK2N1 inhibited AR expression and transactivation through CAMKII and AKT pathways. Knockdown of CAMK2N1 in prostate cancer cells alleviated Casodex inhibition of cell growth, while re-expression of CAMK2N1 in castration-resistant cells sensitized the cells to Casodex treatment. Taken together, our findings suggest that CAMK2N1 plays a tumor suppressive role and serves as a crucial determinant of the resistance of prostate cancer to endocrine therapies

Identification and optimization of traffic bottleneck with signal timing

In urban transportation network, traffic congestion is likely to occur at traffic bottlenecks. The signal timing at intersections together with static properties of left-turn and straight-through lanes of roads are two significant factors causing traffic bottlenecks. A discrete-time model of traffic bottleneck is hence developed to analyze these two factors, and a bottleneck indicator is introduced to estimate the comprehensive bottleneck degree of individual road in regional transportation networks universally, the identification approaches are presented to identify traffic bottlenecks, bottleneck-free roads, and bottleneck-prone roads. Based on above work, the optimization method applies ant colony algorithm with effective green time as decision variables to find out an optimal coordinated signal timing plan for a regional network. In addition, a real experimental transportation network is chosen to verify the validation of bottleneck identification. The bottleneck identification approaches can explain the features of occurrence and dissipation of traffic congestion in a certain extent, and the bottleneck optimization method provides a new way to coordinate signal timing at intersections to mitigate traffic congestion

High-internal-phase emulsions (HIPEs) for co-encapsulation of probiotics and curcumin : enhanced survivability and controlled release

Synergistic biological activities of probiotics and curcumin can be achieved based on the gut-brain axis. However, it is still a challenge for utilizing both of them in actual food products due to their high sensitivity to environmental conditions. In the present study, high-internal-phase emulsions (HIPEs) were fabricated to co-encapsulate the probiotics and curcumin in response to the customer demand for convenience. beta-Lactoglobulin-propylene glycol alginate composite hydrogel particles (beta-lgPPs) with proper size and intermediate wettability were prepared at beta-lg to PGA mass ratio of 2 : 1 and employed as particulate emulsifiers. Stable HIPEs with a fixed oil fraction (phi = 0.8) could be formed within a wide range of beta-lgPPs concentrations, ranging from 0.1 to 2.0 wt%. Confocal laser scanning microscopy (CLSM) images indicated that the interfacial structure of the oil droplets was composed of both beta-lg nanoparticles and a PGA network, which jointly contributed to the gel-like structures in HIPEs. An increase in elasticity and gel strength, as well as centrifugal stability, could be achieved by elevating the particle concentration as determined by diffusing wave spectroscopy and Lumisizer analysis. HIPEs with high particle concentrations showed a high resistance against pasteurization since no obvious flocculation or coalescence could be observed in these emulsions. HIPEs also provoked a significant reduction in the death of LGG as well as the chemical degradation of curcumin: up to 7.91 log CFU cm(-3) of LGG and 93.0% of curcumin were retained after pasteurization treatment. Moreover, the HIPEs could also retard the release of curcumin and protect the LGG in simulated gastrointestinal tract conditions. The results from this work provide useful information for developing a promising delivery system for the co-encapsulation of curcumin and probiotics

Plasma miRNA profiles associated with stable warfarin dosage in Chinese patients

Background We used bioinformatic analysis and quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays to investigate the association between plasma microRNAs (miRNAs) and stable warfarin dosage in a Chinese Han population. Methods Bioinformatics analysis was used to screen out potential warfarin dose-associated miRNAs. Three plasma miRNAs were validated in 99 samples by RT-qPCR. Kruskal–Wallis test and multivariate logistic regression were used to compare differences in plasma miRNAs expression levels between three warfarin dosage groups. Results There were significant between-group differences among the three dose groups for hsa-miR-133b expression (p = 0.005), but we observed an “n-shaped” dose-dependent curve rather than a linear relationship. Expression levels of hsa-miR-24-3p (p = 0.475) and hsa-miR-1276 (p = 0.558) were not significantly different in the multivariate logistic regression. Conclusion miRNAs have received extensive attention as ideal biomarkers and possible therapeutic targets for various diseases. However, they are not yet widely used in precision medicine. Our results indicate that hsa-miR-133b may be a possible reference factor for the warfarin dosage algorithm. These findings emphasize the importance of a comprehensive evaluation of complex relationships in warfarin dose prediction models and provide new avenues for future pharmacogenomics studies