1 research outputs found
Achiral Sm(III)-Based Metal–Organic Framework as a Luminescence Sensor for Enantiodiscrimination of Quinine and Quinidine
The effective discrimination and determination of the
chiral antimalarial
drugs quinine (QN) and quinidine (QD) are extremely important for
human health. Herein, a 2D achiral Sm-based metal–organic framework
(IMU-MOF1 = [Sm(tpba)(L)]n, where Htpba = 4-(2,2′:6″,2′-terpyridin)-4′-ylbenzioc
acid and H2L = 2,2′-biquinoline-4,4′-dicarboxylic
acid) was successfully prepared by the solvothermal method. More importantly,
IMU-MOF1 was designed as an ultrasensitive fluorescent
probe for the identification of chiral enantiomer drugs. The limits
of detection for QN and QD are 4.24 × 10–11 and 7.54 × 10–12 M, respectively. Furthermore,
it was demonstrated that the stronger hydrogen-bonding interactions
between IMU-MOF1 and quinine furnish a more efficient
energy transfer to the ligands in the sensing process, resulting in
a significant fluorescence enhancement of IMU-MOF1