41 research outputs found
A unified approach to nonlocal impulsive differential equations with the measure of noncompactness
Solutions to impulsive integrodifferential evolution equations under a noncompact evolution system
Solutions to nonlocal fractional differential equations using a noncompact semigroup
This article concerns the existence of solutions to nonlocal fractional
differential equations in Banach spaces. By using a type of
newly-defined measure of noncompactness, we discuss this problem
in general Banach spaces without any compactness assumptions to
the operator semigroup. Some existence results are obtained when
the nonlocal term is compact and when is Lipschitz continuous
Table_1_Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature.docx
IntroductionSecondary gliosarcomas (SGS) are rare malignancies that are diagnosed subsequent to pre-existing glioma. Clinical features and optimal treatment strategies for SGS have not been conclusively established. This study aimed to assess the clinicopathological features and outcomes of SGS.MethodsWe assessed the clinicopathological features and outcomes of SGS via retrospective analysis of data for SGS patients at Tangdu Hospital. Data from SGS patients in prior publications were also analyzed in accordance with PRISMA guidelines.ResultsEighteen SGS patients who had been treated at Tangdu Hospital between 2013 and 2020 were enrolled in this study. Additional 89 eligible SGS patients were identified from 39 studies. The median age for the patients was 53 years old, and the most common location was the temporal lobe. The most common initial diagnosis was glioblastoma (GBM) (72.0%). Radiology revealed enhanced masses in 94.8% (73/77) of patients. Ten patients (10/107, 9.35%) had extracranial metastases at or after SGS diagnosis. Patients with initial diagnosis of non-GBM and who were younger than 60 years of age were significantly associated with a long duration of disease progression to SGS. After SGS diagnosis, patients with initial non-GBM diagnosis, gross total resection and chemoradiotherapy exhibited prolonged survival outcomes. Patients who had been initially diagnosed with GBM and received both chemoradiotherapy and active therapy after disease progression to SGS, had a significantly longer overall survival than patients who did not.ConclusionInitial diagnosis of GBM was a poor prognostic factor for SGS. Patients who underwent gross total resection and chemoradiation had better overall survival outcomes than those who did not. However, during treatment, clinicians should be cognizant of possible extracranial metastases.</p
Image_1_The role of preoperative inflammatory markers in patients with central nervous system tumors, focus on glioma.tif
BackgroundCNS tumors, particularly gliomas, are associated with a high rate of disability and lethality, and are typically diagnosed with histopathology and immunohistochemistry. Our research aims to develop a minimally invasive method for diagnosing, grading and molecular typing glioma.MethodsWe collected patients who underwent surgery for glioma, Trigeminal neuralgia/Hemifacial spasm, schwannoma, pituitary adenomas and meningioma at our hospital from June 2019 to June 2021. Preoperative WBCs, neutrophils, lymphocytes, monocytes, platelet counts and albumin levels were collected. Preoperative NLR, dNLR, PLR, LMR and PNI were calculated, and the correlation between them and glioma diagnosis as well as grading was analyzed. We also evaluated the diagnostic significance of NLR, dNLR, PLR, LMR, PNI and their combinations for gliomas, particularly GBM, as well as the diagnostic significance of IDH molecular typing of gliomas.ResultsThere were 182 healthy samples and 3101 diseased samples in our study. Compared with other groups, glioma patients had significantly higher preoperative NLR, dNLR and PLR values, but lower LMR and PNI values. Further analysis showed that NLR, dNLR, and PLR were positively correlated with glioma grading, while LMR and PNI were negatively correlated with glioma grading. For the diagnosis of glioma, NLR showed a maximum AUC value of 0.8099 (0.7823-0.8374). For GBM, NLR showed a maximum AUC value of 0.9585 (0.9467-0.9703). In the combination, NLR+dNLR showed the highest AUC value of 0.8070(0.7849-0.8291). NLR showed significant statistical significance in all grades of glioma IDH molecular typing, while PLR did not show statistical significance.ConclusionsNLR has the greatest value for the diagnosis, differential diagnosis, grading and molecular typing of gliomas. The NLR+dNLR combination also showed high sensitivity and specificity. We believe that inflammatory parameters may serve as economical and specific markers for glioma diagnosis, grading, molecular typing, and progression.</p
Image_3_The role of preoperative inflammatory markers in patients with central nervous system tumors, focus on glioma.tif
BackgroundCNS tumors, particularly gliomas, are associated with a high rate of disability and lethality, and are typically diagnosed with histopathology and immunohistochemistry. Our research aims to develop a minimally invasive method for diagnosing, grading and molecular typing glioma.MethodsWe collected patients who underwent surgery for glioma, Trigeminal neuralgia/Hemifacial spasm, schwannoma, pituitary adenomas and meningioma at our hospital from June 2019 to June 2021. Preoperative WBCs, neutrophils, lymphocytes, monocytes, platelet counts and albumin levels were collected. Preoperative NLR, dNLR, PLR, LMR and PNI were calculated, and the correlation between them and glioma diagnosis as well as grading was analyzed. We also evaluated the diagnostic significance of NLR, dNLR, PLR, LMR, PNI and their combinations for gliomas, particularly GBM, as well as the diagnostic significance of IDH molecular typing of gliomas.ResultsThere were 182 healthy samples and 3101 diseased samples in our study. Compared with other groups, glioma patients had significantly higher preoperative NLR, dNLR and PLR values, but lower LMR and PNI values. Further analysis showed that NLR, dNLR, and PLR were positively correlated with glioma grading, while LMR and PNI were negatively correlated with glioma grading. For the diagnosis of glioma, NLR showed a maximum AUC value of 0.8099 (0.7823-0.8374). For GBM, NLR showed a maximum AUC value of 0.9585 (0.9467-0.9703). In the combination, NLR+dNLR showed the highest AUC value of 0.8070(0.7849-0.8291). NLR showed significant statistical significance in all grades of glioma IDH molecular typing, while PLR did not show statistical significance.ConclusionsNLR has the greatest value for the diagnosis, differential diagnosis, grading and molecular typing of gliomas. The NLR+dNLR combination also showed high sensitivity and specificity. We believe that inflammatory parameters may serve as economical and specific markers for glioma diagnosis, grading, molecular typing, and progression.</p
Freestanding Cactus-Like Dual-Phase Bimetallic Metal–Organic Framework as a High-Efficiency Electrocatalyst for Water Oxidation
Realizing
a high-efficiency electrochemical oxygen evolution reaction
(OER) is a great challenge in water splitting and metal–air
battery fields due to the slow reaction kinetics. Herein, a synchronous
dual-phase synthetic strategy is developed to successfully construct
a cactus-like dual-phase bimetallic metal–organic framework
(MOF) on a nickel foam (NF) substrate (noted as NiFe-MOF@NF). It is
constituted by Ni-main NiFe-MOF and Fe-main NiFe-MOF. When functioning
as an anode, the freestanding cactus-like dual-phase NiFe-MOF@NF catalyst
merely requires a lower overpotential of 277 mV to supply 100 mA cm–2 with robust stability (90% retainment of initial
current density after 24 h chronoamperometry measurement). Density
functional theory calculations on the NiFe-MOF@NF catalyst reveal
that the combination of Ni and Fe has efficiently modulated the electron
configuration of metal centers and optimized the absorption/desorption
of OER oxygen-containing intermediates. Thus, we demonstrate a novel
synchronous dual-phase synthetic strategy to engineer freestanding
dual-phase electrocatalysts, which feature multiple synergetic effects
considerably boosting OER performance for optimizing the energy conversion
and storage system
Image_2_The role of preoperative inflammatory markers in patients with central nervous system tumors, focus on glioma.tif
BackgroundCNS tumors, particularly gliomas, are associated with a high rate of disability and lethality, and are typically diagnosed with histopathology and immunohistochemistry. Our research aims to develop a minimally invasive method for diagnosing, grading and molecular typing glioma.MethodsWe collected patients who underwent surgery for glioma, Trigeminal neuralgia/Hemifacial spasm, schwannoma, pituitary adenomas and meningioma at our hospital from June 2019 to June 2021. Preoperative WBCs, neutrophils, lymphocytes, monocytes, platelet counts and albumin levels were collected. Preoperative NLR, dNLR, PLR, LMR and PNI were calculated, and the correlation between them and glioma diagnosis as well as grading was analyzed. We also evaluated the diagnostic significance of NLR, dNLR, PLR, LMR, PNI and their combinations for gliomas, particularly GBM, as well as the diagnostic significance of IDH molecular typing of gliomas.ResultsThere were 182 healthy samples and 3101 diseased samples in our study. Compared with other groups, glioma patients had significantly higher preoperative NLR, dNLR and PLR values, but lower LMR and PNI values. Further analysis showed that NLR, dNLR, and PLR were positively correlated with glioma grading, while LMR and PNI were negatively correlated with glioma grading. For the diagnosis of glioma, NLR showed a maximum AUC value of 0.8099 (0.7823-0.8374). For GBM, NLR showed a maximum AUC value of 0.9585 (0.9467-0.9703). In the combination, NLR+dNLR showed the highest AUC value of 0.8070(0.7849-0.8291). NLR showed significant statistical significance in all grades of glioma IDH molecular typing, while PLR did not show statistical significance.ConclusionsNLR has the greatest value for the diagnosis, differential diagnosis, grading and molecular typing of gliomas. The NLR+dNLR combination also showed high sensitivity and specificity. We believe that inflammatory parameters may serve as economical and specific markers for glioma diagnosis, grading, molecular typing, and progression.</p
Amorphous Metal–Organic Framework-Derived Electrocatalyst to Boost Water Oxidation
Amorphous metal–organic framework
(MOF) materials have drawn
extensive interest in the design of high-performance electrocatalysts
for use in the electrochemical oxygen evolution reaction. However,
there are limitations to the utilization of amorphous MOFs due to
their low electrical conductivity and unsatisfactory stability. Herein,
a novel amorphous–crystalline (AC) heterostructure is successfully
constructed by synthesizing a crystalline metal sulfide (MS)-embedded
amorphous Ni0.67Fe0.33-MOF, namely an MS/Ni0.67Fe0.33-MOF. It exhibits excellent catalytic
performance (a low overpotential of 248 mV at 10 mA cm–2 with a small Tafel slope of 50 mV decade–1), durability,
and stability (only 8% degradation of the current density at a constant
voltage after 24 h). This work thus sheds light on the engineering
of highly efficient catalysts with AC heterointerfaces for optimizing
water-splitting systems